A complex association with cadmium

IF 14.6 1区 医学 Q1 UROLOGY & NEPHROLOGY Nature Reviews Urology Pub Date : 2025-03-13 DOI:10.1038/s41585-025-01022-w
Annette Fenner
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与镉的复杂联系
镉是一种重金属,经常在水系统和土壤中发现,因为它从工业过程中释放出来。从事生产和使用镍镉电池、磷肥、铜和镍冶炼以及废物焚烧和处置工作的人员存在职业性接触。此外,一般人群可通过吸烟、饮水和食用可积累镉的食物而接触到镉。这种金属的长半衰期意味着它可以在人体组织中积累,导致各种健康问题。膀胱过度活动(OAB)的机制和原因尚不清楚,但镉已知的神经毒性和促炎特性意味着它被认为是一个可能的因素。分析了2007-2020年国家健康与营养检查调查(NHANES)的数据,并使用加权多变量logistic回归评估了血镉水平与OAB及其成分之间的关系。该数据库中15467名应答者中OAB患病率为26.2%。血镉水平与总体OAB相关,但在调整其他变量后,这种关联很小且不显著,尽管OAB组的血镉水平在统计学上高于非OAB组。镉与夜尿症严重程度呈负相关(OR 0.85, 95% CI 0.74-0.98, P <;0.05),并且在50-59岁的成年人和非西班牙裔黑人患者中也与更严重的尿失禁有关。
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来源期刊
Nature Reviews Urology
Nature Reviews Urology 医学-泌尿学与肾脏学
CiteScore
12.50
自引率
2.60%
发文量
123
审稿时长
6-12 weeks
期刊介绍: Nature Reviews Urology is part of the Nature Reviews portfolio of journals.Nature Reviews' basic, translational and clinical content is written by internationally renowned basic and clinical academics and researchers. This journal targeted readers in the biological and medical sciences, from the postgraduate level upwards, aiming to be accessible to professionals in any biological or medical discipline. The journal features authoritative In-depth Reviews providing up-to-date information on topics within a field's history and development. Perspectives, News & Views articles, and the Research Highlights section offer topical discussions and opinions, filtering primary research from various medical journals. Covering a wide range of subjects, including andrology, urologic oncology, and imaging, Nature Reviews provides valuable insights for practitioners, researchers, and academics within urology and related fields.
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