The Effect of Repetitive Transcranial Magnetic Stimulation on the Reinstatement of Methamphetamine-Induced Conditioned Place Preference in Rats.

上海精神医学 Pub Date : 2018-06-25 DOI:10.11919/j.issn.1002-0829.218007

Xueqing Wu, Yunyue Ju, Dongliang Jiao, Min Zhao

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引用次数: 7

Abstract

Background: The abuse of methamphetamine (METH) has become a public health problem worldwide. This type of new drug can not only lead to addiction but can also cause cognitive impairment. Currently, there is no effective treatment. Repetitive transcranial magnetic stimulation (rTMS) is a painless and non-invasive green physiotherapy which can be used in the clinical treatment of neuropsychiatric disorders such as depression, anxiety, schizophrenia, and Parkinson's disease. However, whether it can be used to treat methamphetamine addiction is unclear.

Objective: To explore the effect of rTMS on the relapse behavior of methamphetamine addiction.

Methods: METH-induced rats conditioned place preference (CPP) model and rTMS technique were used in this study. Rats were given high frequency(10Hz) rTMS treatment for one day (experiment 1) or three days (experiment 2) after the extinction of CPP behavior. The reinstatement test was performed 24 hours after rTMS treatment and the effects of acute and chronic rTMS on the reinstatement of METH-induced CPP in rats were explored.

Results: Acute rTMS treatment (1 day) had a trend of an inhibitory effect on the relapse behavior of METH-induced CPP, but it was not statistically significant compared with the sham stimulation group (t=1.48, p=0.431). However, chronic rTMS treatment (3 days) had a significant inhibitory effect on the reinstatement of METH-induced CPP compared with the sham stimulation group (t=3.33, p=0.004).

Conclusion: Chronic rTMS treatment inhibited the relapse behavior of METH-induced CPP in rats.

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反复经颅磁刺激对大鼠甲基苯丙胺诱导的条件性位置偏好恢复的影响。

背景:甲基苯丙胺(冰毒)的滥用已成为一个全球性的公共卫生问题。这种新药不仅会使人上瘾，还会引起认知障碍。目前尚无有效的治疗方法。重复经颅磁刺激(rTMS)是一种无痛、无创的绿色物理疗法，可用于临床治疗抑郁症、焦虑症、精神分裂症、帕金森病等神经精神疾病。然而，它是否可以用于治疗甲基苯丙胺成瘾尚不清楚。目的:探讨rTMS对甲基苯丙胺成瘾者复吸行为的影响。方法:采用冰毒诱导大鼠条件性位置偏好(CPP)模型和rTMS技术。大鼠在CPP行为消失后给予高频(10Hz) rTMS治疗1天(实验1)或3天(实验2)。在rTMS治疗24 h后进行恢复试验，探讨急性和慢性rTMS对冰毒诱导大鼠CPP恢复的影响。结果:急性rTMS治疗(1 d)对meth诱导的CPP复发行为有抑制作用的趋势，但与假药刺激组比较无统计学意义(t=1.48, p=0.431)。然而，慢性rTMS治疗(3 d)与假刺激组相比，对meth诱导的CPP恢复有显著的抑制作用(t=3.33, p=0.004)。结论:慢性rTMS治疗可抑制冰毒诱导大鼠CPP的复发行为。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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上海精神医学

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