Infrequent Need for Temporary Mechanical Circulatory Support After Mitral Valve Surgery

Tomoki Sakata MD, PhD , Yuki Nakamura MD, PhD , Keshava Rajagopal MD, PhD , Vakhtang Tchantchaleishvili MD , Konstadinos A. Plestis MD , John W. Entwistle III MD, PhD , Joseph E. Bavaria MD , Rakesh M. Suri MD, DPhil
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Abstract

Background

Temporary mechanical circulatory support (tMCS) may be necessary to treat low cardiac output syndrome after mitral valve surgery (MVS) for chronic severe mitral regurgitation (MR). However, prevalence and predictors remain undetermined.

Methods

This single-center retrospective cohort study included 443 patients who underwent primary MVS for degenerative, ischemic, or functional MR between January 2013 and June 2023. Patients requiring tMCS intraoperatively or postoperatively were compared with patients who did not require tMCS. Multivariable logistic regression identified independent risk factors for tMCS requirement.

Results

tMCS was required in 12 of 443 patients (2.7%), with degenerative (2.1%), functional (1.8%), and ischemic (8.3%) MR. Independent risk factors for tMCS requirement were preoperative left ventricular ejection fraction <50% (odds ratio, 4.94; P = .01) and mitral valve replacement (odds ratio, 5.85; P = .005). MR type was not independently influential. The 30-day mortality was 41.7% (5 of 12) in the tMCS group vs 3.5% (15 of 431) in the non-tMCS group (P < .0001).

Conclusions

Requirements for tMCS after MVS for MR are infrequent, but tMCS is associated with high mortality. Low preoperative left ventricular ejection fraction and mitral valve replacement are independent risk factors, thus suggesting that careful surgical planning and meticulous postoperative monitoring are warranted in high-risk cases.
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二尖瓣手术后不常需要临时机械循环支持
背景:对于慢性严重二尖瓣反流(MR)的二尖瓣手术(MVS)后低心输出量综合征,临时机械循环支持(tMCS)可能是必要的。然而,患病率和预测因素仍不确定。这项单中心回顾性队列研究纳入了443例2013年1月至2023年6月期间因退行性、缺血性或功能性MR接受原发性MVS的患者。术中或术后需要tMCS的患者与不需要tMCS的患者进行比较。多变量logistic回归确定了tMCS需求的独立危险因素。结果443例患者中有12例(2.7%)需要进行tMCS,其中退行性mr(2.1%)、功能性mr(1.8%)和缺血性mr(8.3%)需要进行tMCS的独立危险因素为术前左室射血分数<;50%(优势比4.94;P = 0.01)和二尖瓣置换术(优势比5.85;P = .005)。MR类型不具有独立影响。tMCS组30天死亡率为41.7%(5 / 12),非tMCS组为3.5% (15 / 431)(P <;。)。结论磁共振MVS术后需要tMCS的病例并不多见,但tMCS死亡率高。术前左室射血分数低和二尖瓣置换术是独立的危险因素,因此,高危病例需要周密的手术计划和严密的术后监测。
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