Gut Microbiota Profile and Functional Gastrointestinal Disorders in Infants: A Longitudinal Study.

IF 5 2区医学 Q1 NUTRITION & DIETETICS Nutrients Pub Date : 2025-02-16 DOI:10.3390/nu17040701

Alexandru Cosmin Pantazi, Cristina Maria Mihai, Ancuta Lupu, Adriana Luminita Balasa, Tatiana Chisnoiu, Larisia Mihai, Corina Elena Frecus, Adina Ungureanu, Sergiu Ioachim Chirila, Wassan Nori, Vasile Valeriu Lupu, Ramona Mihaela Stoicescu, Ginel Baciu, Simona Claudia Cambrea

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Abstract

Background/objectives: The gut microbiota is involved in modulating gastrointestinal function and consequently contributes to the manifestation of functional gastrointestinal disorders (FGIDs). The aim of the study was to analyze the composition of the gut microbiota in infants with functional gastrointestinal disorders (infantile colic, functional constipation, gastroesophageal reflux, functional diarrhea) according to age, environmental factors, and clinical manifestations.

Methods: The study involved the clinical and laboratory examination of 134 infants divided into two groups: group I (n = 82) with FGIDs according to Rome IV criteria, divided into four subgroups (infantile colic, functional constipation, gastroesophageal reflux, and functional diarrhea), and group II (n = 52) without FGIDs. To assess the composition of intestinal microbiota, a bacteriological analysis of fecal samples was performed.

Results: Infants with functional gastrointestinal disorders presented an imbalance of intestinal microflora, which was characterized by a significant decrease in the main representatives of acidifying flora represented by Lactobacillus, Bifidobacterium, and Enterococcus and high abundance of proteolytic microorganisms from the Enterobacteriaceae family such as Klebsiella species and Escherichia coli. In infants born by cesarean section or artificially fed, the incidence of functional gastrointestinal disorders and intestinal dysbiosis was significantly higher.

Conclusions: The imbalance of acidifying and proteolytic microbial composition in the gut could be the key to the occurrence of functional gastrointestinal disorders in the first year of life.

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婴儿肠道微生物群与功能性胃肠疾病：一项纵向研究。

背景/目的：肠道微生物群参与调节胃肠功能，因此有助于功能性胃肠疾病（fgid）的表现。本研究的目的是根据年龄、环境因素和临床表现，分析功能性胃肠疾病（婴儿绞痛、功能性便秘、胃食管反流、功能性腹泻）婴儿肠道菌群的组成。方法：本研究对134例婴儿进行临床和实验室检查，根据Rome IV标准分为两组：ⅰ组（n = 82）有FGIDs，分为4个亚组（婴儿绞痛、功能性便秘、胃食管反流和功能性腹泻），ⅱ组（n = 52）无FGIDs。为了评估肠道微生物群的组成，对粪便样本进行了细菌学分析。结果：功能性胃肠疾病患儿肠道菌群失衡，主要表现为以乳酸杆菌、双歧杆菌、肠球菌为代表的酸化菌群显著减少，克雷伯氏菌、大肠杆菌等肠杆菌科蛋白水解菌高丰度。剖宫产或人工喂养出生的婴儿，功能性胃肠道疾病和肠道生态失调的发生率明显较高。结论：肠道酸化和蛋白水解微生物组成失衡可能是1岁儿童发生功能性胃肠道疾病的关键。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Nutrients NUTRITION & DIETETICS-

CiteScore

9.20

自引率

15.30%

发文量

4599

审稿时长

16.74 days

期刊介绍： Nutrients (ISSN 2072-6643) is an international, peer-reviewed open access advanced forum for studies related to Human Nutrition. It publishes reviews, regular research papers and short communications. Our aim is to encourage scientists to publish their experimental and theoretical results in as much detail as possible. There is no restriction on the length of the papers. The full experimental details must be provided so that the results can be reproduced.