Feasibility of Single-Input Tracer Kinetic Modeling with Continuous-Time Formalism in Liver 4-Phase Dynamic Contrast-Enhanced CT.

Abdominal imaging : computational and clinical applications : 6th International Workshop, ABDI 2014, held in conjunction with MICCAI 2014, Cambridge, MA, USA, September 14, 2014. ABDI (Workshop) (6th : 2014 : Cambridge, Mass.) Pub Date : 2014-09-01 DOI:10.1007/978-3-319-13692-9_6

Sang Ho Lee, Yasuji Ryu, Koichi Hayano, Hiroyuki Yoshida

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Abstract

The modeling of tracer kinetics with use of low-temporal-resolution data is of central importance for patient dose reduction in dynamic contrast-enhanced CT (DCE-CT) study. Tracer kinetic models of the liver vary according to the physiologic assumptions imposed on the model, and they can substantially differ in the ways how the input for blood supply and tissue compartments are modeled. In this study, single-input flow-limited (FL), Tofts-Kety (TK), extended TK (ETK), Hayton-Brady (HB), two compartment exchange (2CX), and adiabatic approximation to the tissue homogeneity (AATH) models were applied to the analysis of liver 4-phase DCE-CT data with fully continuous-time parameter formulation, including the bolus arrival time. The bolus arrival time for the 2CX and AATH models was described by modifying the vascular transport operator theory. Initial results indicate that single-input tracer kinetic modeling is feasible for distinguishing between hepatocellular carcinoma and normal liver parenchyma.

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肝脏四期动态增强CT连续时间形式单输入示踪动力学建模的可行性。

使用低时间分辨率数据的示踪动力学建模对于动态对比增强CT (DCE-CT)研究中患者剂量减少至关重要。肝脏的示踪动力学模型根据施加在模型上的生理假设而变化，它们在血液供应输入和组织室的建模方式上可能有很大的不同。本研究采用单输入限流(FL)、Tofts-Kety (TK)、扩展TK (ETK)、Hayton-Brady (HB)、两室交换(2CX)和组织均匀性绝热近似(AATH)模型分析肝脏4期DCE-CT数据，并采用全连续时间参数公式，包括丸到达时间。通过修正血管运输算子理论，描述了2CX和AATH模型的药物到达时间。初步结果表明，单输入示踪动力学模型可用于区分肝细胞癌和正常肝实质。

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Abdominal imaging : computational and clinical applications : 6th International Workshop, ABDI 2014, held in conjunction with MICCAI 2014, Cambridge, MA, USA, September 14, 2014. ABDI (Workshop) (6th : 2014 : Cambridge, Mass.)

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