The Relationship Between Grip Strength and Cognitive Impairment: Evidence From NHANES 2011–2014

IF 2.7 3区心理学 Q2 BEHAVIORAL SCIENCES Brain and Behavior Pub Date : 2025-03-18 DOI:10.1002/brb3.70381

Wenyi Nie, Jingqing Hu

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Abstract

Background

Prior research has consistently shown an association between muscle strength and various metabolic diseases. However, the relationship between muscle strength and cognitive impairment remains elusive.

Methods

Using data from the 2011–2014 National Health and Nutrition Examination Survey (NHANES), we investigated the association between muscle strength and cognitive impairment. We used multivariate logistic regression, restricted cubic spline regression (RCS), and threshold effects to investigate the impact of muscle strength on cognitive function. In addition, we analyzed the correlation between muscle strength and cognitive impairment in subgroups of age, gender, race, education, smoking status, drinking status, hypertension, diabetes, and heart disease.

Results

2124 participants were ultimately included for further analysis. Multivariate logistic regression, trend testing, and RCS analysis showed a non-linear negative correlation between muscle strength and cognitive impairment. Threshold effect analysis suggests that when muscle strength reaches a certain value, this relationship undergoes significant changes. In the three cognitive function scoring tests, interaction was only observed in the racial subgroup.

Conclusion

This study suggests a negative correlation between muscle strength and cognitive function, which may have a threshold effect. Further longitudinal studies are needed to elucidate its potential mechanisms.

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握力与认知障碍的关系：来自NHANES 2011-2014的证据

先前的研究一致表明肌肉力量与各种代谢疾病之间存在关联。然而，肌肉力量和认知障碍之间的关系仍然难以捉摸。方法利用2011-2014年全国健康与营养调查（NHANES）的数据，研究肌肉力量与认知功能障碍之间的关系。我们使用多元逻辑回归、受限三次样条回归（RCS）和阈值效应来研究肌肉力量对认知功能的影响。此外，我们还分析了年龄、性别、种族、教育程度、吸烟状况、饮酒状况、高血压、糖尿病和心脏病等亚组中肌肉力量与认知功能障碍之间的相关性。结果最终纳入2124名受试者进行进一步分析。多因素logistic回归、趋势检验和RCS分析显示肌力与认知功能障碍呈非线性负相关。阈值效应分析表明，当肌力达到一定值时，这种关系发生显著变化。在三项认知功能评分测试中，仅在种族亚组中观察到相互作用。结论肌肉力量与认知功能呈负相关，可能存在阈值效应。需要进一步的纵向研究来阐明其潜在的机制。

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来源期刊

Brain and Behavior BEHAVIORAL SCIENCES-NEUROSCIENCES

CiteScore

5.30

自引率

0.00%

发文量

352

审稿时长

14 weeks

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