{"title":"Therapeutic effect of acitretin combined with traditional Chinese Medicine on pustular psoriasis","authors":"L. Qin","doi":"10.3760/CMA.J.ISSN.1008-6706.2020.05.013","DOIUrl":null,"url":null,"abstract":"Objective \nTo observe the efficacy of acitretin combined with traditional Chinese medicine in the treatment of pustular psoriasis. \n \n \nMethods \nFrom July 2011 to October 2017, 91 patients with pustular psoriasis admitted to the Second People's Hospital of Changzhi were randomly divided into treatment group(n=31), control group Ⅰ (n=30) and control group Ⅱ(n=30) according to the digital table.The patients in the three groups were treated with acitretin combined with traditional Chinese medicine, oral acitretin and traditional Chinese medicine, respectively.The therapeutic effects, the time required for hypothermia, the time required for the complete disappearance of pustules and the average length of hospitalization were compared among the three groups. \n \n \nResults \nThe total effective rate was 93.55%(29/31) in the treatment group, 70.00%(21/30) in the control group Ⅰ and 73.33%(22/30) in the control group Ⅱ.The total effective rate in the treatment group was significantly higher than that in the two control groups(χ2=5.720, 4.546, all P 0.05). The fever allaying time, completely disappearance time of pustules, average hospital stay in the treatment group were (4.24±0.86)d, (7.38±0.72)d, (23.46±0.61)d, respectively, which in the control group Ⅰ were (7.45±0.92)d, (10.45±0.52)d, (30.01±0.82)d, respectively, which in the control group Ⅱ were (8.56±0.78)d, (11.56±0.35)d, (31.53±0.68)d, respectively, which in the control group Ⅰ were significantly shorter than those in the control group Ⅱ(t=14.083, 19.037, 35.476, all P<0.05), which in the treatment group were significantly lower than those in the control group Ⅰ and the control group Ⅱ(t=20.529, 28.682, 48.826, 5.041, 9.699, 7.816, all P<0.05). \n \n \nConclusion \nAcitretin capsule combined with traditional Chinese medicine is effective in the treatment of pustular psoriasis, which can control body temperature in a short time, shorten the time of disappearance of pustule, relieve the pain of patients, and shorten the time of hospitalization at the same time. \n \n \nKey words: \nPsoriasis; Skin diseases; Avera; Drugs, chinese herbal; Drug therapy, combination; Treatment outcome; Comparative study","PeriodicalId":10226,"journal":{"name":"中国基层医药","volume":null,"pages":null},"PeriodicalIF":0.0000,"publicationDate":"2020-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"中国基层医药","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.3760/CMA.J.ISSN.1008-6706.2020.05.013","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
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Abstract
Objective
To observe the efficacy of acitretin combined with traditional Chinese medicine in the treatment of pustular psoriasis.
Methods
From July 2011 to October 2017, 91 patients with pustular psoriasis admitted to the Second People's Hospital of Changzhi were randomly divided into treatment group(n=31), control group Ⅰ (n=30) and control group Ⅱ(n=30) according to the digital table.The patients in the three groups were treated with acitretin combined with traditional Chinese medicine, oral acitretin and traditional Chinese medicine, respectively.The therapeutic effects, the time required for hypothermia, the time required for the complete disappearance of pustules and the average length of hospitalization were compared among the three groups.
Results
The total effective rate was 93.55%(29/31) in the treatment group, 70.00%(21/30) in the control group Ⅰ and 73.33%(22/30) in the control group Ⅱ.The total effective rate in the treatment group was significantly higher than that in the two control groups(χ2=5.720, 4.546, all P 0.05). The fever allaying time, completely disappearance time of pustules, average hospital stay in the treatment group were (4.24±0.86)d, (7.38±0.72)d, (23.46±0.61)d, respectively, which in the control group Ⅰ were (7.45±0.92)d, (10.45±0.52)d, (30.01±0.82)d, respectively, which in the control group Ⅱ were (8.56±0.78)d, (11.56±0.35)d, (31.53±0.68)d, respectively, which in the control group Ⅰ were significantly shorter than those in the control group Ⅱ(t=14.083, 19.037, 35.476, all P<0.05), which in the treatment group were significantly lower than those in the control group Ⅰ and the control group Ⅱ(t=20.529, 28.682, 48.826, 5.041, 9.699, 7.816, all P<0.05).
Conclusion
Acitretin capsule combined with traditional Chinese medicine is effective in the treatment of pustular psoriasis, which can control body temperature in a short time, shorten the time of disappearance of pustule, relieve the pain of patients, and shorten the time of hospitalization at the same time.
Key words:
Psoriasis; Skin diseases; Avera; Drugs, chinese herbal; Drug therapy, combination; Treatment outcome; Comparative study
期刊介绍：
Since its inception, the journal "Chinese Primary Medicine" has adhered to the development strategy of "based in China, serving the grassroots, and facing the world" as its publishing concept, reporting a large amount of the latest medical information at home and abroad, prospering the academic field of primary medicine, and is praised by readers as a medical encyclopedia that updates knowledge. It is a core journal in China's medical and health field, and its influence index (CI) ranks Q2 in China's academic journals in 2022. It was included in the American Chemical Abstracts in 2008, the World Health Organization Western Pacific Regional Medical Index (WPRIM) in 2009, and the Japan Science and Technology Agency Database (JST) and Scopus Database in 2018, and was included in the Wanfang Data-China Digital Journal Group and the China Academic Journal Comprehensive Evaluation Database.
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