Virginia Plá, Erik Kroesbergen, Saiyue Deng, Michael J. Giannetto, Lauren M. Hablitz, Evan Newbold, Antonio Ladrón-de-Guevara, Tina Esmail, Ryszard Stefan Gomolka, Yuki Mori, Steven A. Goldman, Douglas H. Kelley, John H. Thomas, Maiken Nedergaard
{"title":"A curious concept of CNS clearance","authors":"Virginia Plá, Erik Kroesbergen, Saiyue Deng, Michael J. Giannetto, Lauren M. Hablitz, Evan Newbold, Antonio Ladrón-de-Guevara, Tina Esmail, Ryszard Stefan Gomolka, Yuki Mori, Steven A. Goldman, Douglas H. Kelley, John H. Thomas, Maiken Nedergaard","doi":"10.1038/s41593-025-01897-3","DOIUrl":null,"url":null,"abstract":"<p><span>arising from</span> A. Miao et al. <i>Nature Neuroscience</i> https://doi.org/10.1038/s41593-024-01638-y (2024)</p><p>Over the past decade, multiple lines of research have shown that sleep decreases amyloid-β and tau burden compared with wakefulness, and glymphatic clearance is increased during sleep in both human and mouse brains<sup>1,2,3,4,5,6</sup>. A recent study by Miao et al.<sup>7</sup> has questioned these findings. We here raise concerns regarding experimental methodology, analytical rigor, and theoretical and mathematical assumptions in the Miao et al.<sup>7</sup> study. The conclusion of that study—brain clearance is reduced during sleep and anesthesia—is not supported by the data presented.</p>","PeriodicalId":19076,"journal":{"name":"Nature neuroscience","volume":"56 1","pages":""},"PeriodicalIF":21.2000,"publicationDate":"2025-03-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Nature neuroscience","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.1038/s41593-025-01897-3","RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"NEUROSCIENCES","Score":null,"Total":0}
引用次数: 0
Abstract
arising from A. Miao et al. Nature Neuroscience https://doi.org/10.1038/s41593-024-01638-y (2024)
Over the past decade, multiple lines of research have shown that sleep decreases amyloid-β and tau burden compared with wakefulness, and glymphatic clearance is increased during sleep in both human and mouse brains1,2,3,4,5,6. A recent study by Miao et al.7 has questioned these findings. We here raise concerns regarding experimental methodology, analytical rigor, and theoretical and mathematical assumptions in the Miao et al.7 study. The conclusion of that study—brain clearance is reduced during sleep and anesthesia—is not supported by the data presented.
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Nature Neuroscience, a multidisciplinary journal, publishes papers of the utmost quality and significance across all realms of neuroscience. The editors welcome contributions spanning molecular, cellular, systems, and cognitive neuroscience, along with psychophysics, computational modeling, and nervous system disorders. While no area is off-limits, studies offering fundamental insights into nervous system function receive priority.
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In addition to primary research, Nature Neuroscience features news and views, reviews, editorials, commentaries, perspectives, book reviews, and correspondence, aiming to serve as the voice of the global neuroscience community.
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