Advancing fungal biodegradation of nonsteroidal anti-inflammatory drugs — challenges and future perspectives

IF 7.1 2区工程技术 Q1 BIOCHEMICAL RESEARCH METHODS Current opinion in biotechnology Pub Date : 2025-03-19 DOI:10.1016/j.copbio.2025.103293

Ninfa Ramírez-Durán , Tonatiuh Moreno-Perlín , Lorna C Can-Ubando , Gauddy L Manzanares-Leal , Pablo A Moreno-Pérez , Horacio Sandoval-Trujillo , Keila Isaac-Olivé , Elisabet Aranda , Ramón Alberto Batista-García

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Abstract

Environmental pollution poses serious threats to ecosystems, human health, and overall quality of life. Among the most concerning pollutants are emerging contaminants like nonsteroidal anti-inflammatory drugs (NSAIDs), commonly used in human and veterinary medicine. These drugs and their metabolites are excreted into wastewater systems, where existing treatment methods often fail to eliminate them fully. Due to their persistence in aquatic environments, NSAIDs accumulate, necessitating innovative degradation strategies. Fungal biotransformation offers a promising solution, using the unique metabolic capabilities of unicellular yeasts and filamentous fungi. This review explores the potential of fungi to degrade NSAIDs through various enzymatic and nonenzymatic pathways. It also highlights key challenges and perspectives in the field, such as understanding NSAID–fungal cell wall interactions, the role of transcriptional factors, and the regulatory networks involved in pharmaceutical biodegradation. The goal is to advance fungal-based strategies for more effective NSAID removal from wastewater, contributing to broader environmental remediation efforts.

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来源期刊

Current opinion in biotechnology 工程技术-生化研究方法

CiteScore

16.20

自引率

2.60%

发文量

226

审稿时长

4-8 weeks

期刊介绍： Current Opinion in Biotechnology (COBIOT) is renowned for publishing authoritative, comprehensive, and systematic reviews. By offering clear and readable syntheses of current advances in biotechnology, COBIOT assists specialists in staying updated on the latest developments in the field. Expert authors annotate the most noteworthy papers from the vast array of information available today, providing readers with valuable insights and saving them time. As part of the Current Opinion and Research (CO+RE) suite of journals, COBIOT is accompanied by the open-access primary research journal, Current Research in Biotechnology (CRBIOT). Leveraging the editorial excellence, high impact, and global reach of the Current Opinion legacy, CO+RE journals ensure they are widely read resources integral to scientists' workflows. COBIOT is organized into themed sections, each reviewed once a year. These themes cover various areas of biotechnology, including analytical biotechnology, plant biotechnology, food biotechnology, energy biotechnology, environmental biotechnology, systems biology, nanobiotechnology, tissue, cell, and pathway engineering, chemical biotechnology, and pharmaceutical biotechnology.