How Can a Multidisciplinary Approach Improve Prognosis of Soft-Tissue Sarcomas of Extremities?

IF 1.6 Q4 ONCOLOGY International Journal of Surgical Oncology Pub Date : 2021-03-24 eCollection Date: 2021-01-01 DOI:10.1155/2021/8871557
Asmae Mazti, Mohamed El Idrissi, Abdelhalim El Ibrahimi, Mustapha El Maaroufi, Ghizlane El Koubaiti, Touria Bouhafa, Samira El Fakir, Samia Arifi, Abdelmajid Mrini, Laila Chbani
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引用次数: 2

Abstract

Soft-tissue sarcomas are malignant tumors that require good management within specialized centers. Our study aims to assess the benefit of handling these kinds of tumors using the Multidisciplinary Meeting (MDM) approach. The current paper details this approach through a prospective study that has lasted for 42 months in the HASSAN II University Hospital Center, Fez, Morocco. During this research work, 116 cases were selected with an average age of 53 years. In 95.7% of the cases, it was found that the lower limb was the most frequent tumor type (78.4%). Also, ninety-two (92) patients (79.3%) have had a prior biopsy. Ninety-nine (99) patients (85.3%) have received a magnetic resonance imaging scan (MRI) before surgery. Sixty-three (63) patients were operated on, including R0 resection used for 37 patients, R1 used for 21 patients, and R2 used for five patients. As a result, liposarcomas were the most frequent type (30.1%), followed by synovial sarcomas (14.6%), leiomyosarcomas (9.5%), ewing sarcoma (8.6), and undifferentiated pleomorphic sarcomas (7.7%). In addition, neoadjuvant chemotherapy was used for 36 patients. The other 22 patients received adjuvant chemotherapy and/or radiotherapy. The overall survival rate was 60.56 months, which proves a significant improvement, thanks to the multidisciplinary meeting approach. Conclusion. The conducted investigation has shown that using MDM for managing soft-tissue sarcomas of extremities improves the patients' survival rate. Moreover, results have proven MDM might allow optimal treatment regarding less local recurrence and metastasis.

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多学科联合治疗如何改善四肢软组织肉瘤的预后?
软组织肉瘤是恶性肿瘤,需要在专门的中心进行良好的治疗。我们的研究旨在评估使用多学科会议(MDM)方法处理这类肿瘤的益处。本文通过一项在摩洛哥非斯的哈桑二世大学医院中心持续42个月的前瞻性研究详细介绍了这种方法。本研究共选取116例,平均年龄53岁。在95.7%的病例中,发现下肢是最常见的肿瘤类型(78.4%)。此外,92例(79.3%)患者既往有活检。99例(85.3%)患者在手术前接受了磁共振成像扫描(MRI)。共手术63例,其中R0切除37例,R1切除21例,R2切除5例。结果,脂肪肉瘤是最常见的类型(30.1%),其次是滑膜肉瘤(14.6%)、平滑肌肉瘤(9.5%)、尤文氏肉瘤(8.6)和未分化多形性肉瘤(7.7%)。另外,36例患者接受了新辅助化疗。其余22例患者接受辅助化疗和/或放疗。总生存率为60.56个月,由于多学科会议的方法,这证明了显着的改善。结论。研究表明,使用MDM治疗四肢软组织肉瘤可提高患者的生存率。此外,研究结果表明,MDM可以减少局部复发和转移,从而实现最佳治疗。
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来源期刊
CiteScore
3.70
自引率
0.00%
发文量
5
审稿时长
20 weeks
期刊介绍: International Journal of Surgical Oncology is a peer-reviewed, Open Access journal that publishes original research articles, review articles, and clinical studies in all areas of surgical oncology.
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