Meng Zhang, Rong Chao, Jia-Jian Wang, Zi-Han Xu, Ji-Hong Zhang, Da-Li Meng, Tai-Zong Wu, Xian-Wen Yang
{"title":"Statins Diversity Revealed by the Deep-Sea-Derived Fungus <i>Penicillium viridicatum</i>.","authors":"Meng Zhang, Rong Chao, Jia-Jian Wang, Zi-Han Xu, Ji-Hong Zhang, Da-Li Meng, Tai-Zong Wu, Xian-Wen Yang","doi":"10.3390/md23020087","DOIUrl":null,"url":null,"abstract":"<p><p>Seven new (<b>1</b>-<b>7</b>) and six known (<b>8</b>-<b>13</b>) statin derivatives were obtained from the deep-sea-derived fungus <i>Penicillium viridicatum</i> MCCC 3A00265. The structures assigned to the new compounds were based on a comprehensive analysis of the spectroscopic data, with absolute configurations established by Mosher analysis and biogenetic consideration. Most of the new compounds (<b>1</b>-<b>5</b> and <b>7</b>) share an octohydronaphthalene backbone, except that viridecalin F (<b>6</b>) possesses an uncommon naphthalene core. Viridecalins C (<b>3</b>) and F (<b>6</b>) and the two known compounds <b>9</b> and <b>11</b> exhibit considerable ability in reactivating mutant p53 protein at 10 μM, while viridecalin C showcases the most potent reactivation activity, indicating the potential of application in cancer therapy.</p>","PeriodicalId":18222,"journal":{"name":"Marine Drugs","volume":"23 2","pages":""},"PeriodicalIF":4.9000,"publicationDate":"2025-02-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11857571/pdf/","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Marine Drugs","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.3390/md23020087","RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"CHEMISTRY, MEDICINAL","Score":null,"Total":0}
引用次数: 0
Abstract
Seven new (1-7) and six known (8-13) statin derivatives were obtained from the deep-sea-derived fungus Penicillium viridicatum MCCC 3A00265. The structures assigned to the new compounds were based on a comprehensive analysis of the spectroscopic data, with absolute configurations established by Mosher analysis and biogenetic consideration. Most of the new compounds (1-5 and 7) share an octohydronaphthalene backbone, except that viridecalin F (6) possesses an uncommon naphthalene core. Viridecalins C (3) and F (6) and the two known compounds 9 and 11 exhibit considerable ability in reactivating mutant p53 protein at 10 μM, while viridecalin C showcases the most potent reactivation activity, indicating the potential of application in cancer therapy.
期刊介绍：
Marine Drugs (ISSN 1660-3397) publishes reviews, regular research papers and short notes on the research, development and production of drugs from the sea. Our aim is to encourage scientists to publish their experimental and theoretical research in as much detail as possible, particularly synthetic procedures and characterization information for bioactive compounds. There is no restriction on the length of the experimental section.
京公网安备 11010802042870号
京ICP备2023020795号-1
分享
求助内容：
应助结果提醒方式：
扫码关注我们
