Toxicity studies of perfluoroalkyl sulfonates administered by gavage to Sprague Dawley (Hsd:Sprague Dawley SD) rats (revised).

Abstract

Widespread exposure to several per/polyfluorinated alkyl substances (PFAS) is associated with a variety of toxicities that include liver and endocrine toxicity. The National Toxicology Program (NTP) conducted 28-day toxicity studies in male and female Sprague Dawley (Hsd:Sprague Dawley SD) rats (n = 10/dose; five doses per chemical) to compare the toxicities of seven PFAS (three sulfonic acids or salt: perfluorobutane sulfonic acid [PFBS], perfluorohexane sulfonate potassium salt [PFHxSK], and perfluorooctane sulfonic acid [PFOS], and four carboxylates) via gavage in deionized water with 2% Tween 80. This report describes the studies for the two sulfonic acids (PFBS and PFOS) and salt (PFHxSK); a companion report (NTP Toxicity Study Report 97) describes the studies for the PFAS carboxylates. Doses were 0 to 1,000 mg/kg/day for PFBS, 0 to 10 mg/kg/day for PFHxSK males, 0 to 50 mg/kg/day for PFHxSK females, and 0 to 5 mg/kg/day for PFOS. (Abstract Abridged).