Myxoid Liposarcoma: Prognostic Factors and Metastatic Pattern in a Series of 148 Patients Treated at a Single Institution.

IF 1.6 Q4 ONCOLOGY International Journal of Surgical Oncology Pub Date : 2018-05-16 eCollection Date: 2018-01-01 DOI:10.1155/2018/8928706
Francesco Muratori, Leonardo Bettini, Filippo Frenos, Nicola Mondanelli, Daniela Greto, Lorenzo Livi, Alessandro Franchi, Giuliana Roselli, Maurizio Scorianz, Rodolfo Capanna, Domenico Campanacci
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Abstract

Objectives: The authors reported a retrospective study on myxoid liposarcomas (MLs), evaluating factors that may influence overall survival (OS), local recurrence-free survival (LRFS), metastasis-free survival (MFS), and analyzing the metastatic pattern.

Methods: 148 MLs were analyzed. The sites of metastases were investigated.

Results: Margins (p = 0.002), grading (p = 0,0479), and metastasis (p < 0,0001) were significant risk factors affecting overall survival (OS). Type of presentation (p = 0.0243), grading (p = 0,0055), margin (p = 0.0001), and local recurrence (0.0437) were risk factors on metastasis-free survival (MFS). Authors did not observe statistically significant risk factors for local recurrence-free survival (LRFS) and reported 55% extrapulmonary metastases and 45% pulmonary metastases.

Conclusion: Margins, grading, presentation, local recurrence, and metastasis were prognostic factors. Extrapulmonary metastases were more frequent in myxoid liposarcoma.

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肌样脂肪肉瘤:一个机构治疗的 148 例患者的预后因素和转移模式。
研究目的作者报告了一项关于肌样脂肪肉瘤(MLs)的回顾性研究,评估了可能影响总生存期(OS)、无局部复发生存期(LRFS)、无转移生存期(MFS)的因素,并分析了转移模式。方法:对 148 例 ML 进行分析,调查转移部位:边缘(p = 0.002)、分级(p = 0.0479)和转移(p < 0.0001)是影响总生存期(OS)的重要风险因素。发病类型(p = 0.0243)、分级(p = 0.0055)、边缘(p = 0.0001)和局部复发(0.0437)是影响无转移生存期(MFS)的风险因素。作者没有观察到对无局部复发生存期(LRFS)有统计学意义的风险因素,并报告了55%的肺外转移和45%的肺转移:结论:边缘、分级、表现、局部复发和转移是预后因素。肺外转移在肌样脂肪肉瘤中更为常见。
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来源期刊
CiteScore
3.70
自引率
0.00%
发文量
5
审稿时长
20 weeks
期刊介绍: International Journal of Surgical Oncology is a peer-reviewed, Open Access journal that publishes original research articles, review articles, and clinical studies in all areas of surgical oncology.
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