A novel electrochemical sensor based on electrospun TiO2 nanoparticles/carbon nanofibers for determination of Idarubicin in biological samples

IF 4.1 3区化学 Q1 CHEMISTRY, ANALYTICAL Journal of Electroanalytical Chemistry Pub Date : 2017-09-15 DOI:10.1016/j.jelechem.2017.08.034

Elham Arkan , Giti Paimard , Khalil Moradi

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引用次数: 0

Abstract

A novel electrochemical sensor based on a carbon paste electrode modified with electrospun carbon nanofibers and TiO₂ nanoparticles was prepared. It was designed to electrochemical determination of Idarubicin (IDA) in biological samples. To this end, carbon nanofibers were prepared by electrospinning process from polyacrylonitrile (PAN) and then modified with TiO₂ nanoparticles. Scanning electron microscopy (SEM) and electrochemical impedance spectroscopy (EIS) techniques were employed for characterization of the various nanocomposite modified electrode. The results revealed that the modified electrodes showed an obvious electrocatalytic activity toward the oxidation of IDA by a remarkable enhancement in the current response compared with bare electrode. The modified electrode was applied to determine of IDA with square wave voltammetry (SWV) technique. Under optimized conditions, IDA gave a linear response in the concentration range of 0.012 to 10.0 μM with the detection limit of 3 nM. Interfering species of other anticancer drug such as doxorubicin, epirubicin and daunorubicin showed no interference with the selective determination of IDA. The finding suggests that the mentioned method was completely validated and successfully applied for the determination of IDA in real samples such as serum.

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基于纳米二氧化钛/纳米碳纤维的电化学传感器用于生物样品中伊达柔比星的检测

制备了一种基于电纺碳纳米纤维和TiO2纳米粒子修饰的碳糊电极的新型电化学传感器。建立了电化学测定生物样品中伊达柔比星(IDA)的方法。为此，以聚丙烯腈(PAN)为原料，采用静电纺丝法制备了碳纳米纤维，并用TiO2纳米粒子进行改性。采用扫描电镜(SEM)和电化学阻抗谱(EIS)技术对各种纳米复合材料修饰电极进行了表征。结果表明，与裸电极相比，修饰电极对IDA的氧化表现出明显的电催化活性，电流响应显著增强。将该修饰电极用于方波伏安法(SWV)测定IDA。在优化条件下，IDA在0.012 ~ 10.0 μM的浓度范围内呈线性响应，检出限为3 nM。其他抗癌药如阿霉素、表阿霉素和柔红霉素的干扰种对IDA的选择性测定无干扰。结果表明，该方法完全有效，可成功应用于血清等实际样品中IDA的测定。

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IF 3.9 3区医学EyePub Date : 1993-01-01 DOI: 10.1038/eye.1993.36

L Esakowitz, A Kriss, F Shawkat

The repeatability and variability of the multifocal electroretinogram for four different electrodes.

IF 2.9 3区医学Ophthalmic and Physiological OpticsPub Date : 1997-11-01 DOI:

N Mohidin, M K Yap, R J Jacobs

The repeatability and variability of the multifocal electroretinogram for four different electrodes

IF 2.9 3区医学Ophthalmic and Physiological OpticsPub Date : 1997-11-01 DOI: 10.1016/S0275-5408(97)00034-3

N. Mohidin, M.K.H. Yap , R.J. Jacobs

来源期刊

Journal of Electroanalytical Chemistry 化学-电化学

CiteScore

7.80

自引率

6.70%

发文量

912

审稿时长

2.4 months

期刊介绍： The Journal of Electroanalytical Chemistry is the foremost international journal devoted to the interdisciplinary subject of electrochemistry in all its aspects, theoretical as well as applied. Electrochemistry is a wide ranging area that is in a state of continuous evolution. Rather than compiling a long list of topics covered by the Journal, the editors would like to draw particular attention to the key issues of novelty, topicality and quality. Papers should present new and interesting electrochemical science in a way that is accessible to the reader. The presentation and discussion should be at a level that is consistent with the international status of the Journal. Reports describing the application of well-established techniques to problems that are essentially technical will not be accepted. Similarly, papers that report observations but fail to provide adequate interpretation will be rejected by the Editors. Papers dealing with technical electrochemistry should be submitted to other specialist journals unless the authors can show that their work provides substantially new insights into electrochemical processes.