Window of sustainable bioprocess operation: towards merging environmental sustainability assessment and process operation at early-stage bioprocess development

IF 7 2区工程技术 Q1 BIOCHEMICAL RESEARCH METHODS Current opinion in biotechnology Pub Date : 2025-06-01 Epub Date: 2025-03-18 DOI:10.1016/j.copbio.2025.103292

Philipp Demling , Katrin Rosenthal , Alexander Grünberger

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Abstract

Developing and optimizing sustainable bioprocesses require integrating technical feasibility and environmental sustainability assessment at an early stage of process development. Therefore, environmental impact estimations need to be performed alongside the development of novel bioprocesses, and ‘feasibility’ windows need to be defined, in which a bioprocess can be operated robustly and economically while being as environmentally friendly as possible. In this opinion, we summarize the progress made in the field of environmental sustainability assessment and its integration into bioprocesses at an early stage. We propose the ‘window of sustainable bioprocess operation’ (SBO window) as a concept to find operating conditions that match economic and environmental constraints. The insights obtained by the SBO window enable the back-translation of environmental constraints into bioprocess design optimizations and thus lay the foundation for a successful implementation of sustainable bioprocesses in the future.

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可持续生物工艺运行窗口：在生物工艺开发的早期阶段，将环境可持续性评价与工艺运行相结合

开发和优化可持续的生物工艺需要在工艺开发的早期阶段综合技术可行性和环境可持续性评估。因此，环境影响评估需要与新型生物工艺的开发一起进行，并且需要定义“可行性”窗口，在这个窗口中，生物工艺可以在尽可能环保的情况下稳健、经济地运行。在此，我们总结了环境可持续性评价及其早期融入生物过程领域的进展。我们提出了“可持续生物过程操作窗口”（SBO窗口）的概念，以寻找符合经济和环境约束的操作条件。SBO窗口获得的见解能够将环境约束反向转化为生物工艺设计优化，从而为未来成功实施可持续生物工艺奠定基础。

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来源期刊

Current opinion in biotechnology 工程技术-生化研究方法

CiteScore

16.20

自引率

2.60%

发文量

226

审稿时长

4-8 weeks

期刊介绍： Current Opinion in Biotechnology (COBIOT) is renowned for publishing authoritative, comprehensive, and systematic reviews. By offering clear and readable syntheses of current advances in biotechnology, COBIOT assists specialists in staying updated on the latest developments in the field. Expert authors annotate the most noteworthy papers from the vast array of information available today, providing readers with valuable insights and saving them time. As part of the Current Opinion and Research (CO+RE) suite of journals, COBIOT is accompanied by the open-access primary research journal, Current Research in Biotechnology (CRBIOT). Leveraging the editorial excellence, high impact, and global reach of the Current Opinion legacy, CO+RE journals ensure they are widely read resources integral to scientists' workflows. COBIOT is organized into themed sections, each reviewed once a year. These themes cover various areas of biotechnology, including analytical biotechnology, plant biotechnology, food biotechnology, energy biotechnology, environmental biotechnology, systems biology, nanobiotechnology, tissue, cell, and pathway engineering, chemical biotechnology, and pharmaceutical biotechnology.