Comparison of clinical efficacy of dydrogesterone and progesterone in the treatment of threatened abortion

中国基层医药 Pub Date : 2020-03-15 DOI:10.3760/CMA.J.ISSN.1008-6706.2020.06.008

Shasha Ying, Man-man Zhang

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引用次数: 1

Abstract

Objective To compare the clinical effect of dydrogesterone and progesterone in the treatment of threatened abortion. Methods From March 2015 to May 2017, 50 patients with threatened abortion admitted in the Maternal and Child Health Hospital of Ninghai County were selected and randomly divided into two groups according to the digital table, with 25 cases in each group.The control group was treated with progesterone.The observation group was treated with dydrogesterone.The hormone levels, symptom disappearance time, fetal retention and adverse drug reactions were compared between the two groups. Results One week after treatment, the levels of progesterone, estradiol and human chorionic gonadotropin in the observation group were (1 12.65±6.35)nmol/L, (2 137.99±371.22)pmol/L, (4 261.54±245.55)IU/L, respectively, which in the control group were (101.56±5.32)nmol/L, (1 782.12±350.71)pmol/L, (3 642.26±210.20)IU/L, respectively, the differences between the two groups were statistically significant (t=6.694, 3.484, 9.581, all P 0.05). Conclusion The effect of dydrogesterone in the treatment of threatened abortion is better than progesterone. Key words: Abortion, threatened; Progesterone; Dydrogesterone; Receptors, progesterone; Estradiol; Chorionic gonadotropin; Drug therapy; Comparative study

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地屈孕酮与孕酮治疗先兆流产的临床疗效比较

目的比较孕甾酮和黄体酮治疗先兆流产的临床疗效。方法选择宁海县妇幼保健院2015年3月至2017年5月收治的50例先兆流产患者，按数字表随机分为两组，每组25例。对照组用黄体酮治疗。观察组采用孕甾酮治疗。比较两组的激素水平、症状消失时间、胎儿滞留和药物不良反应。结果治疗1周后，观察组孕酮、雌二醇和人绒毛膜促性腺激素水平分别为（1 12.65±6.35）nmol/L、（2 137.99±371.22）pmol/L、（4 261.54±245.55）IU/L，对照组分别为（101.56±5.32）nmol/L、（1 782.12±350.71）pmol/L、（3 642.26±210.20）IU/L，两组比较差异有统计学意义（t=6.694，3.484，9.581，均P＜0.05）。关键词：堕胎，受到威胁；孕酮；Dydrogesterone；受体，黄体酮；雌二醇；绒毛膜促性腺激素；药物治疗；比较研究

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来源期刊

中国基层医药

CiteScore

0.10

自引率

0.00%

发文量

32251

期刊介绍： Since its inception, the journal "Chinese Primary Medicine" has adhered to the development strategy of "based in China, serving the grassroots, and facing the world" as its publishing concept, reporting a large amount of the latest medical information at home and abroad, prospering the academic field of primary medicine, and is praised by readers as a medical encyclopedia that updates knowledge. It is a core journal in China's medical and health field, and its influence index (CI) ranks Q2 in China's academic journals in 2022. It was included in the American Chemical Abstracts in 2008, the World Health Organization Western Pacific Regional Medical Index (WPRIM) in 2009, and the Japan Science and Technology Agency Database (JST) and Scopus Database in 2018, and was included in the Wanfang Data-China Digital Journal Group and the China Academic Journal Comprehensive Evaluation Database.