Toxicity studies of α-pinene administered by inhalation to F344/N rats and B6C3F1/N mice.

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Abstract

α-Pinene is the main component in turpentine and is used as a fragrance and flavoring ingredient. Due to widespread exposure potential and a lack of available toxicity data, male and female F344/N rats and B6C3F1/N mice were exposed to α-pinene (96% pure) by inhalation for 2 weeks or 3 months. Genetic toxicology studies were conducted in Salmonella typhimurium, Escherichia coli, and mouse peripheral blood erythrocytes. (Abstract Abridged).

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F344/N 大鼠和 B6C3F1/N 小鼠吸入 α-蒎烯的毒性研究。
α-蒎烯是松节油的主要成分,可用作香料和调味料。由于α-蒎烯具有广泛的接触潜力,而且缺乏可用的毒性数据,因此,雌雄 F344/N 大鼠和 B6C3F1/N 小鼠通过吸入α-蒎烯(纯度为 96%)进行了为期 2 周或 3 个月的接触。在鼠伤寒沙门氏菌、大肠杆菌和小鼠外周血红细胞中进行了遗传毒理学研究。(摘要有删节)。
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