[Effect of Astragalus membranaceus injection on megakaryocyte hematopoiesis in anemic mice].

Hua xi yi ke da xue xue bao = Journal of West China University of Medical Sciences = Huaxi yike daxue xuebao Pub Date : 2001-12-01

X Zhu, B Zhu

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Abstract

Objective: To assess the effect of Astragalus membranaceus injection (AMI) on megakaryocyte hematopoiesis in anemic mice and explore its mechanism.

Methods: Anemic models of mice were randomly divided into two groups: treatment group and anemic control group. Intraperitoneal doses of AMI (20 mg/(ml.20 g) q.d x 6) were given to the treatment group, and equal doses of physiological saline were given to the anemic control group. On days 8, 11 and 14 after treatment, blood platelet and bone marrow cells were determined, and the numbers of CFU-Meg (colony forming unit-megakaryocyte) and Meg-CSA (megakaryocyte colony-stimulating activity) were determined by using technique of hematopoietic progenitor cells culture in vitro.

Results: Serum Meg-CSA of the treatment group was significantly higher than that of the anemic control group. The abovementioned indices of the treatment group recovered to normal by day 11, which was markedly earlier than the day of recovery observed in the anemic control group.

Conclusion: AMI can increase serum Meg-CSA of anemic mice and accelerate the recovery of megekaryocyte hematopoiesis after bone marrow suppression.

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[黄芪注射液对贫血小鼠巨核细胞造血的影响]。

目的:观察黄芪注射液对贫血小鼠巨核细胞造血功能的影响并探讨其作用机制。方法:将小鼠贫血模型随机分为治疗组和贫血对照组。AMI腹腔注射剂量为20mg /(ml。治疗组给予20 g (q.d × 6)，贫血对照组给予等量生理盐水。在治疗后第8、11、14天测定血小板和骨髓细胞，并采用体外造血祖细胞培养技术测定巨核细胞集落形成单位(CFU-Meg)和巨核细胞集落刺激活性(Meg-CSA)。结果:治疗组血清mg - csa明显高于贫血对照组。治疗组上述指标均于第11天恢复正常，明显早于贫血对照组。结论:AMI能提高贫血小鼠血清Meg-CSA，加速骨髓抑制后巨核细胞造血功能的恢复。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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Hua xi yi ke da xue xue bao = Journal of West China University of Medical Sciences = Huaxi yike daxue xuebao

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