DNA-collagen dressing for promoting scarless healing in early burn wound management

IF 23.2 2区材料科学 Q1 MATERIALS SCIENCE, COMPOSITES Advanced Composites and Hybrid Materials Pub Date : 2025-03-19 DOI:10.1007/s42114-025-01295-0

Jing-han Song, Jun-ting Gu, Gao-peng Dang, Mei-chen Wan, Yong-kang Bai, Que Bai, Kai Jiao, Li-na Niu

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Abstract

In the early stages of healing severe burn wounds, increased exudate and immune dysregulation heighten the risk of scar formation. Current dressings for severe burns present significant challenges and are inadequate in effectively managing early burn wounds. To address the above challenges, a deoxyribonucleic acid-functionalized collagen dressing with aligned channels and interconnected porous structure (DNA-Cryo-ACol) was developed. The DNA-Cryo-ACol dressing demonstrated superior exudate drainage abilities: (i) draining excess exudate at a rate 50 times faster than commercial dressings; (ii) doubling the maximum exudate absorption capacity compared to commercial dressings; and (iii) preventing exudate maceration through evident capillary action. Furthermore, DNA-Cryo-ACol dressings exhibited the immunomodulatory property to regulate immune responses mediated by CD4 + T cells. Results indicated that the interaction between DNA-Cryo-ACol dressing and CD4 + T cells stimulated the production of scar-inhibiting cytokines while reducing the expression of α-smooth muscle actin. By effectively managing exudate drainage and immune response, DNA-Cryo-ACol dressings significantly promoted tissue regeneration in healed burn wounds, resulting in a sevenfold increase in hair regrowth and recovery of collagen components to levels comparable to unwounded skin. The findings from this study laid the groundwork for the development of smart materials aimed at early burn wound management to inhibit scarring.

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来源期刊

Advanced Composites and Hybrid Materials Multiple-

CiteScore

26.00

自引率

21.40%

发文量

185

期刊介绍： Advanced Composites and Hybrid Materials is a leading international journal that promotes interdisciplinary collaboration among materials scientists, engineers, chemists, biologists, and physicists working on composites, including nanocomposites. Our aim is to facilitate rapid scientific communication in this field. The journal publishes high-quality research on various aspects of composite materials, including materials design, surface and interface science/engineering, manufacturing, structure control, property design, device fabrication, and other applications. We also welcome simulation and modeling studies that are relevant to composites. Additionally, papers focusing on the relationship between fillers and the matrix are of particular interest. Our scope includes polymer, metal, and ceramic matrices, with a special emphasis on reviews and meta-analyses related to materials selection. We cover a wide range of topics, including transport properties, strategies for controlling interfaces and composition distribution, bottom-up assembly of nanocomposites, highly porous and high-density composites, electronic structure design, materials synergisms, and thermoelectric materials. Advanced Composites and Hybrid Materials follows a rigorous single-blind peer-review process to ensure the quality and integrity of the published work.