{"title":"Determination of prednisolone in the presence of hydroxyzine and in formulations containing analgesics","authors":"J.D. Duerr , B.A. Pappas","doi":"10.1002/jps.3030491206","DOIUrl":null,"url":null,"abstract":"<div><p>A colorimetric method for the determination of prednisolone in the presence of hydroxyzine [1-(<em>p</em>-chlorobenzhydryl)-4-2-(2-hydroxyethoxy) ethyl piperazine], acetylsalicylic acid, caffeine, and acetophenetidin is proposed. Samples of tablet formulations containing prednisolone and the above mentioned compounds were assayed by the addition of sulfuric acid and ferric chloride to alcoholic solutions of the active ingredient and subsequent measurement of the absorbance of the resulting colored solutions.</p></div>","PeriodicalId":100839,"journal":{"name":"Journal of the American Pharmaceutical Association (Scientific ed.)","volume":"49 12","pages":"Pages 759-761"},"PeriodicalIF":0.0000,"publicationDate":"1960-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1002/jps.3030491206","citationCount":"1","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Journal of the American Pharmaceutical Association (Scientific ed.)","FirstCategoryId":"1085","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S0095955315300068","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
引用次数: 1
Abstract
A colorimetric method for the determination of prednisolone in the presence of hydroxyzine [1-(p-chlorobenzhydryl)-4-2-(2-hydroxyethoxy) ethyl piperazine], acetylsalicylic acid, caffeine, and acetophenetidin is proposed. Samples of tablet formulations containing prednisolone and the above mentioned compounds were assayed by the addition of sulfuric acid and ferric chloride to alcoholic solutions of the active ingredient and subsequent measurement of the absorbance of the resulting colored solutions.
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