NTP technical report on the toxicity studies of Ethylbenzene (Cas No. 100-41-4) in F344/N Rats and B6C3F1 Mice (Inhalation Studies).

Toxicity report series Pub Date : 1992-03-01
Po Chan
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Abstract

Ethylbenzene is commonly used as a solvent and chemical intermediate and as an additive in some motor fuel formulations. Inhalation toxicology studies of ethylbenzene (99% pure) were conducted by exposing groups of F344/N rats and B6C3F1 mice of each sex to ethylbenzene vapor at chamber concentrations of 0, 100, 250, 500, 750, or 1000 ppm, 6 hours per day, 5 days per week for 13 weeks. No rats or mice died during the 13-week exposure. Body weight gains were slightly lower in the high dose groups of male and female rats, but the differences were not statistically significant. Absolute and relative kidney, liver, and lung weights were increased in the exposed rats, while weight increases occurred only in the livers of exposed mice. Chemically related histopathologic changes were not observed in any tissues of rats or mice. No changes were observed in the evaluation of sperm or vaginal cytology in rats or mice. Ethylbenzene was not mutagenic in Salmonella and did not induce chromosomal aberrations or sister chromatid exchanges in Chinese hamster ovary (CHO) cells in vitro, though it did induce trifluorothymidine resistance in mouse lymphoma cells at the highest concentration tested. Micronuclei assays in peripheral blood of mice were negative. Thus, there appears to be only minimal evidence of toxicity in F344/N rats and B6C3F1 mice exposed to ethylbenzene by inhalation at concentrations as high as to 1000 ppm for 13 weeks. Synonyms: EB, ethyl benzene, ethylbenzol, phenylethane. (NOTE: These studies were supported in part by funds from the Comprehensive Environmental Response, Compensation, and Liability Act trust fund (Superfund) by an interagency agreement with the Agency for Toxic Substances and Disease Registry, U.S. Public Health Service.)

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国家毒理学NTP技术报告乙苯(Cas No. 100-41-4)对F344/N大鼠和B6C3F1小鼠的毒性研究(吸入研究)。
乙苯通常用作溶剂和化学中间体,并在某些发动机燃料配方中用作添加剂。通过将F344/N大鼠和B6C3F1小鼠各组暴露于室内浓度为0、100、250、500、750或1000 ppm的乙苯蒸气中,每天6小时,每周5天,持续13周,进行了乙苯(99%纯)的吸入毒理学研究。在13周的暴露期间,没有大鼠或小鼠死亡。高剂量组雄性和雌性大鼠的体重增加略低,但差异没有统计学意义。暴露大鼠的肾脏、肝脏和肺的绝对和相对重量增加,而暴露小鼠的肝脏只出现重量增加。在大鼠或小鼠的任何组织中均未观察到化学相关的组织病理学变化。在大鼠或小鼠的精子或阴道细胞学评估中未观察到变化。在体外实验中,乙苯对沙门氏菌没有诱变作用,也不会引起中国仓鼠卵巢(CHO)细胞的染色体畸变或姐妹染色单体交换,但在实验的最高浓度下,乙苯确实诱导小鼠淋巴瘤细胞对三氟胸腺嘧啶产生耐药性。小鼠外周血微核试验均为阴性。因此,在吸入浓度高达1000ppm的乙苯13周后,F344/N大鼠和B6C3F1小鼠似乎只有极少的毒性证据。同义词:EB,乙苯,乙苯,苯乙烷。(注:这些研究的部分资金来自《综合环境反应、赔偿和责任法案》信托基金(超级基金),并与美国公共卫生服务局有毒物质和疾病登记处达成了机构间协议。)
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