Toxicity studies of sodium metavanadate and vanadyl sulfate administered in drinking water to Sprague Dawley (Hsd:Sprague Dawley SD) rats and B6C3F1/N mice.

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Abstract

Oral human exposure to vanadium may occur due to its presence in food and drinking water and its use in dietary supplements. The most prevalent oxidation states of vanadium in food and drinking water have been characterized as tetravalent and pentavalent. Vanadyl sulfate and sodium metavanadate were selected as representative tetravalent (V4+) and pentavalent (V5+) test articles for these studies, respectively. To assess the potential for oral toxicity of vanadium compounds with differing oxidation states under similar test conditions, the 3-month National Toxicology Program (NTP) toxicity studies of sodium metavanadate and vanadyl sulfate were conducted in male and female Sprague Dawley (Hsd:Sprague Dawley SD) rats (including perinatal exposure) and in B6C3F1/N mice. Drinking water concentrations for sodium metavanadate (0, 31.3, 62.5, 125, 250, and 500 mg/L) and vanadyl sulfate (0, 21.0, 41.9, 83.8, 168, and 335 mg/L) were selected on the basis of previously published 14-day drinking water studies conducted as part of the NTP vanadium research program. (Abstract Abridged).

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在饮用水中给 Sprague Dawley (Hsd:Sprague Dawley SD) 大鼠和 B6C3F1/N 小鼠施用偏钒酸钠和硫酸香草酯的毒性研究。
由于钒存在于食物和饮用水中以及被用于膳食补充剂,人类可能会经口摄入钒。食物和饮用水中最常见的钒氧化态被描述为四价和五价。在这些研究中,硫酸钒和偏钒酸钠分别被选为具有代表性的四价(V4+)和五价(V5+)试验品。为了评估不同氧化态的钒化合物在类似试验条件下的口服毒性潜力,美国国家毒理学计划(NTP)对偏钒酸钠和硫酸钒进行了为期三个月的毒性研究,研究对象是雌雄Sprague Dawley(Hsd:Sprague Dawley SD)大鼠(包括围产期接触)和B6C3F1/N小鼠。偏钒酸钠(0、31.3、62.5、125、250 和 500 毫克/升)和硫酸钒(0、21.0、41.9、83.8、168 和 335 毫克/升)的饮用水浓度是根据先前公布的作为 NTP 钒研究计划一部分而进行的 14 天饮用水研究选定的。(摘要有删节)。
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