NTP technical report on the toxicity studies of of n-Hexane in B6C3F1 Mice (Inhalation Studies) (CAS No. 110-54-3).

Toxicity report series Pub Date : 1991-01-01
June Dunnuck
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Abstract

Thirteen-week inhalation toxicity studies of n-hexane were conducted with B6C3F1 mice of each sex exposed to 0, 500, 1,000, 4,000, or 10,000 ppm, 6 hours per day, 5 days per week or to 1,000 ppm, 22 hours per day (referred to as 1,000c), 5 days per week. All mice lived to the end of the studies. The final mean body weights of mice exposed to 1,000c ppm or 10,000 ppm were 10% or 17% lower than that of the controls for males and 0% or 6% lower for females. Hematologic analyses were performed on whole blood samples collected at the end of the 13-week exposure. Segmented neutrophils were significantly increased in male mice exposed to 10,000 ppm. A battery of behavioral measurements was conducted on mice, and the only parameter affected was locomotor activity, which was decreased in female mice at 1,000c ppm and 10,000 ppm. The test battery performed included forelimb and hind limb grip strength, motor activity and exploratory behavior, acoustic startle response, foot splay, and analgesia response. Compound-related lesions of the nasal turbinates were seen in all groups of exposed mice except males exposed to 500 or 4,000 ppm. At the 10,000-ppm concentration, nasal lesions included inflammatory, erosive, and regenerative lesions of the olfactory and respiratory epithelium; luminal exudation and metaplastic lesions of the olfactory epithelium; and fibrosis of the submucosa. Lymphoid hyperplasia of the mandibular lymph nodes and neutrophilic hyperplasia of the bone marrow were also seen. At lower concentrations, lesions were not present in all mice and were limited to minimal regeneration or metaplasia of the olfactory epithelium. A few paranodal swellings in the teased fibers of the tibial nerve were observed in 3/4 males and 3/4 females exposed to 10,000 ppm, 3/4 males and 3/4 females exposed to 1,000c ppm, and 0/4 male and 0/4 female controls; the severity of the lesions was minimal. Neither segmental demyelination nor distal axonal degeneration was seen. Exposure of mice to n-hexane at concentrations up to 10,000 ppm resulted in only minimal toxicity. Paranodal swellings seen in nerves at 1,000c ppm and at 10,000 ppm were considered to be minimal nerve damage that would not result in paralysis. Exposure- related lesions of the nasal cavity occurred after n-hexane exposure, but minimal or no effects were seen at 1,000 ppm or below. Synonyms: Hexyl hydride. (NOTE: These studies were supported in part by funds from the Comprehensive Environmental Response, Compensation, and Liability Act trust fund (Superfund) by an interagency agreement with the Agency for Toxic Substances and Disease Registry, U.S. Public Health Service.)

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国家毒理学规划关于正己烷对B6C3F1小鼠毒性研究的技术报告(吸入研究)(CAS No. 110-54-3)。
对每一性别的B6C3F1小鼠进行了为期13周的正己烷吸入毒性研究,分别暴露于0,500,1,000,4,000或10,000 ppm,每天6小时,每周5天或暴露于1,000 ppm,每天22小时(称为1,000c),每周5天。所有的老鼠都活到了研究结束。暴露于1000ppm或10000ppm环境中的雄性小鼠的最终平均体重比对照组低10%或17%,雌性小鼠的最终平均体重比对照组低0%或6%。对13周暴露结束时收集的全血样本进行血液学分析。暴露于10,000 ppm的雄性小鼠中,节段性中性粒细胞显著增加。对小鼠进行了一系列行为测量,唯一受影响的参数是运动活动,雌性小鼠在1000ppm和10000ppm时运动活动减少。进行的测试包括前肢和后肢握力、运动活动和探索行为、声惊吓反应、足展和镇痛反应。除暴露于500或4,000 ppm的雄性小鼠外,所有暴露组小鼠的鼻甲骨均出现化合物相关病变。在10,000 ppm浓度下,鼻腔病变包括嗅觉上皮和呼吸上皮的炎症性、糜烂性和再生性病变;嗅上皮腔内渗出及化生病变;粘膜下层纤维化。下颌骨淋巴结淋巴样增生,骨髓嗜中性粒细胞增生。在较低浓度下,并非所有小鼠都出现病变,并且仅限于嗅觉上皮的最小再生或化生。在暴露于10,000 ppm的3/4男性和3/4女性中,暴露于1,000 ppm的3/4男性和3/4女性中,以及0/4男性和0/4女性对照中,观察到胫骨神经纤维的一些神经节旁肿胀;病变的严重程度很小。未见节段性脱髓鞘或远端轴突变性。将小鼠暴露于浓度高达10,000 ppm的正己烷中,只产生极小的毒性。在1000c ppm和10000ppm的浓度下,神经旁神经肿胀被认为是最小的神经损伤,不会导致瘫痪。正己烷暴露后发生鼻腔暴露相关病变,但1000ppm或以下的影响很小或没有影响。己基氢化物(注:这些研究的部分资金来自《综合环境反应、赔偿和责任法案》信托基金(超级基金),并与美国公共卫生服务局有毒物质和疾病登记处达成了机构间协议。)
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