Lung and systemic oxidant and antioxidant activity after graded smoke exposure in the rat.

Circulatory shock Pub Date : 1994-01-01
C Lalonde, L Picard, C Campbell, R Demling
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Abstract

We wanted to determine the effect of a graded smoke inhalation on lung and systemic oxidant stress, and its relationship to physiological and histological change. Male Wistar rats were given 12 breaths of 10 ml/kg (n = 8) (group 1) or 20 ml/kg (n = 8) (group 2) tidal volume, using cotton toweling smoke through the trachea using positive pressure. Rats were monitored, then killed at 24 hr. Data were compared to controls (n = 8). Peak group 1 and group 2 carboxyhemoglobins were 22 +/- 6 and 46 +/- 6%, with a mortality prior to 24 hr of 14% and 50%, respectively. Group 1 rats showed only moderate lung dysfunction but with severe airway inflammation and edema, alveolar inflammation and atelectasis, with a decrease in PaO2 from the control of 96 +/- 4 to 72 +/- 5 torr. No increase in lung, liver, or kidney oxidant-induced lipid peroxidation, measured as malondialdehyde lung, liver, or kidney oxidant-induced lipid peroxidation, measured as malondialdehyde (MDA), or decrease in the antioxidant defenses catalase was noted. Group 2 rats demonstrated severe airways edema, alveolar atelectasis, and alveolar edema, and a PaO2 decreasing below 60 torr, corresponding with a 3-fold increase in lung tissue MDA and 35% decrease in catalase. In addition, liver and kidney tissue MDA doubled, and catalase activity decreased by 40%. Increased oxygen consumption was also demonstrated.(ABSTRACT TRUNCATED AT 250 WORDS)

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分级烟雾暴露后大鼠肺和全身的氧化和抗氧化活性。
我们想要确定分级烟雾吸入对肺和全身氧化应激的影响,以及它与生理和组织学变化的关系。雄性Wistar大鼠按潮气量10 ml/kg (n = 8)(1组)或20 ml/kg (n = 8)(2组)呼吸12次,用棉毛巾正压吸烟通过气管。对大鼠进行监测,并于24小时处死。将数据与对照组(n = 8)进行比较。峰值组1和组2的羧血红蛋白分别为22 +/- 6%和46 +/- 6%,24小时前死亡率分别为14%和50%。1组大鼠仅出现中度肺功能障碍,但出现严重的气道炎症和水肿、肺泡炎症和肺不张,PaO2较对照组(96 +/- 4)下降至72 +/- 5 torr。肺、肝或肾氧化剂诱导的脂质过氧化(以丙二醛测量)没有增加,肺、肝或肾氧化剂诱导的脂质过氧化(以丙二醛(MDA)测量)也没有减少抗氧化防御过氧化氢酶。2组大鼠出现严重气道水肿、肺泡不张、肺泡水肿,PaO2降至60 torr以下,肺组织MDA升高3倍,过氧化氢酶降低35%。肝脏和肾脏组织MDA增加一倍,过氧化氢酶活性降低40%。氧气消耗也增加了。(摘要删节250字)
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