Effects of paroxetine hydrochloride combined with buspirone on HAMD and serum BDNF and 5-HT levels in patients with depression

中国临床实用医学 Pub Date : 2017-12-25 DOI:10.3760/CMA.J.ISSN.1673-8799.2017.06.010

Bucong Ren, Hongyan Wang

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Abstract

Objective To investigate the effect of paroxetine hydrochloride combined with buspirone in patients with depression. Methods A retrospective study was performed on 74 cases of patients with depression who were admitted from March 2014 to June 2016.Patients were randomly divided into the normal group and the observation group, with 37 cases in each group.Patients in the normal group were given treatment of paroxetine hydrochloride, the others in the observation group were given treatment of paroxetine hydrochloride combined with buspirone, and both groups were treated for 2 months.The scores of depression(HAMD)were compared between the two groups at admission, 1 month and 2 months after treatment.After the end of treatment, the clinical efficacy of the two groups was compared, the changes of serum BDNF and 5-HT levels, the occurrence of adverse reactions and the life quality were observed at the time of admission and after treatment. Results After 1 month and 2 months, the scores of HAMD were lower than those before treatment, the HAMD score in the observation group was lower than that in the normal group(P 0.05); There was no statistically significant difference in physical role, emotional function, social function, energy, general health, mental health, physical pain and body function between the two groups(P>0.05); after 2 months of treatment, patients of the observation group were superior to those of the normal group in physical role, emotional function, social function, energy, general health, mental health, physical pain and body function(P<0.05). Conclusion Buspirone combined with paroxetine hydrochloride has a significant effect on patients with depression, which can effectively alleviate the degree of depression in patients with increasing serum BDNF and 5-HT content, improve the treatment effect and life quality without increasing the risk of adverse reactions. Key words: Paroxetine hydrochloride; Buspirone; Depression; HAMD score; Serum factor

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盐酸帕罗西汀联合丁螺环酮对抑郁症患者HAMD及血清BDNF、5-羟色胺水平的影响

目的探讨盐酸帕罗西汀联合丁螺环酮治疗抑郁症的疗效。方法对2014年3月至2016年6月收治的74例抑郁症患者进行回顾性研究，将患者随机分为正常组和观察组，每组37例。正常组给予盐酸帕罗西汀治疗，观察组给予盐酸氟西汀联合丁螺环酮治疗，两组均治疗2个月。比较两组患者入院时、治疗后1个月和2个月的抑郁（HAMD）评分。治疗结束后，比较两组的临床疗效，观察入院时和治疗后血清BDNF和5-HT水平的变化、不良反应的发生情况和生活质量。结果1个月和2个月后，HAMD评分均低于治疗前，观察组HAMD评分低于正常组（P＜0.05）；两组在生理角色、情绪功能、社会功能、能量、总体健康、心理健康、身体疼痛和身体功能方面差异无统计学意义（P>0.05）；治疗2个月后，观察组患者在身体角色、情绪功能、社会功能、能量、总体健康、心理健康、身体疼痛和身体功能等方面均优于对照组（P<0.05），在不增加不良反应风险的情况下，能有效缓解血清BDNF和5-HT含量升高患者的抑郁程度，提高治疗效果和生活质量。关键词：盐酸帕罗西汀；丁螺环酮；抑郁症；HAMD得分；血清因子

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中国临床实用医学

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