Wen-Xian Li , Lu Gan , Yi-Ling Liao , Yu-Wei Wu , Bai-Hui Zhang , De-an Guo , Wei Li
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引用次数: 0
Abstract
Linaggrenoid A (1), a highly rearranged lindenane sesquiterpenoid, together with eight undescribed lindenane sesquiterpenoid linaggrenoids B–I (2–9) and eight known analogs (10–17), were isolated from the root tubers of Lindera aggregata. Their structures, including absolute configurations, were established using spectroscopic and computational methods, as well as single-crystal X-ray diffraction. Linaggrenoids A and H (1 and 8), featuring a 5/6/3 and 3/5/6 carbocyclic ring system, respectively, demonstrated potential as anti-hepatic fibrosis agents by suppressing the expression of fibronectin, collagen I, and α-smooth muscle actin in TGF-β1-induced LX-2 cells.
期刊介绍：
Phytochemistry is a leading international journal publishing studies of plant chemistry, biochemistry, molecular biology and genetics, structure and bioactivities of phytochemicals, including ''-omics'' and bioinformatics/computational biology approaches. Phytochemistry is a primary source for papers dealing with phytochemicals, especially reports concerning their biosynthesis, regulation, and biological properties both in planta and as bioactive principles. Articles are published online as soon as possible as Articles-in-Press and in 12 volumes per year. Occasional topic-focussed special issues are published composed of papers from invited authors.
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