Arterial Spin Labeling MRI in Alzheimer's Disease: A Systematic Review of Cerebral Perfusion Biomarkers

IF 2.3 4区 医学 Q3 CLINICAL NEUROLOGY Journal of Neuroimaging Pub Date : 2025-03-15 DOI:10.1111/jon.70035
Caterina Bernetti, Valerio D'Andrea, Andrea Buoso, Ilenia Barbalace, Federico Greco, Fabio Pilato, Rosalinda Calandrelli, Vincenzo Di Lazzaro, Bruno Beomonte Zobel, Carlo A. Mallio
{"title":"Arterial Spin Labeling MRI in Alzheimer's Disease: A Systematic Review of Cerebral Perfusion Biomarkers","authors":"Caterina Bernetti,&nbsp;Valerio D'Andrea,&nbsp;Andrea Buoso,&nbsp;Ilenia Barbalace,&nbsp;Federico Greco,&nbsp;Fabio Pilato,&nbsp;Rosalinda Calandrelli,&nbsp;Vincenzo Di Lazzaro,&nbsp;Bruno Beomonte Zobel,&nbsp;Carlo A. Mallio","doi":"10.1111/jon.70035","DOIUrl":null,"url":null,"abstract":"<div>\n \n \n <section>\n \n <h3> Background</h3>\n \n <p>Alzheimer's disease (AD) is a leading cause of dementia. Arterial spin labeling (ASL) MRI, particularly at 3 Tesla (3T), offers a noninvasive method to assess cerebral blood flow alterations, which are believed to be early indicators of AD.</p>\n </section>\n \n <section>\n \n <h3> Purpose</h3>\n \n <p>The purpose of this study is to evaluate the utility of 3T ASL MRI in identifying cerebral perfusion biomarkers for the diagnosis and management of AD, assess its prognostic value, and compare it to other imaging modalities, such as PET.</p>\n </section>\n \n <section>\n \n <h3> Data Sources</h3>\n \n <p>A systematic literature search was conducted following the Preferred Reporting Items for Systematic Reviews and Meta-Analyses guidelines across PubMed, Cochrane Library, and Scopus using keywords related to “ASL,” “3T MRI,” and “AD.”</p>\n </section>\n \n <section>\n \n <h3> Study Selection</h3>\n \n <p>Studies were included if they used 3T ASL MRI to investigate CBF in AD. Reviews, preclinical studies, case reports, studies lacking 3T ASL MRI, or those focusing on other dementias or mild cognitive impairment without an AD comparison were excluded. Data extracted included study design, sample characteristics, imaging techniques, parameters measured, and outcomes. A qualitative synthesis of findings highlights CBF patterns and biomarkers associated with AD.</p>\n </section>\n \n <section>\n \n <h3> Results</h3>\n \n <p>Findings demonstrated hypoperfusion in the hippocampus, precuneus, and posterior cingulate cortex, distinguishing AD from normal aging and other forms of dementia. CBF patterns are often correlated with the severity and progression of cognitive impairment. ASL MRI at 3T demonstrated diagnostic accuracy comparable to that of PET while being noninvasive and radiation free.</p>\n </section>\n \n <section>\n \n <h3> Conclusion</h3>\n \n <p>ASL MRI at 3T could be a valuable tool for the early diagnosis and monitoring of AD. Its noninvasive nature makes it ideal for repeated measures and longitudinal studies. Further research should focus on standardizing protocols and validating their use in larger populations.</p>\n </section>\n </div>","PeriodicalId":16399,"journal":{"name":"Journal of Neuroimaging","volume":"35 2","pages":""},"PeriodicalIF":2.3000,"publicationDate":"2025-03-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/jon.70035","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Journal of Neuroimaging","FirstCategoryId":"3","ListUrlMain":"https://onlinelibrary.wiley.com/doi/10.1111/jon.70035","RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q3","JCRName":"CLINICAL NEUROLOGY","Score":null,"Total":0}
引用次数: 0

Abstract

Background

Alzheimer's disease (AD) is a leading cause of dementia. Arterial spin labeling (ASL) MRI, particularly at 3 Tesla (3T), offers a noninvasive method to assess cerebral blood flow alterations, which are believed to be early indicators of AD.

Purpose

The purpose of this study is to evaluate the utility of 3T ASL MRI in identifying cerebral perfusion biomarkers for the diagnosis and management of AD, assess its prognostic value, and compare it to other imaging modalities, such as PET.

Data Sources

A systematic literature search was conducted following the Preferred Reporting Items for Systematic Reviews and Meta-Analyses guidelines across PubMed, Cochrane Library, and Scopus using keywords related to “ASL,” “3T MRI,” and “AD.”

Study Selection

Studies were included if they used 3T ASL MRI to investigate CBF in AD. Reviews, preclinical studies, case reports, studies lacking 3T ASL MRI, or those focusing on other dementias or mild cognitive impairment without an AD comparison were excluded. Data extracted included study design, sample characteristics, imaging techniques, parameters measured, and outcomes. A qualitative synthesis of findings highlights CBF patterns and biomarkers associated with AD.

Results

Findings demonstrated hypoperfusion in the hippocampus, precuneus, and posterior cingulate cortex, distinguishing AD from normal aging and other forms of dementia. CBF patterns are often correlated with the severity and progression of cognitive impairment. ASL MRI at 3T demonstrated diagnostic accuracy comparable to that of PET while being noninvasive and radiation free.

Conclusion

ASL MRI at 3T could be a valuable tool for the early diagnosis and monitoring of AD. Its noninvasive nature makes it ideal for repeated measures and longitudinal studies. Further research should focus on standardizing protocols and validating their use in larger populations.

Abstract Image

查看原文
分享 分享
微信好友 朋友圈 QQ好友 复制链接
本刊更多论文
求助全文
约1分钟内获得全文 去求助
来源期刊
Journal of Neuroimaging
Journal of Neuroimaging 医学-核医学
CiteScore
4.70
自引率
0.00%
发文量
117
审稿时长
6-12 weeks
期刊介绍: Start reading the Journal of Neuroimaging to learn the latest neurological imaging techniques. The peer-reviewed research is written in a practical clinical context, giving you the information you need on: MRI CT Carotid Ultrasound and TCD SPECT PET Endovascular Surgical Neuroradiology Functional MRI Xenon CT and other new and upcoming neuroscientific modalities.The Journal of Neuroimaging addresses the full spectrum of human nervous system disease, including stroke, neoplasia, degenerating and demyelinating disease, epilepsy, tumors, lesions, infectious disease, cerebral vascular arterial diseases, toxic-metabolic disease, psychoses, dementias, heredo-familial disease, and trauma.Offering original research, review articles, case reports, neuroimaging CPCs, and evaluations of instruments and technology relevant to the nervous system, the Journal of Neuroimaging focuses on useful clinical developments and applications, tested techniques and interpretations, patient care, diagnostics, and therapeutics. Start reading today!
期刊最新文献
Arterial Spin Labeling MRI in Alzheimer's Disease: A Systematic Review of Cerebral Perfusion Biomarkers Annual Meeting of the American Society of Neuroimaging Issue Information Safety of Indocyanine Green Microdosing for Clinical Imaging of CSF Ventricular Dynamics and Extracranial Outflow Resting-State fMRI to Map Language Function for Surgical Planning in Patients With Brain Tumors: A Feasibility Study
×
引用
GB/T 7714-2015
复制
MLA
复制
APA
复制
导出至
BibTeX EndNote RefMan NoteFirst NoteExpress
×
×
提示
您的信息不完整,为了账户安全,请先补充。
现在去补充
×
提示
您因"违规操作"
具体请查看互助需知
我知道了
×
提示
现在去查看 取消
×
提示
确定
0
微信
客服QQ
Book学术公众号 扫码关注我们
反馈
×
意见反馈
请填写您的意见或建议
请填写您的手机或邮箱
已复制链接
已复制链接
快去分享给好友吧!
我知道了
×
扫码分享
扫码分享
Book学术官方微信
Book学术文献互助
Book学术文献互助群
群 号:481959085
Book学术
文献互助 智能选刊 最新文献 互助须知 联系我们:info@booksci.cn
Book学术提供免费学术资源搜索服务,方便国内外学者检索中英文文献。致力于提供最便捷和优质的服务体验。
Copyright © 2023 Book学术 All rights reserved.
ghs 京公网安备 11010802042870号 京ICP备2023020795号-1