[Multicenter evaluation on the efficacy and safety of sparfloxacin in the treatment of acute bacterial infections].

Hua xi yi ke da xue xue bao = Journal of West China University of Medical Sciences = Huaxi yike daxue xuebao Pub Date : 2002-04-01

Yongning Cai, Derong Liang, Nan Xu, Jia Miao, Dungong Qiu, Chonglin Wen

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Abstract

Objective: To evaluate the efficacy and safety of domestic sparfloxacin.

Methods: A multicentre randomized controlled clinical trial was conducted to compare sparfloxacin versus ofloxacin in the treatment of acute bacterial infections. 58 patients received 200 mg of sparfloxacin once daily intravenous drip and 61 patients received 200 mg of ofloxacin twice daily intravenous drip. Both drugs were given for 7-14 days.

Results: The clinical cure rates of sparfloxacin group and ofloxacin group were 44.83% and 42.62%, and the efficacy rates were 87.93% and 81.97%, respectively; no significant differences were noted between the two groups (P > 0.05). The bacterial eradication rates were 86.00% and 84.62% respectively (P > 0.05). The adverse reactions in the two groups were 13.79% and 22.58% (P > 0.05). Photosensitivity reaction was not observed in this study.

Conclusion: Domestic sparfloxacin is effective and safe in treating acute bacterial infections.

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【司帕沙星治疗急性细菌感染的疗效和安全性多中心评价】。

目的:评价国产司帕沙星的疗效和安全性。方法:采用多中心随机对照临床试验，比较司帕沙星与氧氟沙星治疗急性细菌感染的疗效。58例患者给予司帕沙星200 mg / d静脉滴注，61例患者给予氧氟沙星200 mg / d静脉滴注。两种药物均给药7 ~ 14天。结果:司帕沙星组和氧氟沙星组临床治愈率分别为44.83%和42.62%，有效率分别为87.93%和81.97%;两组间差异无统计学意义(P > 0.05)。细菌根除率分别为86.00%和84.62% (P > 0.05)。两组不良反应发生率分别为13.79%和22.58% (P > 0.05)。本研究未见光敏反应。结论:国产司帕沙星治疗急性细菌感染安全有效。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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Hua xi yi ke da xue xue bao = Journal of West China University of Medical Sciences = Huaxi yike daxue xuebao

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