{"title":"Antimicrobial and adhesive dendritic polymer coatings with real-time in situ monitoring via aggregation-induced emission","authors":"Hui Chen, Zihan Li, Qianqian Yu, Weichang Li, Lisha Gu","doi":"10.1007/s42114-025-01271-8","DOIUrl":null,"url":null,"abstract":"<div><p>Denture stomatitis (DS) is a significant health concern among denture wearers, caused by the overgrowth of <i>Candida albicans</i> and leading to inflammation beneath maxillary dentures. Current treatment options, including antifungal medications and denture disinfectants, are often limited by adverse effects and reduced efficacy. To address these challenges, this study aims to develop a novel dendritic polymer coating for dentures, which incorporates hydrophobic quaternary ammonium salts (QAS), hydrophilic catechol functional groups, and aggregation-induced emission (AIE) fluorophores. QAS, known for their broad-spectrum antimicrobial activity, are integrated into the coating to enhance the adhesion and antimicrobial properties. Catechol functional groups, rich in the dendritic polymer structure, contribute to improved stability and adhesion of the coating, which is crucial for long-term efficacy in the dynamic oral environment. Additionally, AIE fluorophores enable real-time monitoring of coating integrity, overcoming limitations of traditional fluorescent dyes. The study focuses on optimizing coating construction techniques, with an emphasis on enhancing adhesion, antimicrobial functionality, and real-time monitoring capabilities. Investigations into the antimicrobial mechanism of the coating aim to elucidate its potential in combating DS and offering solutions for therapeutic dentures. This approach presents a promising alternative to current treatments, addressing the urgent need for effective and durable antifungal therapies for denture-related stomatitis.</p><h3>Graphical abstract</h3>\n<div><figure><div><div><picture><source><img></source></picture></div></div></figure></div></div>","PeriodicalId":7220,"journal":{"name":"Advanced Composites and Hybrid Materials","volume":"8 2","pages":""},"PeriodicalIF":23.2000,"publicationDate":"2025-03-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://link.springer.com/content/pdf/10.1007/s42114-025-01271-8.pdf","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Advanced Composites and Hybrid Materials","FirstCategoryId":"88","ListUrlMain":"https://link.springer.com/article/10.1007/s42114-025-01271-8","RegionNum":2,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"MATERIALS SCIENCE, COMPOSITES","Score":null,"Total":0}
引用次数: 0
Abstract
Denture stomatitis (DS) is a significant health concern among denture wearers, caused by the overgrowth of Candida albicans and leading to inflammation beneath maxillary dentures. Current treatment options, including antifungal medications and denture disinfectants, are often limited by adverse effects and reduced efficacy. To address these challenges, this study aims to develop a novel dendritic polymer coating for dentures, which incorporates hydrophobic quaternary ammonium salts (QAS), hydrophilic catechol functional groups, and aggregation-induced emission (AIE) fluorophores. QAS, known for their broad-spectrum antimicrobial activity, are integrated into the coating to enhance the adhesion and antimicrobial properties. Catechol functional groups, rich in the dendritic polymer structure, contribute to improved stability and adhesion of the coating, which is crucial for long-term efficacy in the dynamic oral environment. Additionally, AIE fluorophores enable real-time monitoring of coating integrity, overcoming limitations of traditional fluorescent dyes. The study focuses on optimizing coating construction techniques, with an emphasis on enhancing adhesion, antimicrobial functionality, and real-time monitoring capabilities. Investigations into the antimicrobial mechanism of the coating aim to elucidate its potential in combating DS and offering solutions for therapeutic dentures. This approach presents a promising alternative to current treatments, addressing the urgent need for effective and durable antifungal therapies for denture-related stomatitis.
期刊介绍：
Advanced Composites and Hybrid Materials is a leading international journal that promotes interdisciplinary collaboration among materials scientists, engineers, chemists, biologists, and physicists working on composites, including nanocomposites. Our aim is to facilitate rapid scientific communication in this field.
The journal publishes high-quality research on various aspects of composite materials, including materials design, surface and interface science/engineering, manufacturing, structure control, property design, device fabrication, and other applications. We also welcome simulation and modeling studies that are relevant to composites. Additionally, papers focusing on the relationship between fillers and the matrix are of particular interest.
Our scope includes polymer, metal, and ceramic matrices, with a special emphasis on reviews and meta-analyses related to materials selection. We cover a wide range of topics, including transport properties, strategies for controlling interfaces and composition distribution, bottom-up assembly of nanocomposites, highly porous and high-density composites, electronic structure design, materials synergisms, and thermoelectric materials.
Advanced Composites and Hybrid Materials follows a rigorous single-blind peer-review process to ensure the quality and integrity of the published work.
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