Pub Date : 2020-04-01DOI: 10.3760/CMA.J.ISSN.1008-6706.2020.07.003
Ying Zhao
Objective To study the clinical effect of dry chemical method combined with urinary sediment in routine urine examination. Methods From January 2018 to October 2018, 200 patients with suspected urinary tract infection who underwent routine urine examination in the Traditional Chinese Medicine Hospital of Yuyao were selected for prospective study, and fresh morning urine samples were collected from 200 patients.Urine samples were detected by urine dry chemistry analyzer and urine sediment analyzer respectively, and the urine routine indicators of urine dry chemistry method and urine sediment method were compared.According to the results of urine bacterial culture, the sensitivity, specificity and accuracy of urine dry chemical method, urine sediment method and urine dry chemical method for the diagnosis of urinary tract infection were calculated and compared.Then, the consistency test was used to analyze the consistency of results of urine dry chemistry method, urine sediment method, urine dry chemical method+ urine sediment method with urine bacterial culture. Results (1)There were no statistically significant differences between the results of urine dry chemical method and urine sediment method on the urine red blood cell, white blood cell, transparent tube type and other indicators (t=0.562, 0.343, 0.901, all P>0.05). (2)Among 200 suspected patients with urinary tract infection, 157 patients were confirmed to have urinary tract infection by urine bacterial culture, and the remaining 43 patients had no urinary tract infection.The sensitivity, specificity, accuracy of urine dry chemistry method and urine sediment method in the diagnosis of urinary tract infection had no statistically significant differences (χ2=0.120, 0.081, 0.022, all P>0.05). But the sensitivity, specificity, accuracy of urine dry chemistry method + urine sediment method in the diagnosis of urinary tract infection were 96.18%, 97.67%, 96.50%, respectively, which were higher than those of the urine dry chemistry method and urine sediment method (χ2=6.497, 6.081, 11.923, 8.219, 4.962, 12.858, all P<0.05). According to the consistency analysis, the diagnosis results of urinary tract infection by urine dry chemical method and urine sediment method were in good consistency with the results of urine bacterial culture, with the Kappa value of 0.854, while the consistency of urine dry chemical method, urine sediment method with the urine bacterial culture results were all moderate, with the Kappa value of 0.642 and 0.637, respectively. Conclusion The combination of urine dry chemical method and urine sediment method can improve the accuracy of urine routine examination and improve the value of urine routine examination in the diagnosis of urinary tract infection. Key words: Urinary tract infection; Urine routine; Medical examination; Urine dry chemistry; Urine sedimentation method; Diagnosis; Red blood cell; Leukocyte; Hyaline tube type
{"title":"Clinical observation on combined use of dry chemical method and urinary sediment in routine urine examination","authors":"Ying Zhao","doi":"10.3760/CMA.J.ISSN.1008-6706.2020.07.003","DOIUrl":"https://doi.org/10.3760/CMA.J.ISSN.1008-6706.2020.07.003","url":null,"abstract":"Objective \u0000To study the clinical effect of dry chemical method combined with urinary sediment in routine urine examination. \u0000 \u0000 \u0000Methods \u0000From January 2018 to October 2018, 200 patients with suspected urinary tract infection who underwent routine urine examination in the Traditional Chinese Medicine Hospital of Yuyao were selected for prospective study, and fresh morning urine samples were collected from 200 patients.Urine samples were detected by urine dry chemistry analyzer and urine sediment analyzer respectively, and the urine routine indicators of urine dry chemistry method and urine sediment method were compared.According to the results of urine bacterial culture, the sensitivity, specificity and accuracy of urine dry chemical method, urine sediment method and urine dry chemical method for the diagnosis of urinary tract infection were calculated and compared.Then, the consistency test was used to analyze the consistency of results of urine dry chemistry method, urine sediment method, urine dry chemical method+ urine sediment method with urine bacterial culture. \u0000 \u0000 \u0000Results \u0000(1)There were no statistically significant differences between the results of urine dry chemical method and urine sediment method on the urine red blood cell, white blood cell, transparent tube type and other indicators (t=0.562, 0.343, 0.901, all P>0.05). (2)Among 200 suspected patients with urinary tract infection, 157 patients were confirmed to have urinary tract infection by urine bacterial culture, and the remaining 43 patients had no urinary tract infection.The sensitivity, specificity, accuracy of urine dry chemistry method and urine sediment method in the diagnosis of urinary tract infection had no statistically significant differences (χ2=0.120, 0.081, 0.022, all P>0.05). But the sensitivity, specificity, accuracy of urine dry chemistry method + urine sediment method in the diagnosis of urinary tract infection were 96.18%, 97.67%, 96.50%, respectively, which were higher than those of the urine dry chemistry method and urine sediment method (χ2=6.497, 6.081, 11.923, 8.219, 4.962, 12.858, all P<0.05). According to the consistency analysis, the diagnosis results of urinary tract infection by urine dry chemical method and urine sediment method were in good consistency with the results of urine bacterial culture, with the Kappa value of 0.854, while the consistency of urine dry chemical method, urine sediment method with the urine bacterial culture results were all moderate, with the Kappa value of 0.642 and 0.637, respectively. \u0000 \u0000 \u0000Conclusion \u0000The combination of urine dry chemical method and urine sediment method can improve the accuracy of urine routine examination and improve the value of urine routine examination in the diagnosis of urinary tract infection. \u0000 \u0000 \u0000Key words: \u0000Urinary tract infection; Urine routine; Medical examination; Urine dry chemistry; Urine sedimentation method; Diagnosis; Red blood cell; Leukocyte; Hyaline tube type","PeriodicalId":10226,"journal":{"name":"Chinese Journal of Primary Medicine and Pharmacy","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2020-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"49408783","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2020-04-01DOI: 10.3760/CMA.J.ISSN.1008-6706.2020.07.015
Lifang Min, Lan Yu, Jun Yang, Jun Chen
Objective To investigate the effect, safety and compliance of micro-implant anchorage in adolescent orthodontic treatment. Methods A total of 50 adolescent patients who underwent orthodontic treatment from March 2017 to March 2019 in the Department of Stomatology, Li Huili Hospital of Ningbo Medical Center were selected and randomly divided into control group and observation group according to the digital table, with 25 cases in each group.The control group received conventional corrective treatment, and the observation group received micro-implant anchorage therapy.The treatment efficacy, upper incisor dip angle and tooth convexity difference, molar displacement, safety, adverse reactions and compliance were compared between the two groups. Results There were no statistically significant differences in gender, age, etc.between the two groups(all P>0.05). The improvement of the incisor angle difference, tooth crown distance difference and molar displacement difference in the observation group were significantly better than those in the control group, the differences were statistically significant(t=11.328, 20.011, 17.336, all P<0.05). The incidence of adverse reactions such as soft tissue edema, oral inflammation and discomfort of correction in the observation group (8%) was lower than that in the control group(28%), the difference was statistically significant(χ2=10.225, P<0.05). The compliance of patients in the observation group (96%) was significantly higher than that in the control group (80%), the difference was statistically significant(χ2=19.316, P<0.05). Conclusion The micro-implant anchorage is effective in the clinical treatment of adolescent orthodontics, with high safety and high patients’ compliance.It is worthy of clinical promotion. Key words: Micro-implant monoclonal antibody; Orthodontics; Adolescent; Oral function; Adverse reaction; Curative effect; Safety; Compliance
{"title":"The effect, safety and compliance of micro-implant anchorage in adolescent orthodontic treatment","authors":"Lifang Min, Lan Yu, Jun Yang, Jun Chen","doi":"10.3760/CMA.J.ISSN.1008-6706.2020.07.015","DOIUrl":"https://doi.org/10.3760/CMA.J.ISSN.1008-6706.2020.07.015","url":null,"abstract":"Objective \u0000To investigate the effect, safety and compliance of micro-implant anchorage in adolescent orthodontic treatment. \u0000 \u0000 \u0000Methods \u0000A total of 50 adolescent patients who underwent orthodontic treatment from March 2017 to March 2019 in the Department of Stomatology, Li Huili Hospital of Ningbo Medical Center were selected and randomly divided into control group and observation group according to the digital table, with 25 cases in each group.The control group received conventional corrective treatment, and the observation group received micro-implant anchorage therapy.The treatment efficacy, upper incisor dip angle and tooth convexity difference, molar displacement, safety, adverse reactions and compliance were compared between the two groups. \u0000 \u0000 \u0000Results \u0000There were no statistically significant differences in gender, age, etc.between the two groups(all P>0.05). The improvement of the incisor angle difference, tooth crown distance difference and molar displacement difference in the observation group were significantly better than those in the control group, the differences were statistically significant(t=11.328, 20.011, 17.336, all P<0.05). The incidence of adverse reactions such as soft tissue edema, oral inflammation and discomfort of correction in the observation group (8%) was lower than that in the control group(28%), the difference was statistically significant(χ2=10.225, P<0.05). The compliance of patients in the observation group (96%) was significantly higher than that in the control group (80%), the difference was statistically significant(χ2=19.316, P<0.05). \u0000 \u0000 \u0000Conclusion \u0000The micro-implant anchorage is effective in the clinical treatment of adolescent orthodontics, with high safety and high patients’ compliance.It is worthy of clinical promotion. \u0000 \u0000 \u0000Key words: \u0000Micro-implant monoclonal antibody; Orthodontics; Adolescent; Oral function; Adverse reaction; Curative effect; Safety; Compliance","PeriodicalId":10226,"journal":{"name":"Chinese Journal of Primary Medicine and Pharmacy","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2020-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"46316349","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2020-04-01DOI: 10.3760/CMA.J.ISSN.1008-6706.2020.07.008
Haiming Chen, D. Dong, Xian-Dong Wang
Objective To investigate the serum level of miR-126 in patients with hypertensive intracerebral hemorrhage and to elucidate its clinical significance in hypertensive cerebral hemorrhage. Methods From January 2015 to December 2018, 60 patients with hypertensive cerebral hemorrhage were selected as observation group, and 60 healthy subjects were selected as control group in the People's Hospital of Lin'an Affiliated to Hangzhou Medical College.The serum levels of miR-126 were determined by reverse transcription-polymerase chain reaction (RT-PCR). The serum levels of C-reactive protein (CRP), tumor necrosis factor-ɑ (TNF-ɑ) and nuclear factor kappa B (NF-κB) were measured by enzyme-linked immunosorbent assay (ELISA). Results The serum level of miR-126 in the observation group was lower than that in the control group [(0.46±0.11) vs.(1.00±0.13), t=24.562, P<0.05], and the serum levels of CRP, TNF-ɑ and NF-κB were higher than those in the control group[(8.74±0.69)mg/L vs.(3.98±0.61)mg/L, (62.43±8.26)μg/L vs.(31.28±6.54)μg/L, (19.73±1.02)μmol/L vs.(4.92±0.87)μmol/L, t=40.034, 22.902, 85.570, all P<0.05]. There were statistically significant differences in serum miR-126, CRP, TNF-ɑ, NF-κB levels among patients with different severity of hypertensive intracerebral hemorrhage[(0.57±0.09) vs.(0.44±0.12) vs.(0.36±0.11), (6.91±0.72)mg/L vs.(8.63±0.67)mg/L vs.(9.14±0.75)mg/L, (53.16±8.19)μg/L vs.(62.57±8.33)μg/L vs.(70.38±8.09)μg/L, (12.49±0.97)μmol/L vs.(19.58±1.11)μmol/L vs.(25.64±1.05)μmol/L, F=14.433, 41.379, 17.796, 623.893, all P<0.05], with the severity increased, the serum miR-126 level decreased, serum CRP, TNF-ɑ and NF-κB levels increased.The serum miR-126 level in patients with hypertensive cerebral hemorrhage of the poor prognosis group was lower than that of the good prognosis group [(0.53±0.10) vs.(0.38±0.12), t=5.279, P<0.05], and the serum levels of CRP, TNF-ɑ and NF-κB in the poor prognosis group were higher than those in the good prognosis group[(7.85±0.64)mg/L vs.(9.16±0.73)mg/L, (51.07±8.32)μg/L vs.(73.26±8.17)μg/L, (14.73±1.08)μmol/L vs.(26.52±0.99)μmol/L, t=7.392, 10.317, 43.424, all P<0.05]. The area of brain edema in patients with hypertensive intracerebral hemorrhage was negatively correlated with serum miR-126 (r=-0.623, P<0.05), and positively correlated with serum CRP, TNF-ɑ and NF-κB (r=0.581, 0.618, 0.642, all P<0.05). The serum miR-126 level was negatively correlated with CRP, TNF-ɑ and NF-κB in patients with hypertensive intracerebral hemorrhage (r=-0.593, -0.624, -0.618, all P<0.05). Conclusion The serum level of miR-126 is reduced in patients with hypertensive intracerebral hemorrhage, which may participate in the pathogenesis of hypertensive cerebral hemorrhage by participating in inflammatory reaction.The detection of serum miR-126 level has great value in evaluation of the severity and prognosis of hypertensive cerebral hemorrhage. Key words: Intracranial hemorrhage, hypertensive; MicroRNAs; C-reac
{"title":"Serum level of miR-126 in patients with hypertensive intracerebral hemorrhage and its clinical significance","authors":"Haiming Chen, D. Dong, Xian-Dong Wang","doi":"10.3760/CMA.J.ISSN.1008-6706.2020.07.008","DOIUrl":"https://doi.org/10.3760/CMA.J.ISSN.1008-6706.2020.07.008","url":null,"abstract":"Objective \u0000To investigate the serum level of miR-126 in patients with hypertensive intracerebral hemorrhage and to elucidate its clinical significance in hypertensive cerebral hemorrhage. \u0000 \u0000 \u0000Methods \u0000From January 2015 to December 2018, 60 patients with hypertensive cerebral hemorrhage were selected as observation group, and 60 healthy subjects were selected as control group in the People's Hospital of Lin'an Affiliated to Hangzhou Medical College.The serum levels of miR-126 were determined by reverse transcription-polymerase chain reaction (RT-PCR). The serum levels of C-reactive protein (CRP), tumor necrosis factor-ɑ (TNF-ɑ) and nuclear factor kappa B (NF-κB) were measured by enzyme-linked immunosorbent assay (ELISA). \u0000 \u0000 \u0000Results \u0000The serum level of miR-126 in the observation group was lower than that in the control group [(0.46±0.11) vs.(1.00±0.13), t=24.562, P<0.05], and the serum levels of CRP, TNF-ɑ and NF-κB were higher than those in the control group[(8.74±0.69)mg/L vs.(3.98±0.61)mg/L, (62.43±8.26)μg/L vs.(31.28±6.54)μg/L, (19.73±1.02)μmol/L vs.(4.92±0.87)μmol/L, t=40.034, 22.902, 85.570, all P<0.05]. There were statistically significant differences in serum miR-126, CRP, TNF-ɑ, NF-κB levels among patients with different severity of hypertensive intracerebral hemorrhage[(0.57±0.09) vs.(0.44±0.12) vs.(0.36±0.11), (6.91±0.72)mg/L vs.(8.63±0.67)mg/L vs.(9.14±0.75)mg/L, (53.16±8.19)μg/L vs.(62.57±8.33)μg/L vs.(70.38±8.09)μg/L, (12.49±0.97)μmol/L vs.(19.58±1.11)μmol/L vs.(25.64±1.05)μmol/L, F=14.433, 41.379, 17.796, 623.893, all P<0.05], with the severity increased, the serum miR-126 level decreased, serum CRP, TNF-ɑ and NF-κB levels increased.The serum miR-126 level in patients with hypertensive cerebral hemorrhage of the poor prognosis group was lower than that of the good prognosis group [(0.53±0.10) vs.(0.38±0.12), t=5.279, P<0.05], and the serum levels of CRP, TNF-ɑ and NF-κB in the poor prognosis group were higher than those in the good prognosis group[(7.85±0.64)mg/L vs.(9.16±0.73)mg/L, (51.07±8.32)μg/L vs.(73.26±8.17)μg/L, (14.73±1.08)μmol/L vs.(26.52±0.99)μmol/L, t=7.392, 10.317, 43.424, all P<0.05]. The area of brain edema in patients with hypertensive intracerebral hemorrhage was negatively correlated with serum miR-126 (r=-0.623, P<0.05), and positively correlated with serum CRP, TNF-ɑ and NF-κB (r=0.581, 0.618, 0.642, all P<0.05). The serum miR-126 level was negatively correlated with CRP, TNF-ɑ and NF-κB in patients with hypertensive intracerebral hemorrhage (r=-0.593, -0.624, -0.618, all P<0.05). \u0000 \u0000 \u0000Conclusion \u0000The serum level of miR-126 is reduced in patients with hypertensive intracerebral hemorrhage, which may participate in the pathogenesis of hypertensive cerebral hemorrhage by participating in inflammatory reaction.The detection of serum miR-126 level has great value in evaluation of the severity and prognosis of hypertensive cerebral hemorrhage. \u0000 \u0000 \u0000Key words: \u0000Intracranial hemorrhage, hypertensive; MicroRNAs; C-reac","PeriodicalId":10226,"journal":{"name":"Chinese Journal of Primary Medicine and Pharmacy","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2020-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"70008574","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2020-04-01DOI: 10.3760/CMA.J.ISSN.1008-6706.2020.07.012
Sui Xu, R. Fu, Li-ping Chen, Wenqing Lu, Changhong Yan, Ying-bin Jiang, Lin Li, Qiao-Ling Wang
Objective To evaluate the effect and influence of exchange transfusion on neonatal ABO hemolysis by comparing the changes of indirect bilirubin in serum and internal environment before and after exchange transfusion. Methods A retrospective analysis of 242 cases with neonatal ABO hemolytic disease from January 2017 to October 2018 in the Children's Hospital of Jiangxi Province was carried out.According to whether the parents signed or agreed to exchange transfusion, they were divided into two groups.The exchange group (126 cases) received routine treatment + exchange of blood, and the control group (116 cases) was only given conventional therapy(blue light + probiotics + gamma globulin). In the exchange group, peripheral venous blood was collected half an hour before the exchange of blood(T1) and half an hour after the exchange of blood(T2), while in the control group, the indirect bilirubin, platelet and blood sugar were measured at two time points of parents signing disapproval of exchange of blood(T1) and disapproval of exchange of blood and one day after the treatment(T2). Results The indirect bilirubin levels in serum of the exchange group and the control group were decreased, and the difference was statistically significant[(194.010±41.065)μmol/L vs.(390.048±39.058)μmol/L, t=1507.604, (292.014±39.998)μmol/L vs.(383.452±42.820)μmol/L, t=306.820, all P<0.05]. The decrease of serum indirect bilirubin in the exchange group was more significant than that in the control group, and the difference was statistically significant.[(194.010±41.065)μmol/L vs.(292.014±39.998)μmol/L, t=368.267, P<0.05]. After exchange transfusion, the levels of platelet and blood sugar were decreased significantly, and the differences were statistically significant[(91.370±24.766)×109/L vs.(350.660±32.564)×109/L, t=5061.203, (2.965±0.593)mmol/L vs.(5.490±0.876)mmol/L, t=717.817, all P<0.05]. Decreased platelets and blood sugar could return to normal within 3 days. Conclusion Exchange therapy can significantly reduce the level of bilirubin and the incidence of bilirubin encephalopathy in neonates with ABO hemolysis.Exchange therapy has certain effect on the internal environment of neonatal ABO hemolytic patients, which is easy to cause thrombocytopenia and blood sugar reduction.But the change of internal environment is temporary and reversible. Key words: Neonate; ABO hemolytic disease; Hyperbilirubinemia; Phototherapy; Exchange transfusion; Curative effect; Influence; Bilirubin encephalopathy
{"title":"Application of synchronous arteriovenous exchange in neonatal ABO hemolysis","authors":"Sui Xu, R. Fu, Li-ping Chen, Wenqing Lu, Changhong Yan, Ying-bin Jiang, Lin Li, Qiao-Ling Wang","doi":"10.3760/CMA.J.ISSN.1008-6706.2020.07.012","DOIUrl":"https://doi.org/10.3760/CMA.J.ISSN.1008-6706.2020.07.012","url":null,"abstract":"Objective \u0000To evaluate the effect and influence of exchange transfusion on neonatal ABO hemolysis by comparing the changes of indirect bilirubin in serum and internal environment before and after exchange transfusion. \u0000 \u0000 \u0000Methods \u0000A retrospective analysis of 242 cases with neonatal ABO hemolytic disease from January 2017 to October 2018 in the Children's Hospital of Jiangxi Province was carried out.According to whether the parents signed or agreed to exchange transfusion, they were divided into two groups.The exchange group (126 cases) received routine treatment + exchange of blood, and the control group (116 cases) was only given conventional therapy(blue light + probiotics + gamma globulin). In the exchange group, peripheral venous blood was collected half an hour before the exchange of blood(T1) and half an hour after the exchange of blood(T2), while in the control group, the indirect bilirubin, platelet and blood sugar were measured at two time points of parents signing disapproval of exchange of blood(T1) and disapproval of exchange of blood and one day after the treatment(T2). \u0000 \u0000 \u0000Results \u0000The indirect bilirubin levels in serum of the exchange group and the control group were decreased, and the difference was statistically significant[(194.010±41.065)μmol/L vs.(390.048±39.058)μmol/L, t=1507.604, (292.014±39.998)μmol/L vs.(383.452±42.820)μmol/L, t=306.820, all P<0.05]. The decrease of serum indirect bilirubin in the exchange group was more significant than that in the control group, and the difference was statistically significant.[(194.010±41.065)μmol/L vs.(292.014±39.998)μmol/L, t=368.267, P<0.05]. After exchange transfusion, the levels of platelet and blood sugar were decreased significantly, and the differences were statistically significant[(91.370±24.766)×109/L vs.(350.660±32.564)×109/L, t=5061.203, (2.965±0.593)mmol/L vs.(5.490±0.876)mmol/L, t=717.817, all P<0.05]. Decreased platelets and blood sugar could return to normal within 3 days. \u0000 \u0000 \u0000Conclusion \u0000Exchange therapy can significantly reduce the level of bilirubin and the incidence of bilirubin encephalopathy in neonates with ABO hemolysis.Exchange therapy has certain effect on the internal environment of neonatal ABO hemolytic patients, which is easy to cause thrombocytopenia and blood sugar reduction.But the change of internal environment is temporary and reversible. \u0000 \u0000 \u0000Key words: \u0000Neonate; ABO hemolytic disease; Hyperbilirubinemia; Phototherapy; Exchange transfusion; Curative effect; Influence; Bilirubin encephalopathy","PeriodicalId":10226,"journal":{"name":"Chinese Journal of Primary Medicine and Pharmacy","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2020-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"44918490","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2020-04-01DOI: 10.3760/CMA.J.ISSN.1008-6706.2020.07.019
Long Huang, Guoxing Mao
Objective To investigate the effect of soft channel minimally invasive treatment on hypertensive intracerebral hemorrhage (HICH) and its influence on serum interleukin-18 (IL-18), vascular endothelial growth factor (VEGF), C-reactive protein (CRP) and tumor necrosis factor-α (TNF-α). Methods From April 2017 to April 2019, 82 patients with HICH admitted to Taizhou Hospital of Traditional Chinese Medicine were randomly divided into observation group (41 cases) and control group (41 cases) according to random number table method.The control group was treated with hard channel minimally invasive treatment, while the observation group was treated with soft channel minimally invasive treatment.The therapeutic effect, intracranial hematoma volume, serum levels of IL-18, VEGF, CRP and TNF-α before and 7 days after operation, neurological deficit degree (NIHSS) scores before and 3 months after operation, and complications after operation were compared between the two groups. Results The total effective rate of the observation group (92.68%) was higher than that of the control group (70.73%) (χ2=6.609, P<0.05). The amount of intracranial hematoma in the observation group [(4.03±1.10)mL] was lower than that in the control group [(7.17±1.36)mL] (t=11.495, P<0.05). At 7 d after operation, the serum levels of IL-18[(123.74±10.27)ng/L], VEGF[(113.28±12.10)ng/L], CRP[(17.83±3.20)mg/L] and TNF-α[(0.65±0.12)ng/L] in the observation group were lower than those in the control group [(150.38±13.21)ng/L, (141.63±16.87)ng/L, (29.96±4.53)mg/L and (1.09±0.17)ng/L] (t=11.638, 9.101, 13.831, 5.569, all P<0.05). The NIHSS score of the observation group[(16.53±3.19)points] was lower than that of the control group[(23.43±4.65)points] at 3 months after operation (t=7.824, P<0.05). The incidence of complications in the observation group (12.20%) was lower than that in the control group (34.15%) (χ2=5.549, P<0.05). Conclusion Soft channel minimally invasive treatment for HICH has good effect and can reduce the changes of serum levels of IL-18, VEGF, CRP and TNF-α. Key words: Intracranial hemorrhage, hypertensive; Surgical procedures, minimally invasive; Soft channel minimally invasive; Hard channel minimally invasive; Interleukin-18; Vascular endothelial growth factor; C-reactive protein; Tumor necrosis factor-α
{"title":"Observation of curative effect of soft channel minimally invasive treatment for hypertensive intracerebral hemorrhage and its influence on serum IL-18, VEGF, CRP and TNF-α in patients with hypertensive intracerebral hemorrhage","authors":"Long Huang, Guoxing Mao","doi":"10.3760/CMA.J.ISSN.1008-6706.2020.07.019","DOIUrl":"https://doi.org/10.3760/CMA.J.ISSN.1008-6706.2020.07.019","url":null,"abstract":"Objective \u0000To investigate the effect of soft channel minimally invasive treatment on hypertensive intracerebral hemorrhage (HICH) and its influence on serum interleukin-18 (IL-18), vascular endothelial growth factor (VEGF), C-reactive protein (CRP) and tumor necrosis factor-α (TNF-α). \u0000 \u0000 \u0000Methods \u0000From April 2017 to April 2019, 82 patients with HICH admitted to Taizhou Hospital of Traditional Chinese Medicine were randomly divided into observation group (41 cases) and control group (41 cases) according to random number table method.The control group was treated with hard channel minimally invasive treatment, while the observation group was treated with soft channel minimally invasive treatment.The therapeutic effect, intracranial hematoma volume, serum levels of IL-18, VEGF, CRP and TNF-α before and 7 days after operation, neurological deficit degree (NIHSS) scores before and 3 months after operation, and complications after operation were compared between the two groups. \u0000 \u0000 \u0000Results \u0000The total effective rate of the observation group (92.68%) was higher than that of the control group (70.73%) (χ2=6.609, P<0.05). The amount of intracranial hematoma in the observation group [(4.03±1.10)mL] was lower than that in the control group [(7.17±1.36)mL] (t=11.495, P<0.05). At 7 d after operation, the serum levels of IL-18[(123.74±10.27)ng/L], VEGF[(113.28±12.10)ng/L], CRP[(17.83±3.20)mg/L] and TNF-α[(0.65±0.12)ng/L] in the observation group were lower than those in the control group [(150.38±13.21)ng/L, (141.63±16.87)ng/L, (29.96±4.53)mg/L and (1.09±0.17)ng/L] (t=11.638, 9.101, 13.831, 5.569, all P<0.05). The NIHSS score of the observation group[(16.53±3.19)points] was lower than that of the control group[(23.43±4.65)points] at 3 months after operation (t=7.824, P<0.05). The incidence of complications in the observation group (12.20%) was lower than that in the control group (34.15%) (χ2=5.549, P<0.05). \u0000 \u0000 \u0000Conclusion \u0000Soft channel minimally invasive treatment for HICH has good effect and can reduce the changes of serum levels of IL-18, VEGF, CRP and TNF-α. \u0000 \u0000 \u0000Key words: \u0000Intracranial hemorrhage, hypertensive; Surgical procedures, minimally invasive; Soft channel minimally invasive; Hard channel minimally invasive; Interleukin-18; Vascular endothelial growth factor; C-reactive protein; Tumor necrosis factor-α","PeriodicalId":10226,"journal":{"name":"Chinese Journal of Primary Medicine and Pharmacy","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2020-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"42728886","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2020-04-01DOI: 10.3760/CMA.J.ISSN.1008-6706.2020.07.017
Yi-Hsun Yu, Li Xie
Objective To investigate the independent risk factors of deep venous thrombosis (DVT) in patients with spinal cord injury (SCI) treated with limb blood circulation pump. Methods From January 2016 to December 2018, 300 patients of thoracolumbar spine fractures with SCI were collected in the department of spinal surgery of Shaoxing Central Hospital.The patients received blood circulation pump to prevent DVT after operation, 48 patients with DVT were classified as DVT group, and the remaining 252 patients were classified as non-DVT group.The basic information (sex, age, height, weight, etc.), body mass index (BMI), chronic disease status (diabetes, hypertension, coronary heart disease, etc.), smoking history, combined lower extremity fracture, SCI classification, operation time, intraoperative blood loss were collected.The differences of above indicators between the DVT group and the non-DVT group were analyzed.The factors with statistical differences were substituted into logistic regression analysis to identify independent risk factors for DVT in patients with SCI who were treated with blood circulation pump. Results The proportion of elderly patients (≥60 years old) in the DVT group was higher than that in the non-DVT group (79.17% vs.57.14%, χ2=8.196, P=0.004), and the proportion of obese patients (BMI≥25kg/m2) in the DVT group was higher than that in the non-DVT group(77.08% vs.56.35%, χ2=7.203, P=0.007), the proportion of patients with diabetes in the DVT group was higher than that in the non-DVT group (68.75% vs.10.71%, χ2=84.877, P=0.000), the proportion of smokers in the DVT group was higher than that in the non-DVT group(81.25% vs.49.21%, χ2=16.685, P=0.000), the proportion of patients with lower extremity fractures in the DVT group was higher than that in the non-DVT group (41.67% vs.7.14%, χ2=43.443, P=0.000), and the proportion of patients with complete injury in the DVT group was higher than that in the non-DVT group (45.83% vs.15.08%, χ2=23.834, P=0.000). Logistic regression analysis showed that diabetes, smoking history and lower extremity fractures were independent risk factors for DVT in SCI patients with limb blood circulation pump (Or=1.138, 1.356, 1.548, P=0.003, 0.007, 0.014). Conclusion The independent risk factors for DVT in SCI patients when using blood circulation pump may include diabetes, smoking history and lower extremity fractures. Key words: Spinal cord injury; Thoracolumbar spine fracture; Limb blood circulation pump; Lower extremity deep vein thrombosis; Diabetes mellitus; Smoking history; Lower limb fracture; Independent risk factor
{"title":"Analysis of related factors in deep venous thrombosis of lower extremity when using limb blood circulation pump in patients with spinal cord injury","authors":"Yi-Hsun Yu, Li Xie","doi":"10.3760/CMA.J.ISSN.1008-6706.2020.07.017","DOIUrl":"https://doi.org/10.3760/CMA.J.ISSN.1008-6706.2020.07.017","url":null,"abstract":"Objective \u0000To investigate the independent risk factors of deep venous thrombosis (DVT) in patients with spinal cord injury (SCI) treated with limb blood circulation pump. \u0000 \u0000 \u0000Methods \u0000From January 2016 to December 2018, 300 patients of thoracolumbar spine fractures with SCI were collected in the department of spinal surgery of Shaoxing Central Hospital.The patients received blood circulation pump to prevent DVT after operation, 48 patients with DVT were classified as DVT group, and the remaining 252 patients were classified as non-DVT group.The basic information (sex, age, height, weight, etc.), body mass index (BMI), chronic disease status (diabetes, hypertension, coronary heart disease, etc.), smoking history, combined lower extremity fracture, SCI classification, operation time, intraoperative blood loss were collected.The differences of above indicators between the DVT group and the non-DVT group were analyzed.The factors with statistical differences were substituted into logistic regression analysis to identify independent risk factors for DVT in patients with SCI who were treated with blood circulation pump. \u0000 \u0000 \u0000Results \u0000The proportion of elderly patients (≥60 years old) in the DVT group was higher than that in the non-DVT group (79.17% vs.57.14%, χ2=8.196, P=0.004), and the proportion of obese patients (BMI≥25kg/m2) in the DVT group was higher than that in the non-DVT group(77.08% vs.56.35%, χ2=7.203, P=0.007), the proportion of patients with diabetes in the DVT group was higher than that in the non-DVT group (68.75% vs.10.71%, χ2=84.877, P=0.000), the proportion of smokers in the DVT group was higher than that in the non-DVT group(81.25% vs.49.21%, χ2=16.685, P=0.000), the proportion of patients with lower extremity fractures in the DVT group was higher than that in the non-DVT group (41.67% vs.7.14%, χ2=43.443, P=0.000), and the proportion of patients with complete injury in the DVT group was higher than that in the non-DVT group (45.83% vs.15.08%, χ2=23.834, P=0.000). Logistic regression analysis showed that diabetes, smoking history and lower extremity fractures were independent risk factors for DVT in SCI patients with limb blood circulation pump (Or=1.138, 1.356, 1.548, P=0.003, 0.007, 0.014). \u0000 \u0000 \u0000Conclusion \u0000The independent risk factors for DVT in SCI patients when using blood circulation pump may include diabetes, smoking history and lower extremity fractures. \u0000 \u0000 \u0000Key words: \u0000Spinal cord injury; Thoracolumbar spine fracture; Limb blood circulation pump; Lower extremity deep vein thrombosis; Diabetes mellitus; Smoking history; Lower limb fracture; Independent risk factor","PeriodicalId":10226,"journal":{"name":"Chinese Journal of Primary Medicine and Pharmacy","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2020-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41350769","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2020-04-01DOI: 10.3760/CMA.J.ISSN.1008-6706.2020.07.020
Jianguo Liu, Xiaoli Liu, Jinjun Kang, Xu Zhang
Objective To investigate the clinical efficacy of Yunke(99TC-MDP) combined with strontium 89SrCl2 in the treatment of bone pain in patients with multiple bone metastases. Methods The clinical data of 95 patients with multiple bone metastases admitted to the General Hospital of Datong Coal Group from August 2014 to July 2019 were retrospectively analyzed.According to the different treatment methods, they were divided into three groups: 37 patients in Yunke group were treated with Yunke alone, 29 patients in 89SrCl2 group were treated with 89SrCl2 alone, 29 patients in combination group were treated with Yunke combined with 89SrCl2.All patients were treated for 5 days, with a course of treatment per month.The clinical efficacy, analgesic time and adverse reactions of the three groups were compared. Results After treatment, the pain relief rates of the Yunke group, the 89SrCl2 group and the combination group were 67.6%(25/37), 69.0%(20/29) and 79.3%(23/29), respectively.The pain relief rate of the combined group was higher than that of the Yunke group(χ2=4.25, P<0.05). The effective rate of bone metastases in the combined group was 41.4%(12/29), which was higher than that in the Yunke group[0.0%(0/37)], the 89SrCl2 group[17.2%(5/29)], the differences were statistically significant(χ2=13.09, 10.54, all P<0.01). No serious adverse reactions were found in the three groups. Conclusion Yunke combined with 89SrCl2 is superior to 89SrCl2 alone, and it is safe in the treatment of bone metastases. Key words: Neoplasm metastasis; Metastatic carcinoma of bone; Bone pain; Methylene diphosphate; Strontium chloride; Comparative study
{"title":"Effect of methylene diphosphate combined with strontium chloride in the treatment of bone pain caused by multiple bone metastases","authors":"Jianguo Liu, Xiaoli Liu, Jinjun Kang, Xu Zhang","doi":"10.3760/CMA.J.ISSN.1008-6706.2020.07.020","DOIUrl":"https://doi.org/10.3760/CMA.J.ISSN.1008-6706.2020.07.020","url":null,"abstract":"Objective \u0000To investigate the clinical efficacy of Yunke(99TC-MDP) combined with strontium 89SrCl2 in the treatment of bone pain in patients with multiple bone metastases. \u0000 \u0000 \u0000Methods \u0000The clinical data of 95 patients with multiple bone metastases admitted to the General Hospital of Datong Coal Group from August 2014 to July 2019 were retrospectively analyzed.According to the different treatment methods, they were divided into three groups: 37 patients in Yunke group were treated with Yunke alone, 29 patients in 89SrCl2 group were treated with 89SrCl2 alone, 29 patients in combination group were treated with Yunke combined with 89SrCl2.All patients were treated for 5 days, with a course of treatment per month.The clinical efficacy, analgesic time and adverse reactions of the three groups were compared. \u0000 \u0000 \u0000Results \u0000After treatment, the pain relief rates of the Yunke group, the 89SrCl2 group and the combination group were 67.6%(25/37), 69.0%(20/29) and 79.3%(23/29), respectively.The pain relief rate of the combined group was higher than that of the Yunke group(χ2=4.25, P<0.05). The effective rate of bone metastases in the combined group was 41.4%(12/29), which was higher than that in the Yunke group[0.0%(0/37)], the 89SrCl2 group[17.2%(5/29)], the differences were statistically significant(χ2=13.09, 10.54, all P<0.01). No serious adverse reactions were found in the three groups. \u0000 \u0000 \u0000Conclusion \u0000Yunke combined with 89SrCl2 is superior to 89SrCl2 alone, and it is safe in the treatment of bone metastases. \u0000 \u0000 \u0000Key words: \u0000Neoplasm metastasis; Metastatic carcinoma of bone; Bone pain; Methylene diphosphate; Strontium chloride; Comparative study","PeriodicalId":10226,"journal":{"name":"Chinese Journal of Primary Medicine and Pharmacy","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2020-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"42241941","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Investigation and research on early rehabilitation and knowledge of severe craniocerebral injury","authors":"Meihong Zheng, Xiaoqing Han, Dongping Shu, Zan'en Li, Jing Wang, Yinyan Wang","doi":"10.3760/CMA.J.ISSN.1008-6706.2020.07.029","DOIUrl":"https://doi.org/10.3760/CMA.J.ISSN.1008-6706.2020.07.029","url":null,"abstract":"目的 \u0000调查护士对重型颅脑损伤患者术后早期康复知识、态度、行为现状，为改善重型颅脑损伤术后早期康复护理工作提供参考。 \u0000 \u0000 \u0000方法 \u0000采用便利抽样的方法，选取嵊州市人民医院2019年1－4月神经外科护士150名进行早期康复知识、态度、行为问卷调查，调查问卷为自行设计，包括《一般情况调查表》和《神经外科护士对重型颅脑损伤术后早期康复知信行调查问卷》。 \u0000 \u0000 \u0000结果 \u0000神经外科护士重型颅脑损伤术后早期康复知识得分为(81.65±17.83)分，术后早期康复态度得分为(42.50±7.83)分，术后早期康复行为得分为(74.86±14.39)分；知识得分与态度得分呈正相关(r＝0.396，P＝0.00 3)，知识得分与行为得分呈正相关(r＝0.231，P＝0.002)，态度得分与行为得分呈正相关(r＝0.480，P＝0.005)。 \u0000 \u0000 \u0000结论 \u0000神经外科护士对重型颅脑损伤术后早期康复护理的知识、态度以及行为水平均位于中等偏上，管理者应加强对护士早期康复护理相关理论知识及临床康复技能的培训，有效转变其负性态度，促进其正性行为，进一步提高其重型颅脑损伤术后康复护理质量。","PeriodicalId":10226,"journal":{"name":"Chinese Journal of Primary Medicine and Pharmacy","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2020-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"43285095","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2020-04-01DOI: 10.3760/CMA.J.ISSN.1008-6706.2020.07.004
Yajun Ma, Peng Cheng, Fudi Chu
Objective To investigate the diagnostic value of combined detection of urine α1-microglobulin(α1-mG), N-acetyl-β-D-glucosaminidase (NAG), retinol binding protein (RBP) and β2-microglobulin (β2-mG) for early hypertensive kidney injury. Methods From June 2016 to December 2018, 116 hypertension patients with renal damage (HRD group) and 44 cases with simple hypertension(HBP group) were selected in the Central People′s Hospital of Tengzhou in this study.And 36 cases of healthy people during the same period were selected as the control group.One hundred and sixteen cases of the HRD group were divided into Ⅰ-Ⅱ group (61 cases) and Ⅲ-Ⅴ group (55 cases) according to the classification of chronic kidney disease(CKD). The concentrations of α1-mG, NAG, RBP and β2-mG in urine were detected in patients and healthy people respectively.SPSS 19.0 software was used to perform statistical analysis. Results The concentrations of urine α1-mG, NAG, RBP, β2-mG in the HRD group were (41.77±24.21)mg/L, (22.60±13.24)U/L, (2.86±1.73)mg/L, (1.76±0.95)mg/L, respectively, which in the HBP group were (12.49±8.10)mg/L, (13.45±8.61)U/L, (0.31±0.16)mg/L, (0.38±0.38)mg/L, respectively, which in the control group were (4.37±2.52)mg/L, (6.12±3.57)U/L, (0.29±0.17)mg/L, (0.28±0.15)mg/L, respectively.The concentrations of urine α1-mG, NAG, RBP, β2-mG in the HRD group were significantly higher than those in the HBP group(t=4.07, 4.25, 4.09, 4.03, all P<0.05) and the control group(t=3.15, 4.94, 2.49, 2.61, all P<0.05). The urine levels of α1-mG, NAG, RBP, β2-mG in phase Ⅰ-Ⅱ group were (21.62±13.45)mg/L, (21.96±12.49)U/L, (0.5±0.47)mg/L, (0.93±0.62)mg/L, respectively, which in the phase Ⅲ-Ⅴ group were (64.11±60.12)mg/L, (23.32±14.11)U/L, (5.48±4.77)mg/L, (2.68±2.55)mg/L, respectively.The concentrations of urine α1-mG, NAG, RBP and β2-mG in Ⅰ-Ⅱ group (t=5.08, 4.99, 2.96, 1.66, all P<0.05) and Ⅲ-Ⅴ group (t=3.95, 4.81, 4.33, 3.74, all P<0.05) were significantly higher than those in the control group.The levels of α1-mG, RBP and β2-mG in group Ⅲ-Ⅴ were higher than those in group Ⅰ-Ⅱ(t=5.37, 8.11, 4.52, all P<0.05). The positive detection rates of α1-mG, NAG, RBP, β2-mG and combination test in phase Ⅰ-Ⅱ group were 70.5%, 77.0%, 19.7%, 60.7%, 91.8%, respectively, which in the phase Ⅲ-Ⅴ group were 81.8%, 81.8%, 69.1%, 69.1% and 96.4%, respectively.The positive rate of urine α1-mG, NAG, RBP and β2-mG combination test was significantly higher than that of the single detection (phase Ⅰ-Ⅱ group: χ2=7.71, 3.99, 61.4, 14.65; phase Ⅲ-Ⅴ group: χ2=4.58, 4.58, 12.47, 12.47; all P<0.05). Conclusion Urine α1-mG, NAG, RBP and β2-mG are important biochemical indicators in patients with early hypertensive kidney injury.The combined detection of the four tests has high diagnostic value in the diagnosis of early hypertensive nephropathy. Key words: Hypertension; Urine protein; Early hypertensive kidney injury; α1-microglobulin; N-acetyl-β-D-glucosaminidase; Retinol binding protein; β2-m
{"title":"Diagnostic value of combined detection of four-item urinary protein for early hypertensive kidney injury","authors":"Yajun Ma, Peng Cheng, Fudi Chu","doi":"10.3760/CMA.J.ISSN.1008-6706.2020.07.004","DOIUrl":"https://doi.org/10.3760/CMA.J.ISSN.1008-6706.2020.07.004","url":null,"abstract":"Objective \u0000To investigate the diagnostic value of combined detection of urine α1-microglobulin(α1-mG), N-acetyl-β-D-glucosaminidase (NAG), retinol binding protein (RBP) and β2-microglobulin (β2-mG) for early hypertensive kidney injury. \u0000 \u0000 \u0000Methods \u0000From June 2016 to December 2018, 116 hypertension patients with renal damage (HRD group) and 44 cases with simple hypertension(HBP group) were selected in the Central People′s Hospital of Tengzhou in this study.And 36 cases of healthy people during the same period were selected as the control group.One hundred and sixteen cases of the HRD group were divided into Ⅰ-Ⅱ group (61 cases) and Ⅲ-Ⅴ group (55 cases) according to the classification of chronic kidney disease(CKD). The concentrations of α1-mG, NAG, RBP and β2-mG in urine were detected in patients and healthy people respectively.SPSS 19.0 software was used to perform statistical analysis. \u0000 \u0000 \u0000Results \u0000The concentrations of urine α1-mG, NAG, RBP, β2-mG in the HRD group were (41.77±24.21)mg/L, (22.60±13.24)U/L, (2.86±1.73)mg/L, (1.76±0.95)mg/L, respectively, which in the HBP group were (12.49±8.10)mg/L, (13.45±8.61)U/L, (0.31±0.16)mg/L, (0.38±0.38)mg/L, respectively, which in the control group were (4.37±2.52)mg/L, (6.12±3.57)U/L, (0.29±0.17)mg/L, (0.28±0.15)mg/L, respectively.The concentrations of urine α1-mG, NAG, RBP, β2-mG in the HRD group were significantly higher than those in the HBP group(t=4.07, 4.25, 4.09, 4.03, all P<0.05) and the control group(t=3.15, 4.94, 2.49, 2.61, all P<0.05). The urine levels of α1-mG, NAG, RBP, β2-mG in phase Ⅰ-Ⅱ group were (21.62±13.45)mg/L, (21.96±12.49)U/L, (0.5±0.47)mg/L, (0.93±0.62)mg/L, respectively, which in the phase Ⅲ-Ⅴ group were (64.11±60.12)mg/L, (23.32±14.11)U/L, (5.48±4.77)mg/L, (2.68±2.55)mg/L, respectively.The concentrations of urine α1-mG, NAG, RBP and β2-mG in Ⅰ-Ⅱ group (t=5.08, 4.99, 2.96, 1.66, all P<0.05) and Ⅲ-Ⅴ group (t=3.95, 4.81, 4.33, 3.74, all P<0.05) were significantly higher than those in the control group.The levels of α1-mG, RBP and β2-mG in group Ⅲ-Ⅴ were higher than those in group Ⅰ-Ⅱ(t=5.37, 8.11, 4.52, all P<0.05). The positive detection rates of α1-mG, NAG, RBP, β2-mG and combination test in phase Ⅰ-Ⅱ group were 70.5%, 77.0%, 19.7%, 60.7%, 91.8%, respectively, which in the phase Ⅲ-Ⅴ group were 81.8%, 81.8%, 69.1%, 69.1% and 96.4%, respectively.The positive rate of urine α1-mG, NAG, RBP and β2-mG combination test was significantly higher than that of the single detection (phase Ⅰ-Ⅱ group: χ2=7.71, 3.99, 61.4, 14.65; phase Ⅲ-Ⅴ group: χ2=4.58, 4.58, 12.47, 12.47; all P<0.05). \u0000 \u0000 \u0000Conclusion \u0000Urine α1-mG, NAG, RBP and β2-mG are important biochemical indicators in patients with early hypertensive kidney injury.The combined detection of the four tests has high diagnostic value in the diagnosis of early hypertensive nephropathy. \u0000 \u0000 \u0000Key words: \u0000Hypertension; Urine protein; Early hypertensive kidney injury; α1-microglobulin; N-acetyl-β-D-glucosaminidase; Retinol binding protein; β2-m","PeriodicalId":10226,"journal":{"name":"Chinese Journal of Primary Medicine and Pharmacy","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2020-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"46360999","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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