Elias Emeka Elemike , Innocent Chukwujekwu Onunkwo , Odiri Ughumiakpor , Faith Alawuru , Anthony Mukoro , Peter Ishom , Faith Obarakpor , Ismail Hossain , Andrew E. Aziza
{"title":"Bio-nanomaterials: Promising anticancer properties and treatment strategies","authors":"Elias Emeka Elemike , Innocent Chukwujekwu Onunkwo , Odiri Ughumiakpor , Faith Alawuru , Anthony Mukoro , Peter Ishom , Faith Obarakpor , Ismail Hossain , Andrew E. Aziza","doi":"10.1016/j.ntm.2025.100076","DOIUrl":null,"url":null,"abstract":"<div><div>One of the most difficult diseases to treat in people is cancer, and its mortality rate has recently increased significantly. Nanoparticles are used in the rapidly developing field of cancer nanomedicine to diagnose and as well treat cancer. The often-systemic effects with conventional therapy have now been minimized by the ability of nanoparticles to release normally considered insoluble medicines to tumor locations both far and near. Due to their strong qualities and effects, which include biocompatibility, biosafety, biodegradability, synergistic and autologous therapeutic effects, biologically-based nanomaterials have drawn great interests with regards to cancer therapy. It has been extensively discussed and discovered that nucleic acid, polysaccharides, polyphenol or phenolics, proteins (also peptide), cell and subcellular fractions, as well as lipid are bioactive substances. The utilization of these biologically-active materials in nano-formulation is promising toward efficient treatment of cancer through by different oncological therapeutic strategies. As a result of their structural characterizations, adaptable characteristics, anti-tumor processes, and biological performances, these bioactive compounds have been specifically used as examples of the functions of composite nanosystems.</div></div>","PeriodicalId":100941,"journal":{"name":"Nano TransMed","volume":"4 ","pages":"Article 100076"},"PeriodicalIF":0.0000,"publicationDate":"2025-02-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Nano TransMed","FirstCategoryId":"1085","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S279067602500007X","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
引用次数: 0
Abstract
One of the most difficult diseases to treat in people is cancer, and its mortality rate has recently increased significantly. Nanoparticles are used in the rapidly developing field of cancer nanomedicine to diagnose and as well treat cancer. The often-systemic effects with conventional therapy have now been minimized by the ability of nanoparticles to release normally considered insoluble medicines to tumor locations both far and near. Due to their strong qualities and effects, which include biocompatibility, biosafety, biodegradability, synergistic and autologous therapeutic effects, biologically-based nanomaterials have drawn great interests with regards to cancer therapy. It has been extensively discussed and discovered that nucleic acid, polysaccharides, polyphenol or phenolics, proteins (also peptide), cell and subcellular fractions, as well as lipid are bioactive substances. The utilization of these biologically-active materials in nano-formulation is promising toward efficient treatment of cancer through by different oncological therapeutic strategies. As a result of their structural characterizations, adaptable characteristics, anti-tumor processes, and biological performances, these bioactive compounds have been specifically used as examples of the functions of composite nanosystems.