Two-Sample Mendelian Randomization Analyses Identified Lipid Species Associated With Intracranial Aneurysm Formation

IF 2.6 3区心理学 Q2 BEHAVIORAL SCIENCES Brain and Behavior Pub Date : 2025-03-18 DOI:10.1002/brb3.70435

Junqing Yan

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Abstract

Objectives

Intracranial aneurysm (IA) poses a significant health risk, and its formation involves various factors, including lipid metabolism, while former research only focused on the standard lipid. The purpose of this study is to explore 179 lipid variants' impact on unruptured intracranial aneurysms (uIA).

Materials and Methods

Utilizing GWAS data for lipids and uIAs, MR analyses were employed with pleiotropy, heterogeneity, and sensitivity tests. Reverse MR analyses were then conducted.

Results

MR analyses revealed seven lipids associated with uIAs: TAG (51:3). SE (27:1/16:1), PC (18:2_18:2), TAG (48:1), TAG (48:2), and TAG (51:3) were identified as uIA risk factors, while SE (27:1/18:1) and SM (d34:0) exhibited protective effects. Reverse MR analysis showed no bidirectional causal relationships.

Conclusions

This study identifies specific lipid variants causally linked to uIAs, shedding light on their roles in IA formation. These findings contribute to future research on IA risk assessment and potential therapeutic interventions.

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来源期刊

Brain and Behavior BEHAVIORAL SCIENCES-NEUROSCIENCES

CiteScore

5.30

自引率

0.00%

发文量

352

审稿时长

14 weeks

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