{"title":"Effect of Xiaoerfeire Kechuan Granule in the treatment of children with bronchopneumonia and its effect on serum APC and IL-1R","authors":"Rong-bo Jia","doi":"10.3760/CMA.J.ISSN.1008-6706.2020.05.006","DOIUrl":null,"url":null,"abstract":"Objective \nTo observe the effect of Xiaoerfeire Kechuan Granule in the treatment of bronchopneumonia in children and its effect on serum activating protein(APC) and interleukin-1 receptor(IL-1R). \n \n \nMethods \nFrom June 2016 to June 2018, 116 children with pediatric bronchial pneumonia admitted to the Maternal and Child Health Hospital of Lishui were selected as observation subjects.According to the random number table method, the patients were divided into observation group and control group, with 58 cases in each group.Both two groups were given conventional therapy.On the basis of this treatment, the observation group was treated with Xiaoerfeire Kechuan Granule.The therapeutic effects, the disappearance time of clinical symptoms, and the changes of APC and IL-1R levels before and after treatment were observed. \n \n \nResults \nAfter treatment, the total effective rate of the observation group was 96.55%, which was higher than that of the control group(81.03%), the difference was statistically significant(χ2=7.017, P=0.008). The defervescence time, lung voice disappeared time, disappearance time of X-ray inflammation and disappearance time of cough in the observation group were shorter than those in the control group, and the differences were statistically significant(t=9.134, 13.157, 3.407, 8.532, all P 0.05). After treatment, the serum ACP levels increased in both two groups(all P<0.05), and the ACP level of the observation group was higher than that of the control group(t=5.209, P<0.05); the serum IL-1R level of the two groups were decreased(all P<0.05), and the IL-1R level of the observation group was lower than that of the control group (t=11.835, P<0.05). \n \n \nConclusion \nXiaoerfeire Kechuan Granule is effective in the treatment of children with bronchopneumonia, which can improve the clinical symptoms of children rapidly, its mechanism may be related to lowering serum IL-1R level and increasing APC level. \n \n \nKey words: \nXiaoerfeire Kechuan Granule; Bronchial pneumonia; Integrated Chinese and western medicine therapy; activating protein; IL-1R; Efficacy; Improve symptoms","PeriodicalId":10226,"journal":{"name":"中国基层医药","volume":"27 1","pages":"537-540"},"PeriodicalIF":0.0000,"publicationDate":"2020-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"中国基层医药","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.3760/CMA.J.ISSN.1008-6706.2020.05.006","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
引用次数: 0
Abstract
Objective
To observe the effect of Xiaoerfeire Kechuan Granule in the treatment of bronchopneumonia in children and its effect on serum activating protein(APC) and interleukin-1 receptor(IL-1R).
Methods
From June 2016 to June 2018, 116 children with pediatric bronchial pneumonia admitted to the Maternal and Child Health Hospital of Lishui were selected as observation subjects.According to the random number table method, the patients were divided into observation group and control group, with 58 cases in each group.Both two groups were given conventional therapy.On the basis of this treatment, the observation group was treated with Xiaoerfeire Kechuan Granule.The therapeutic effects, the disappearance time of clinical symptoms, and the changes of APC and IL-1R levels before and after treatment were observed.
Results
After treatment, the total effective rate of the observation group was 96.55%, which was higher than that of the control group(81.03%), the difference was statistically significant(χ2=7.017, P=0.008). The defervescence time, lung voice disappeared time, disappearance time of X-ray inflammation and disappearance time of cough in the observation group were shorter than those in the control group, and the differences were statistically significant(t=9.134, 13.157, 3.407, 8.532, all P 0.05). After treatment, the serum ACP levels increased in both two groups(all P<0.05), and the ACP level of the observation group was higher than that of the control group(t=5.209, P<0.05); the serum IL-1R level of the two groups were decreased(all P<0.05), and the IL-1R level of the observation group was lower than that of the control group (t=11.835, P<0.05).
Conclusion
Xiaoerfeire Kechuan Granule is effective in the treatment of children with bronchopneumonia, which can improve the clinical symptoms of children rapidly, its mechanism may be related to lowering serum IL-1R level and increasing APC level.
Key words:
Xiaoerfeire Kechuan Granule; Bronchial pneumonia; Integrated Chinese and western medicine therapy; activating protein; IL-1R; Efficacy; Improve symptoms
期刊介绍：
Since its inception, the journal "Chinese Primary Medicine" has adhered to the development strategy of "based in China, serving the grassroots, and facing the world" as its publishing concept, reporting a large amount of the latest medical information at home and abroad, prospering the academic field of primary medicine, and is praised by readers as a medical encyclopedia that updates knowledge. It is a core journal in China's medical and health field, and its influence index (CI) ranks Q2 in China's academic journals in 2022. It was included in the American Chemical Abstracts in 2008, the World Health Organization Western Pacific Regional Medical Index (WPRIM) in 2009, and the Japan Science and Technology Agency Database (JST) and Scopus Database in 2018, and was included in the Wanfang Data-China Digital Journal Group and the China Academic Journal Comprehensive Evaluation Database.
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