Chili-supplemented food decreases glutathione-S-transferase activity in Drosophila melanogaster females without a change in other parameters of antioxidant system.

IF 5.2 2区生物学 Q1 BIOCHEMISTRY & MOLECULAR BIOLOGY Redox Report Pub Date : 2022-12-01 DOI:10.1080/13510002.2022.2123884

Uliana V Semaniuk, Dmytro V Gospodaryov, Olha M Strilbytska, Alicja Z Kucharska, Anna Sokół-Łętowska, Nadia I Burdyliuk, Kenneth B Storey, Maria M Bayliak, Oleh Lushchak

{"title":"Chili-supplemented food decreases glutathione-S-transferase activity in Drosophila melanogaster females without a change in other parameters of antioxidant system.","authors":"Uliana V Semaniuk, Dmytro V Gospodaryov, Olha M Strilbytska, Alicja Z Kucharska, Anna Sokół-Łętowska, Nadia I Burdyliuk, Kenneth B Storey, Maria M Bayliak, Oleh Lushchak","doi":"10.1080/13510002.2022.2123884","DOIUrl":null,"url":null,"abstract":"Objectives: Many plant-derived anti-aging preparations influence antioxidant defense system. Consumption of food supplemented with chili pepper powder was found to extend lifespan in the fruit fly, Drosophila melanogaster. The present study aimed to test a connection between life-extending effect of chili powder and antioxidant defense system of D. melanogaster.Methods: Flies were reared for 15 days in the mortality cages on food with 0% (control), 0.04%, 0.12%, 0.4%, or 3% chili powder. Antioxidant and related enzymes, as well as oxidative stress indices were measured.Results: Female flies that consumed chili-supplemented food had a 40-60% lower glutathione-S-transferase (GST) activity as compared with the control cohort. Activity of superoxide dismutase (SOD) was about 37% higher in males that consumed food with 3% chili powder in comparison with the control cohort. Many of the parameters studied were sex-dependent.Conclusions: Consumption of chili-supplemented food extends lifespan in fruit fly cohorts in a concentration- and gender-dependent manner. However, this extension is not mediated by a strengthening of antioxidant defenses. Consumption of chili-supplemented food does not change the specific relationship between antioxidant and related enzymes in D. melanogaster, and does not change the linkage of the activities of these enzymes to fly gender.","PeriodicalId":21096,"journal":{"name":"Redox Report","volume":null,"pages":null},"PeriodicalIF":5.2000,"publicationDate":"2022-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9553170/pdf/","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Redox Report","FirstCategoryId":"99","ListUrlMain":"https://doi.org/10.1080/13510002.2022.2123884","RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"BIOCHEMISTRY & MOLECULAR BIOLOGY","Score":null,"Total":0}

引用次数: 0

Abstract

Objectives: Many plant-derived anti-aging preparations influence antioxidant defense system. Consumption of food supplemented with chili pepper powder was found to extend lifespan in the fruit fly, Drosophila melanogaster. The present study aimed to test a connection between life-extending effect of chili powder and antioxidant defense system of D. melanogaster.

Methods: Flies were reared for 15 days in the mortality cages on food with 0% (control), 0.04%, 0.12%, 0.4%, or 3% chili powder. Antioxidant and related enzymes, as well as oxidative stress indices were measured.

Results: Female flies that consumed chili-supplemented food had a 40-60% lower glutathione-S-transferase (GST) activity as compared with the control cohort. Activity of superoxide dismutase (SOD) was about 37% higher in males that consumed food with 3% chili powder in comparison with the control cohort. Many of the parameters studied were sex-dependent.

Conclusions: Consumption of chili-supplemented food extends lifespan in fruit fly cohorts in a concentration- and gender-dependent manner. However, this extension is not mediated by a strengthening of antioxidant defenses. Consumption of chili-supplemented food does not change the specific relationship between antioxidant and related enzymes in D. melanogaster, and does not change the linkage of the activities of these enzymes to fly gender.

Abstract Image

查看原文

微信好友朋友圈 QQ好友复制链接

本刊更多论文

添加辣椒可降低雌性黑腹果蝇的谷胱甘肽-s -转移酶活性，但其他抗氧化系统参数未发生变化。

目的:许多植物源性抗衰老制剂影响抗氧化防御系统。研究发现，食用含有辣椒粉的食物可以延长果蝇的寿命。本研究旨在探讨辣椒粉的延寿作用与黑腹龙抗氧化防御系统之间的关系。方法:分别饲喂0%(对照)、0.04%、0.12%、0.4%、3%辣椒粉的死亡笼，饲养15 d。测定抗氧化及相关酶、氧化应激指标。结果:食用辣椒补充食物的雌性果蝇的谷胱甘肽-s -转移酶(GST)活性比对照组低40-60%。与对照组相比，食用含有3%辣椒粉的食物的男性的超氧化物歧化酶(SOD)活性高出约37%。研究的许多参数都与性别有关。结论:食用辣椒补充食物可延长果蝇种群的寿命，并具有浓度依赖性和性别依赖性。然而，这种扩展不是通过增强抗氧化防御来介导的。食用辣椒类食物不会改变黑腹扁蝇抗氧化酶与相关酶之间的特定关系，也不会改变这些酶的活性与果蝇性别的联系。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

求助全文

约1分钟内获得全文去求助

来源期刊

Redox Report 生物-生化与分子生物学

CiteScore

6.10

自引率

0.00%

发文量

审稿时长

>12 weeks

期刊介绍： Redox Report is a multidisciplinary peer-reviewed open access journal focusing on the role of free radicals, oxidative stress, activated oxygen, perioxidative and redox processes, primarily in the human environment and human pathology. Relevant papers on the animal and plant environment, biology and pathology will also be included. While emphasis is placed upon methodological and intellectual advances underpinned by new data, the journal offers scope for review, hypotheses, critiques and other forms of discussion.