MIF, a previously unrecognized pituitary hormone and macrophage cytokine, is a pivotal mediator in endotoxic shock.

Circulatory shock Pub Date : 1994-09-01
R Bucala
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Abstract

Recent studies have led to the re-discovery of the protein originally described as macrophage-migration inhibitory factor (MIF) to be both a pituitary hormone and a pro-inflammatory, macrophage cytokine. MIF is a pivotal mediator in endotoxic shock and may serve as a pituitary "stress" hormone that regulates systemic inflammatory responses.

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MIF是一种以前未被认识的垂体激素和巨噬细胞细胞因子,是内源性休克的关键介质。
最近的研究重新发现,最初被描述为巨噬细胞迁移抑制因子(MIF)的蛋白质既是一种垂体激素,也是一种促炎的巨噬细胞因子。MIF是内源性休克的关键介质,可能作为调节全身炎症反应的垂体“应激”激素。
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