Arterial Spin Labeling MRI in Alzheimer's Disease: A Systematic Review of Cerebral Perfusion Biomarkers

IF 2.3 4区医学 Q3 CLINICAL NEUROLOGY Journal of Neuroimaging Pub Date : 2025-03-15 DOI:10.1111/jon.70035

Caterina Bernetti, Valerio D'Andrea, Andrea Buoso, Ilenia Barbalace, Federico Greco, Fabio Pilato, Rosalinda Calandrelli, Vincenzo Di Lazzaro, Bruno Beomonte Zobel, Carlo A. Mallio

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Abstract

Background

Alzheimer's disease (AD) is a leading cause of dementia. Arterial spin labeling (ASL) MRI, particularly at 3 Tesla (3T), offers a noninvasive method to assess cerebral blood flow alterations, which are believed to be early indicators of AD.

Purpose

The purpose of this study is to evaluate the utility of 3T ASL MRI in identifying cerebral perfusion biomarkers for the diagnosis and management of AD, assess its prognostic value, and compare it to other imaging modalities, such as PET.

Data Sources

A systematic literature search was conducted following the Preferred Reporting Items for Systematic Reviews and Meta-Analyses guidelines across PubMed, Cochrane Library, and Scopus using keywords related to “ASL,” “3T MRI,” and “AD.”

Study Selection

Studies were included if they used 3T ASL MRI to investigate CBF in AD. Reviews, preclinical studies, case reports, studies lacking 3T ASL MRI, or those focusing on other dementias or mild cognitive impairment without an AD comparison were excluded. Data extracted included study design, sample characteristics, imaging techniques, parameters measured, and outcomes. A qualitative synthesis of findings highlights CBF patterns and biomarkers associated with AD.

Results

Findings demonstrated hypoperfusion in the hippocampus, precuneus, and posterior cingulate cortex, distinguishing AD from normal aging and other forms of dementia. CBF patterns are often correlated with the severity and progression of cognitive impairment. ASL MRI at 3T demonstrated diagnostic accuracy comparable to that of PET while being noninvasive and radiation free.

Conclusion

ASL MRI at 3T could be a valuable tool for the early diagnosis and monitoring of AD. Its noninvasive nature makes it ideal for repeated measures and longitudinal studies. Further research should focus on standardizing protocols and validating their use in larger populations.

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来源期刊

Journal of Neuroimaging 医学-核医学

CiteScore

4.70

自引率

0.00%

发文量

117

审稿时长

6-12 weeks

期刊介绍： Start reading the Journal of Neuroimaging to learn the latest neurological imaging techniques. The peer-reviewed research is written in a practical clinical context, giving you the information you need on: MRI CT Carotid Ultrasound and TCD SPECT PET Endovascular Surgical Neuroradiology Functional MRI Xenon CT and other new and upcoming neuroscientific modalities.The Journal of Neuroimaging addresses the full spectrum of human nervous system disease, including stroke, neoplasia, degenerating and demyelinating disease, epilepsy, tumors, lesions, infectious disease, cerebral vascular arterial diseases, toxic-metabolic disease, psychoses, dementias, heredo-familial disease, and trauma.Offering original research, review articles, case reports, neuroimaging CPCs, and evaluations of instruments and technology relevant to the nervous system, the Journal of Neuroimaging focuses on useful clinical developments and applications, tested techniques and interpretations, patient care, diagnostics, and therapeutics. Start reading today!