Freddy Caldera, Mary S Hayney, Francis A Farraye, Monika Fischer, Huiping Xu, Michael D Kappelman
{"title":"Low Incidence of Varicella in Pediatric Patients With Inflammatory Bowel Disease.","authors":"Freddy Caldera, Mary S Hayney, Francis A Farraye, Monika Fischer, Huiping Xu, Michael D Kappelman","doi":"10.14309/ajg.0000000000003418","DOIUrl":null,"url":null,"abstract":"<p><strong>Introduction: </strong>Immune-modifying therapies in pediatric inflammatory bowel disease (IBD) increase infection risks, including varicella.</p><p><strong>Methods: </strong>Using Optum's deidentified Clinformatics Data Mart Database, a nationwide US commercial insurance claims database (2007-2022), we conducted a retrospective study of 5,368 patients with IBD aged 21 years or younger matched to a non-IBD cohort. The primary outcome was incidence of varicella.</p><p><strong>Results: </strong>Varicella incidence was low in both groups (IBD: 0.570 vs non-IBD: 0.297 per 1,000 person-years, P = 0.23). At year 4, cumulative varicella incidence was 0.27% for IBD and 0.18% for non-IBD ( P = 0.24). No hospitalizations or deaths occurred.</p><p><strong>Discussion: </strong>Despite immune-modifying therapy, pediatric patients with IBD demonstrate low varicella incidence.</p>","PeriodicalId":7608,"journal":{"name":"American Journal of Gastroenterology","volume":" ","pages":"2194-2197"},"PeriodicalIF":8.5000,"publicationDate":"2025-03-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"American Journal of Gastroenterology","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.14309/ajg.0000000000003418","RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"GASTROENTEROLOGY & HEPATOLOGY","Score":null,"Total":0}
引用次数: 0
Abstract
Introduction: Immune-modifying therapies in pediatric inflammatory bowel disease (IBD) increase infection risks, including varicella.
Methods: Using Optum's deidentified Clinformatics Data Mart Database, a nationwide US commercial insurance claims database (2007-2022), we conducted a retrospective study of 5,368 patients with IBD aged 21 years or younger matched to a non-IBD cohort. The primary outcome was incidence of varicella.
Results: Varicella incidence was low in both groups (IBD: 0.570 vs non-IBD: 0.297 per 1,000 person-years, P = 0.23). At year 4, cumulative varicella incidence was 0.27% for IBD and 0.18% for non-IBD ( P = 0.24). No hospitalizations or deaths occurred.
期刊介绍：
Published on behalf of the American College of Gastroenterology (ACG), The American Journal of Gastroenterology (AJG) stands as the foremost clinical journal in the fields of gastroenterology and hepatology. AJG offers practical and professional support to clinicians addressing the most prevalent gastroenterological disorders in patients.
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