Information-Preserving Pseudo-Enhancement Correction for Non-Cathartic Low-Dose Dual-Energy CT Colonography.

Janne J Näppi, Rie Tachibana, Daniele Regge, Hiroyuki Yoshida
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引用次数: 2

Abstract

In CT colonography (CTC), orally administered positive-contrast fecal-tagging agents can cause artificial elevation of the observed radiodensity of adjacent soft tissue. Such pseudo-enhancement makes it challenging to differentiate polyps and folds reliably from tagged materials, and it is also present in dual-energy CTC (DE-CTC). We developed a method that corrects for pseudo-enhancement on DE-CTC images without distorting the dual-energy information contained in the data. A pilot study was performed to evaluate the effect of the method visually and quantitatively by use of clinical non-cathartic low-dose DE-CTC data from 10 patients including 13 polyps covered partially or completely by iodine-based fecal tagging. The results indicate that the proposed method can be used to reduce the pseudo-enhancement distortion of DE-CTC images without losing material-specific dual-energy information. The method has potential application in improving the accuracy of automated image-processing applications, such as computer-aided detection and virtual bowel cleansing in CTC.

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非泻性低剂量双能CT结肠镜检查的保信息伪增强校正。
在CT结肠镜检查(CTC)中,口服阳性对比粪便标记剂可引起观察到的邻近软组织放射密度的人为升高。这种伪增强使得从标记材料中可靠地区分息肉和褶皱具有挑战性,并且也存在于双能CTC (DE-CTC)中。我们开发了一种校正DE-CTC图像伪增强而不扭曲数据中包含的双能量信息的方法。通过使用10例患者的临床非泻性低剂量DE-CTC数据,其中包括13例部分或完全被基于碘的粪便标记覆盖的息肉,进行了一项初步研究,以直观和定量地评估该方法的效果。结果表明,该方法可以在不丢失材料特异性双能信息的情况下降低DE-CTC图像的伪增强失真。该方法在提高自动图像处理应用的准确性方面具有潜在的应用前景,例如计算机辅助检测和CTC的虚拟肠道清洁。
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Feasibility of Single-Input Tracer Kinetic Modeling with Continuous-Time Formalism in Liver 4-Phase Dynamic Contrast-Enhanced CT. Information-Preserving Pseudo-Enhancement Correction for Non-Cathartic Low-Dose Dual-Energy CT Colonography. Application of Pseudo-enhancement Correction to Virtual Monochromatic CT Colonography.
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