Suzuki coupling reaction catalyzed by biosynthesized of gold nanoparticles in water under ultrasonic conditions and its application for treatment of bladder cancer

Abstract

Recently, coupled bio-nanomaterials containing gold nanoparticles have attracted attention as a potentially useful platform for biological composites of the future. Accordingly, we reported a new anticancer agent (Au NPs@GG) supported by Au NPs under sonication energy. Many physicochemical techniques, including UV–Vis spectroscopy, FESEM, TEM, EDX, XRD, and ICP-OES, were used to thoroughly analyze the prepared desired nanocomposite. The material was catalytically explored in the Suzuki-Miyaura coupling for synthesis of different biaryl compounds under aqueous conditions. The catalyst, Au NPs@GG, resulted the related products in good yields at short reaction times. Furthermore, one of the widely utilized antioxidant techniques, DPPH, was employed to study the antioxidant potential of Au NPs@GG. The DPPH test findings demonstrated that Au NPs@GG had superior antioxidant qualities when compared to the controls. The antioxidant test revealed that Au NPs@GG had an IC₅₀ of 135 µg/mL. The Au NPs@GG nanocomposite showed no cytotoxicity on the normal cell line, while its cell viability against bladder cancer (5637 and TCCSUP) cell lines was extremely low. The TCCSUP cell line exhibited the best anti-human bladder cancer characteristics of the nanocomposite when compared to the aforementioned cell lines. The nanocomposite may be used to treat various forms of bladder cancer in people, based on the results given above.