Assessing Etoposide and Cyclophosphamide Contamination and Current Cleaning Practices in Patient Bathrooms.

IF 1.2 4区 医学 Q3 NURSING Clinical journal of oncology nursing Pub Date : 2025-03-14 DOI:10.1188/25.CJON.E52-E59
AnnMarie L Walton, Margaret A Bush, Anthony D Sung, Melissa A Powell, Haesu J Jin, Susan G Silva, Ivan Spasojevic
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Abstract

Background: Antineoplastic drug (AD) exposure presents severe risks to healthcare workers. Previous studies have demonstrated that patient bathrooms are highly contaminated and have led to concern for excreta as a source of environmental contamination with ADs.

Objectives: This study assessed AD contamination and current cleaning practices to remove AD surface contamination in patient bathrooms.

Methods: Three surfaces in the bathrooms of patients who had received etoposide and/or cyclophosphamide were sampled and analyzed for contamination at three time points. Liquid chromatography-tandem mass spectrometry was used for analysis. Interviews and observations of daily and discharge cleaning were conducted to understand cleaning practices.

Findings: A significant reduction in etoposide contamination on toilets and floors was observed following discharge cleaning; however, no significant reduction was observed on walls for either AD or on floors for cyclophosphamide.

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评估患者浴室中依托泊苷和环磷酰胺污染和当前清洁措施。
背景:抗肿瘤药物(AD)暴露给医护人员带来了严重的风险。先前的研究表明,病人的浴室是高度污染的,并且引起了人们对排泄物作为AD环境污染来源的关注。目的:本研究评估了AD污染和目前清除患者浴室AD表面污染的清洁方法。方法:对接受依托泊苷和/或环磷酰胺治疗的患者的浴室三个表面取样,分析三个时间点的污染情况。采用液相色谱-串联质谱法进行分析。对日常清洁和出院清洁进行访谈和观察,以了解清洁做法。研究结果:排泄物清洁后,厕所和地板上的依托泊苷污染显著减少;然而,无论是墙壁上的AD还是地板上的环磷酰胺,都没有观察到明显的减少。
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来源期刊
CiteScore
1.70
自引率
9.10%
发文量
127
审稿时长
6-12 weeks
期刊介绍: The Clinical Journal of Oncology Nursing (CJON) is an official publication of the Oncology Nursing Society (ONS) and is directed to the practicing nurse specializing in the care of patients with an actual or potential diagnosis of cancer. CJON is a vehicle to promote the mission of ONS, which is to advance excellence in oncology nursing and quality cancer care. The CJON mission is twofold: to provide practical information necessary to care for patients and their families across the cancer continuum and to develop publication skills in oncology nurses.
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