Toxicity studies of acetoin and 2,3-pentanedione administered by inhalation to Wistar Han [Crl:WI(Han)] rats and B6C3F1/N mice.

{"title":"Toxicity studies of acetoin and 2,3-pentanedione administered by inhalation to Wistar Han [Crl:WI(Han)] rats and B6C3F1/N mice.","authors":"","doi":"10.22427/NTP-TOX-98","DOIUrl":null,"url":null,"abstract":"<p><p>Acetoin and 2,3-pentanedione are highly volatile components of artificial butter flavoring (ABF). Concerns over the inhalation toxicity of these compounds originate from the association between occupational exposures to ABF and adverse fibrotic lung effects, specifically obliterative bronchiolitis (OB) in the distal airways. 2,3-Pentanedione has been used as a replacement for 2,3-butanedione (diacetyl) in some ABF due to concerns about the respiratory toxicity of 2,3-butanedione. However, 2,3-pentanedione is structurally similar to 2,3-butanedione and has been shown to exhibit potency similar to 2,3-butanedione regarding airway toxicity following acute inhalation (whole-body) exposure. This report describes a series of studies to evaluate the 2-week inhalation toxicity of acetoin and the 3-month inhalation toxicity of acetoin and 2,3-pentanedione. (Abstract Abridged).</p>","PeriodicalId":23116,"journal":{"name":"Toxicity report series","volume":" 98","pages":""},"PeriodicalIF":0.0000,"publicationDate":"2023-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10201376/pdf/","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Toxicity report series","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.22427/NTP-TOX-98","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
引用次数: 0

Abstract

Acetoin and 2,3-pentanedione are highly volatile components of artificial butter flavoring (ABF). Concerns over the inhalation toxicity of these compounds originate from the association between occupational exposures to ABF and adverse fibrotic lung effects, specifically obliterative bronchiolitis (OB) in the distal airways. 2,3-Pentanedione has been used as a replacement for 2,3-butanedione (diacetyl) in some ABF due to concerns about the respiratory toxicity of 2,3-butanedione. However, 2,3-pentanedione is structurally similar to 2,3-butanedione and has been shown to exhibit potency similar to 2,3-butanedione regarding airway toxicity following acute inhalation (whole-body) exposure. This report describes a series of studies to evaluate the 2-week inhalation toxicity of acetoin and the 3-month inhalation toxicity of acetoin and 2,3-pentanedione. (Abstract Abridged).

查看原文
分享 分享
微信好友 朋友圈 QQ好友 复制链接
本刊更多论文
以吸入方式给 Wistar Han [Crl:WI(Han)] 大鼠和 B6C3F1/N 小鼠注射乙炔和 2,3- 戊二酮的毒性研究。
乙酰丙酮和 2,3-戊二酮是人工黄油香精(ABF)中的高挥发性成分。人们之所以担心这些化合物的吸入毒性,是因为职业性接触 ABF 与肺部纤维化不良反应(特别是远端气道的阻塞性支气管炎 (OB))之间存在关联。由于担心 2,3-丁二酮的呼吸毒性,一些 ABF 已使用 2,3-戊二酮替代 2,3-丁二酮(二乙酰基)。不过,2,3-戊二酮在结构上与 2,3-丁二酮相似,而且在急性吸入(全身)接触后,其气道毒性与 2,3-丁二酮相似。本报告介绍了一系列研究,以评估乙炔醛 2 周吸入毒性以及乙炔醛和 2,3-戊二酮 3 个月吸入毒性。(摘要有删节)。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
求助全文
约1分钟内获得全文 去求助
来源期刊
自引率
0.00%
发文量
0
期刊最新文献
Toxicity studies of acetoin and 2,3-pentanedione administered by inhalation to Wistar Han [Crl:WI(Han)] rats and B6C3F1/N mice. Toxicity studies of sodium metavanadate and vanadyl sulfate administered in drinking water to Sprague Dawley (Hsd:Sprague Dawley SD) rats and B6C3F1/N mice. Toxicity studies of (+)-usnic acid administered in feed to F344/N Nctr rats and B6C3F1/Nctr mice. Toxicity studies of Usnea lichens containing (+/-)-usnic acid administered in feed to F344/N Nctr rats and B6C3F1/Nctr mice. Toxicity studies of trans-resveratrol administered by gavage for two weeks or three months to F344/NTac rats, Wistar Han [Crl:WI(Han)] rats, and B6C3F1/N mice.
×
引用
GB/T 7714-2015
复制
MLA
复制
APA
复制
导出至
BibTeX EndNote RefMan NoteFirst NoteExpress
×
×
提示
您的信息不完整,为了账户安全,请先补充。
现在去补充
×
提示
您因"违规操作"
具体请查看互助需知
我知道了
×
提示
现在去查看 取消
×
提示
确定
0
微信
客服QQ
Book学术公众号 扫码关注我们
反馈
×
意见反馈
请填写您的意见或建议
请填写您的手机或邮箱
已复制链接
已复制链接
快去分享给好友吧!
我知道了
×
扫码分享
扫码分享
Book学术官方微信
Book学术文献互助
Book学术文献互助群
群 号:481959085
Book学术
文献互助 智能选刊 最新文献 互助须知 联系我们:info@booksci.cn
Book学术提供免费学术资源搜索服务,方便国内外学者检索中英文文献。致力于提供最便捷和优质的服务体验。
Copyright © 2023 Book学术 All rights reserved.
ghs 京公网安备 11010802042870号 京ICP备2023020795号-1