Programmable production of bioactive extracellular vesicles in vivo to treat myocardial infarction

IF 15.7 1区综合性期刊 Q1 MULTIDISCIPLINARY SCIENCES Nature Communications Pub Date : 2025-03-25 DOI:10.1038/s41467-025-58260-0

Siyuan Fu, Zhiyu Wang, Peihong Huang, Guanjun Li, Jian Niu, Zhiyang Li, Guangyue Zu, Pengcheng Zhou, Lianhui Wang, David Tai Leong, Xianguang Ding

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Abstract

Current myocardial infarction (MI) treatment strategies remain challenged in suboptimal pharmacokinetics and potential adverse effects. Here we present a bioelectronic interface capable of producing on-demand abundant bioactive extracellular vesicles (EVs) near the MI area for in-situ localized treatment. The technology, termed electroactive patch for wirelessly and controllable EV generation (ePOWER), leverages wireless bioelectronic patch to stimulate embedded electrosensitive macrophages, actively modulating the biosynthesis of EVs and enabling EV production with high programmability to be delivered directly to the MI area. ~2400% more bioactive EVs were produced per cell under our ePOWER system. When surgically implanted, we demonstrate the therapeutic potential of in-situ EV production system to alleviate MI symptoms and improve cardiac function. This programmable ePOWER technology enables in-situ production of therapeutically rich EVs, thus reducing the need for exogenous cell expansion platforms and dedicated delivery, holding promise as a therapeutic all-in-one platform to treat various diseases.

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体内可编程生产生物活性细胞外囊泡治疗心肌梗死

目前的心肌梗死（MI）治疗策略在次优药代动力学和潜在的不良反应方面仍然受到挑战。在这里，我们提出了一种生物电子界面，能够在MI区域附近按需产生丰富的生物活性细胞外囊泡（ev），用于原位定位治疗。这项技术被称为电活性贴片，用于无线和可控电动汽车生产（ePOWER），利用无线生物电子贴片刺激嵌入的电敏感巨噬细胞，主动调节电动汽车的生物合成，并使具有高可编程性的电动汽车生产直接输送到心肌区域。在我们的ePOWER系统下，每个细胞产生的生物活性ev增加了~2400%。当手术植入时，我们证明了原位EV产生系统在缓解心肌梗死症状和改善心功能方面的治疗潜力。这种可编程的ePOWER技术能够原位生产具有丰富治疗意义的电动汽车，从而减少了对外源性细胞扩增平台和专用输送的需求，有望成为治疗各种疾病的多功能治疗平台。

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来源期刊

Nature Communications Biological Science Disciplines-

CiteScore

24.90

自引率

2.40%

发文量

6928

审稿时长

3.7 months

期刊介绍： Nature Communications, an open-access journal, publishes high-quality research spanning all areas of the natural sciences. Papers featured in the journal showcase significant advances relevant to specialists in each respective field. With a 2-year impact factor of 16.6 (2022) and a median time of 8 days from submission to the first editorial decision, Nature Communications is committed to rapid dissemination of research findings. As a multidisciplinary journal, it welcomes contributions from biological, health, physical, chemical, Earth, social, mathematical, applied, and engineering sciences, aiming to highlight important breakthroughs within each domain.