{"title":"Toxicity studies of o-chloropyridine administered dermally and in drinking water to F344/N rats and B6C3F1/N mice.","authors":"","doi":"10.22427/NTP-TOX-83","DOIUrl":null,"url":null,"abstract":"<p><p>o-Chloropyridine is used as an intermediate in synthetic organic, pharmaceutical, and agricultural chemical (fungicides, herbicides) manufacture. It is also used as a catalyst for phase transfer and is a key intermediate in the manufacture of pyrithione-based biocides for use in cosmetics and various pharmaceutical products. o-Chloropyridine is available in purified (99%), technical (95%), or crude (80%) grades. o-Chloropyridine was nominated for testing by the NTP based on increasing production and use as a site-limited pharmaceutical and agrochemical intermediate, the potential for occupational and environmental exposures during its manufacture, its persistence in the environment (lasting longer than 6 months), evidence of mutagenicity based on results of several short-term test systems, and suspicion of carcinogenicity based on effects associated with structurally related chemicals. Male and female F344/N rats and B6C3F1/N mice received o-chloropyridine (99% pure) dermally for 2 weeks or in drinking water for 3 months. Genetic toxicology studies were conducted in Salmonella typhimurium and mouse peripheral blood erythrocytes. (Abstract Abridged).</p>","PeriodicalId":23116,"journal":{"name":"Toxicity report series","volume":" 83","pages":""},"PeriodicalIF":0.0000,"publicationDate":"2017-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8039870/pdf/","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Toxicity report series","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.22427/NTP-TOX-83","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
引用次数: 0
Abstract
o-Chloropyridine is used as an intermediate in synthetic organic, pharmaceutical, and agricultural chemical (fungicides, herbicides) manufacture. It is also used as a catalyst for phase transfer and is a key intermediate in the manufacture of pyrithione-based biocides for use in cosmetics and various pharmaceutical products. o-Chloropyridine is available in purified (99%), technical (95%), or crude (80%) grades. o-Chloropyridine was nominated for testing by the NTP based on increasing production and use as a site-limited pharmaceutical and agrochemical intermediate, the potential for occupational and environmental exposures during its manufacture, its persistence in the environment (lasting longer than 6 months), evidence of mutagenicity based on results of several short-term test systems, and suspicion of carcinogenicity based on effects associated with structurally related chemicals. Male and female F344/N rats and B6C3F1/N mice received o-chloropyridine (99% pure) dermally for 2 weeks or in drinking water for 3 months. Genetic toxicology studies were conducted in Salmonella typhimurium and mouse peripheral blood erythrocytes. (Abstract Abridged).