Effect of the aspect ratio and wall heterogeneities on the mechanical behaviour of the aneurysm wall: Experimental investigation on phantom arteries

Abstract

The management of unruptured intracranial aneurysms (UIA) involves assessing the risk of rupture, which requires a thorough understanding of risk factors such as the geometric characteristics of the neck (neck size) or local structural heterogeneities. This study explores the impact of neck size on the rupture risk of the aneurysmal sac and examines how local heterogeneities, such as calcifications or variations in tissue composition, influence the mechanical response of the wall of a saccular aneurysm during the insertion of an innovative arterial wall deformation device (DDP). The results reveal that high aspect ratios (AR) are associated with increased hemodynamic stress, thereby raising the risk of rupture. Additionally, this study provides valuable insights into the complex relationship between tissue heterogeneity, especially calcifications, and the mechanical response of aneurysm walls to mechanical stimuli. It appears that local heterogeneities weaken the integrity of the arterial wall, thus increasing the potential for rupture. Finally, although the DDP is not intended to treat intracranial aneurysms (IA), it could prove to be a relevant tool for deepening the understanding of their rupture mechanisms.