MedicalGLM: A Pediatric Medical Question Answering Model with a quality evaluation mechanism

IF 4 2区 医学 Q2 COMPUTER SCIENCE, INTERDISCIPLINARY APPLICATIONS Journal of Biomedical Informatics Pub Date : 2025-03-07 DOI:10.1016/j.jbi.2025.104793
Xin Wang , Zhaocai Sun , Pingping Wang , Benzheng Wei
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引用次数: 0

Abstract

Objective:

Large Language models (LLMs) have a wide range of medical applications, especially in scenarios such as question-answering. However, existing models face the challenge of accurately assessing the quality of information when generating medical information, which may lead to the inability to effectively distinguish beneficial and harmful information, thus affecting the quality of question-answering. This study aims to improve the information quality and practicability of medical question-answering.

Methods:

This study proposes MedicalGLM, a fine-tuning model based on a quality evaluation mechanism. Specifically, MedicalGLM contains a reward model for assessing the quality of medical QA. It adjusts its training process by returning the assessment scores to the QA model as penalties through a quality score loss function.

Results:

The experimental results indicate that MedicalGLM achieved the highest scores among the evaluated models in the Rouge-1, Rouge-2, Rouge-L, and BLEU metrics, with values of 54.90, 28.02, 44.50, and 32.61, respectively. Its proficiency in generating responses for the pediatric medical quiz task is notably superior to other prevailing LLMs in the medical domain.

Conclusion:

MedicalGLM significantly improves the quality and practicability of the generated information of the medical question-answering model by introducing a quality evaluation mechanism, which provides an effective improvement idea for researching medical large language models. Our code and model are publicly available for further research on https://github.com/wangxinwwang/MedicalGLM.

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来源期刊
Journal of Biomedical Informatics
Journal of Biomedical Informatics 医学-计算机:跨学科应用
CiteScore
8.90
自引率
6.70%
发文量
243
审稿时长
32 days
期刊介绍: The Journal of Biomedical Informatics reflects a commitment to high-quality original research papers, reviews, and commentaries in the area of biomedical informatics methodology. Although we publish articles motivated by applications in the biomedical sciences (for example, clinical medicine, health care, population health, and translational bioinformatics), the journal emphasizes reports of new methodologies and techniques that have general applicability and that form the basis for the evolving science of biomedical informatics. Articles on medical devices; evaluations of implemented systems (including clinical trials of information technologies); or papers that provide insight into a biological process, a specific disease, or treatment options would generally be more suitable for publication in other venues. Papers on applications of signal processing and image analysis are often more suitable for biomedical engineering journals or other informatics journals, although we do publish papers that emphasize the information management and knowledge representation/modeling issues that arise in the storage and use of biological signals and images. System descriptions are welcome if they illustrate and substantiate the underlying methodology that is the principal focus of the report and an effort is made to address the generalizability and/or range of application of that methodology. Note also that, given the international nature of JBI, papers that deal with specific languages other than English, or with country-specific health systems or approaches, are acceptable for JBI only if they offer generalizable lessons that are relevant to the broad JBI readership, regardless of their country, language, culture, or health system.
期刊最新文献
A novel data-driven approach for Personas validation in healthcare using self-supervised machine learning. Tentative renderings: Describing local data infrastructures that support the implementation and evaluation of national evaluation Initiatives. MedicalGLM: A Pediatric Medical Question Answering Model with a quality evaluation mechanism FedIMPUTE: Privacy-preserving missing value imputation for multi-site heterogeneous electronic health records Enhancing generalization of medical image segmentation via game theory-based domain selection
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