Intrinsic pumping of mesenteric lymphatics is increased after hemorrhage in awake sheep.

Circulatory shock Pub Date : 1994-06-01
B R Boulanger, S J Lloyd, M Walker, M G Johnston
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Abstract

Lymphatic vessels have the ability to contract and transport liquid and protein from tissue spaces to the intravascular space. The purpose of this investigation was to test whether this lymph pump is stimulated following a fixed volume hemorrhage in awake sheep. To quantitate lymphatic pumping in vivo, a mesenteric lymphatic was isolated from all lymph input and provided with Krebs solution at a fixed transmural pressure. A branch of the mesenteric duct was cannulated to provide a measure of lymph flow rate. Each animal was either bled 25% of blood volume over 5 min or was observed. Systemic arterial blood pressure declined in all bled sheep (P < 0.05). Hemorrhage had no effect on lymph flow from mesenteric ducts. However, hemorrhage significantly enhanced lymphatic pumping, approximately 200% of control values 3 hr after hemorrhage (P < 0.01). Increased lymphatic pumping after hemorrhage may play an important role in blood volume and protein restitution.

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清醒绵羊出血后肠系膜淋巴管的内在泵送增加。
淋巴管具有收缩和将液体和蛋白质从组织空间输送到血管内空间的能力。本研究的目的是测试在清醒的绵羊发生固定容量出血后,淋巴泵是否受到刺激。为了量化体内淋巴泵送,从所有淋巴输入中分离出肠系膜淋巴,并在固定的跨壁压力下提供Krebs溶液。肠系膜导管的一个分支被插管以提供淋巴流速的测量。每只动物要么在5分钟内放出25%的血容量,要么进行观察。所有出血羊的全身动脉血压均下降(P < 0.05)。出血对肠系膜导管的淋巴流动无影响。然而,出血显著增强淋巴泵送,出血后3小时约为对照组的200% (P < 0.01)。出血后淋巴泵的增加可能在血容量和蛋白质恢复中起重要作用。
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