Pub Date : 2017-12-25DOI: 10.3760/CMA.J.ISSN.1673-8799.2017.06.010
Bucong Ren, Hongyan Wang
Objective To investigate the effect of paroxetine hydrochloride combined with buspirone in patients with depression. Methods A retrospective study was performed on 74 cases of patients with depression who were admitted from March 2014 to June 2016.Patients were randomly divided into the normal group and the observation group, with 37 cases in each group.Patients in the normal group were given treatment of paroxetine hydrochloride, the others in the observation group were given treatment of paroxetine hydrochloride combined with buspirone, and both groups were treated for 2 months.The scores of depression(HAMD)were compared between the two groups at admission, 1 month and 2 months after treatment.After the end of treatment, the clinical efficacy of the two groups was compared, the changes of serum BDNF and 5-HT levels, the occurrence of adverse reactions and the life quality were observed at the time of admission and after treatment. Results After 1 month and 2 months, the scores of HAMD were lower than those before treatment, the HAMD score in the observation group was lower than that in the normal group(P 0.05); There was no statistically significant difference in physical role, emotional function, social function, energy, general health, mental health, physical pain and body function between the two groups(P>0.05); after 2 months of treatment, patients of the observation group were superior to those of the normal group in physical role, emotional function, social function, energy, general health, mental health, physical pain and body function(P<0.05). Conclusion Buspirone combined with paroxetine hydrochloride has a significant effect on patients with depression, which can effectively alleviate the degree of depression in patients with increasing serum BDNF and 5-HT content, improve the treatment effect and life quality without increasing the risk of adverse reactions. Key words: Paroxetine hydrochloride; Buspirone; Depression; HAMD score; Serum factor
{"title":"Effects of paroxetine hydrochloride combined with buspirone on HAMD and serum BDNF and 5-HT levels in patients with depression","authors":"Bucong Ren, Hongyan Wang","doi":"10.3760/CMA.J.ISSN.1673-8799.2017.06.010","DOIUrl":"https://doi.org/10.3760/CMA.J.ISSN.1673-8799.2017.06.010","url":null,"abstract":"Objective \u0000To investigate the effect of paroxetine hydrochloride combined with buspirone in patients with depression. \u0000 \u0000 \u0000Methods \u0000A retrospective study was performed on 74 cases of patients with depression who were admitted from March 2014 to June 2016.Patients were randomly divided into the normal group and the observation group, with 37 cases in each group.Patients in the normal group were given treatment of paroxetine hydrochloride, the others in the observation group were given treatment of paroxetine hydrochloride combined with buspirone, and both groups were treated for 2 months.The scores of depression(HAMD)were compared between the two groups at admission, 1 month and 2 months after treatment.After the end of treatment, the clinical efficacy of the two groups was compared, the changes of serum BDNF and 5-HT levels, the occurrence of adverse reactions and the life quality were observed at the time of admission and after treatment. \u0000 \u0000 \u0000Results \u0000After 1 month and 2 months, the scores of HAMD were lower than those before treatment, the HAMD score in the observation group was lower than that in the normal group(P 0.05); There was no statistically significant difference in physical role, emotional function, social function, energy, general health, mental health, physical pain and body function between the two groups(P>0.05); after 2 months of treatment, patients of the observation group were superior to those of the normal group in physical role, emotional function, social function, energy, general health, mental health, physical pain and body function(P<0.05). \u0000 \u0000 \u0000Conclusion \u0000Buspirone combined with paroxetine hydrochloride has a significant effect on patients with depression, which can effectively alleviate the degree of depression in patients with increasing serum BDNF and 5-HT content, improve the treatment effect and life quality without increasing the risk of adverse reactions. \u0000 \u0000 \u0000Key words: \u0000Paroxetine hydrochloride; Buspirone; Depression; HAMD score; Serum factor","PeriodicalId":64135,"journal":{"name":"中国临床实用医学","volume":"8 1","pages":"37-41"},"PeriodicalIF":0.0,"publicationDate":"2017-12-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"44938961","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2017-12-25DOI: 10.3760/CMA.J.ISSN.1673-8799.2017.06.027
Lili Tan
Objective To investigate the mechanism of glucose transport by recombinant human brain natriuretic peptide(rh-BNP) pretreating myocardial cells in rats with hypoxia/reoxygenation. Methods Left ventricular cardiomyocytes were obtained from SD rats aged 6~8 weeks and were cultured in vitro.They were divided randomly into 5 groups including the control group, hypoxia group, hypoxia/reoxygenation group, rh-BNP pretreating hypoxia group and rh-BNP pretreating hypoxia/reoxygenation group.MTT assay was used to detect the changes of cells viability.The levels of lactate dehydrogenase(LDH), glutathione, superoxide dismutase(SOD) and BNP were measured by ELISA.The expression of iNOS, eNOS, GLUT1 and GLUT4 were detected by RT-PCR. Results The rh-BNP intervention significantly increased the viability of hypoxia and hypoxia/reoxygenation treated cardiomyocytes(P<0.05), reduced the levels of LDH, glutathione, SOD and BNP induced by hypoxia and hypoxia/reoxygenation(P<0.05), and increased the mRNA expression of iNOS, eNOS, GLUT1 and GLUT4 in cardiomyocytes(P<0.05). Conclusion The rh-BNP alleviates hypoxia/reoxygenation-induced cardiomyocytes injury by affecting oxidative stress and the expression of GLUT1 and GLUT4. Key words: Recombinant human brain natriuretic peptide; Hypoxia/Reoxygenation; Glucose transporter; Oxidative stress
{"title":"Mechanism study of glucose transport by recombinant human brain natriuretic peptide pretreating myocardial cells in rats with hypoxia/reoxygenation","authors":"Lili Tan","doi":"10.3760/CMA.J.ISSN.1673-8799.2017.06.027","DOIUrl":"https://doi.org/10.3760/CMA.J.ISSN.1673-8799.2017.06.027","url":null,"abstract":"Objective \u0000To investigate the mechanism of glucose transport by recombinant human brain natriuretic peptide(rh-BNP) pretreating myocardial cells in rats with hypoxia/reoxygenation. \u0000 \u0000 \u0000Methods \u0000Left ventricular cardiomyocytes were obtained from SD rats aged 6~8 weeks and were cultured in vitro.They were divided randomly into 5 groups including the control group, hypoxia group, hypoxia/reoxygenation group, rh-BNP pretreating hypoxia group and rh-BNP pretreating hypoxia/reoxygenation group.MTT assay was used to detect the changes of cells viability.The levels of lactate dehydrogenase(LDH), glutathione, superoxide dismutase(SOD) and BNP were measured by ELISA.The expression of iNOS, eNOS, GLUT1 and GLUT4 were detected by RT-PCR. \u0000 \u0000 \u0000Results \u0000The rh-BNP intervention significantly increased the viability of hypoxia and hypoxia/reoxygenation treated cardiomyocytes(P<0.05), reduced the levels of LDH, glutathione, SOD and BNP induced by hypoxia and hypoxia/reoxygenation(P<0.05), and increased the mRNA expression of iNOS, eNOS, GLUT1 and GLUT4 in cardiomyocytes(P<0.05). \u0000 \u0000 \u0000Conclusion \u0000The rh-BNP alleviates hypoxia/reoxygenation-induced cardiomyocytes injury by affecting oxidative stress and the expression of GLUT1 and GLUT4. \u0000 \u0000 \u0000Key words: \u0000Recombinant human brain natriuretic peptide; Hypoxia/Reoxygenation; Glucose transporter; Oxidative stress","PeriodicalId":64135,"journal":{"name":"中国临床实用医学","volume":"8 1","pages":"92-96"},"PeriodicalIF":0.0,"publicationDate":"2017-12-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"49097081","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2017-12-25DOI: 10.3760/CMA.J.ISSN.1673-8799.2017.06.011
Xiao‐Yong Shen
Objective To evaluate and analysis the value of skin endoscopy in the diagnosis of pigmented basal cell carcinoma of the head and face. Methods A retrospective study was performed on 36 cases of patients(male 20 cases, female 16 cases, aged from 34~66 years old)with suspected pigmented basal cell from January to December 2014.The lesions mainly located in the head and neck, all patients received skin lesion endoscopy, and by 2 senior physicians from department of dermatology, according to the pathological characteristics of mirror skin pigmented basal cell carcinoma, independent of disease diagnosis, the pathological lesion diagnosis as the 'gold standard’, compared and studied the consistency of skin biopsy with pathological findings in the diagnosis of head to head facial pigmented basal cell carcinoma, and analyzed the sensitivity and specificity of diagnosis method. Results Among 36 cases of suspected patients, 25 cases of pigmented basal cell carcinoma were confirmed by histopathology; 27 cases of pigmented basal cell carcinoma were confirmed by A physician, the accuracy, misdiagnosis rate, the rate of missed diagnosis, sensitivity, specificity and Youden index were 92.6%, 27.3%, 4.0%, 87.5%, 33.3% and 68.7%, respectively, A physician diagnosed Kappa index was 0.965, P=0.326, and there was no statistically significant difference between the detection rate of basal cell carcinoma by A physician and pathological examination(P>0.05); 28 cases of pigmented basal cell carcinoma were confirmed by B physician, the accuracy, misdiagnosis rate, the rate of missed diagnosis, sensitivity, specificity and Youden index were 89.3%, 36.4%, 4.0%, 90.6%, 25.0% and 59.6%, respectively, B physician diagnosed Kappa index was 0.465, P=0.496, and there was no statistically significant difference between the detection rate of basal cell carcinoma by A physician and pathological examination(P>0.05). Conclusion Dermoscopic diagnosis of head facial pigmented basal cell carcinoma can achieve examination consistent with pathology; the diagnostic is speedy, convenient and noninvasive, which has important clinical value. Key words: Dermoscopic; Pigmented basal cell carcinoma; Diagnostic methods; Pathological examination
{"title":"The value of skin endoscopy in the diagnosis of pigmented basal cell carcinoma of the head and face","authors":"Xiao‐Yong Shen","doi":"10.3760/CMA.J.ISSN.1673-8799.2017.06.011","DOIUrl":"https://doi.org/10.3760/CMA.J.ISSN.1673-8799.2017.06.011","url":null,"abstract":"Objective \u0000To evaluate and analysis the value of skin endoscopy in the diagnosis of pigmented basal cell carcinoma of the head and face. \u0000 \u0000 \u0000Methods \u0000A retrospective study was performed on 36 cases of patients(male 20 cases, female 16 cases, aged from 34~66 years old)with suspected pigmented basal cell from January to December 2014.The lesions mainly located in the head and neck, all patients received skin lesion endoscopy, and by 2 senior physicians from department of dermatology, according to the pathological characteristics of mirror skin pigmented basal cell carcinoma, independent of disease diagnosis, the pathological lesion diagnosis as the 'gold standard’, compared and studied the consistency of skin biopsy with pathological findings in the diagnosis of head to head facial pigmented basal cell carcinoma, and analyzed the sensitivity and specificity of diagnosis method. \u0000 \u0000 \u0000Results \u0000Among 36 cases of suspected patients, 25 cases of pigmented basal cell carcinoma were confirmed by histopathology; 27 cases of pigmented basal cell carcinoma were confirmed by A physician, the accuracy, misdiagnosis rate, the rate of missed diagnosis, sensitivity, specificity and Youden index were 92.6%, 27.3%, 4.0%, 87.5%, 33.3% and 68.7%, respectively, A physician diagnosed Kappa index was 0.965, P=0.326, and there was no statistically significant difference between the detection rate of basal cell carcinoma by A physician and pathological examination(P>0.05); 28 cases of pigmented basal cell carcinoma were confirmed by B physician, the accuracy, misdiagnosis rate, the rate of missed diagnosis, sensitivity, specificity and Youden index were 89.3%, 36.4%, 4.0%, 90.6%, 25.0% and 59.6%, respectively, B physician diagnosed Kappa index was 0.465, P=0.496, and there was no statistically significant difference between the detection rate of basal cell carcinoma by A physician and pathological examination(P>0.05). \u0000 \u0000 \u0000Conclusion \u0000Dermoscopic diagnosis of head facial pigmented basal cell carcinoma can achieve examination consistent with pathology; the diagnostic is speedy, convenient and noninvasive, which has important clinical value. \u0000 \u0000 \u0000Key words: \u0000Dermoscopic; Pigmented basal cell carcinoma; Diagnostic methods; Pathological examination","PeriodicalId":64135,"journal":{"name":"中国临床实用医学","volume":"8 1","pages":"42-45"},"PeriodicalIF":0.0,"publicationDate":"2017-12-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41796851","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2017-10-25DOI: 10.3760/CMA.J.ISSN.1673-8799.2017.05.007
Xiangxin Zheng, Xiaoqing Guan, Ji Wu, Shu-cheng Gu, Xiaoling Jiang, Xiǎohóng Shí, Mu Yuan, B. Lu, X. Qiu, Xuxu Zhang
Objective To investigate the value of molecular typing in primary tumor and axillary lymph node metastasis of breast cancer. Methods A total of 428 cases of female patients with unilateral breast cancer with axillary lymph node metastasis were selected from January 2011 to January 2016.ER, PR, Her-2 and Ki67 were detected by immunohistochemistry in primary tumor and axillary lymph node metastasis. Results Molecular typing of primary tumor and axillary lymph node metastases was inconsistent in 31 patients (31/428), luminal A of primary tumors in 14 cases, luminal B of primary tumors in 10 cases, while 4 cases of Her-2 over-expression and 3 cases of triple negative breast cancer in axillary lymph node metastases. Conclusion There was an inconsistency in primary tumor and axillary lymph node metastasis of some breast cancer.Immunohistochemistry for primary tumor and axillary lymph node metastasis of breast cancer associated with axillary lymph node metastasis should routinely carried out.Based on molecular typing of primary tumor and axillary lymph node metastasis to develop individualized treatment programs, patients could benefit from it. Key words: Breast cancer; Primary focus; Axillary lymph node metastasis; Molecular typing; Chemotherapy; Hormonal therapy
{"title":"A study of the inconsistency of molecular typing in primary tumor and axillary lymph node metastasis of breast cancer","authors":"Xiangxin Zheng, Xiaoqing Guan, Ji Wu, Shu-cheng Gu, Xiaoling Jiang, Xiǎohóng Shí, Mu Yuan, B. Lu, X. Qiu, Xuxu Zhang","doi":"10.3760/CMA.J.ISSN.1673-8799.2017.05.007","DOIUrl":"https://doi.org/10.3760/CMA.J.ISSN.1673-8799.2017.05.007","url":null,"abstract":"Objective \u0000To investigate the value of molecular typing in primary tumor and axillary lymph node metastasis of breast cancer. \u0000 \u0000 \u0000Methods \u0000A total of 428 cases of female patients with unilateral breast cancer with axillary lymph node metastasis were selected from January 2011 to January 2016.ER, PR, Her-2 and Ki67 were detected by immunohistochemistry in primary tumor and axillary lymph node metastasis. \u0000 \u0000 \u0000Results \u0000Molecular typing of primary tumor and axillary lymph node metastases was inconsistent in 31 patients (31/428), luminal A of primary tumors in 14 cases, luminal B of primary tumors in 10 cases, while 4 cases of Her-2 over-expression and 3 cases of triple negative breast cancer in axillary lymph node metastases. \u0000 \u0000 \u0000Conclusion \u0000There was an inconsistency in primary tumor and axillary lymph node metastasis of some breast cancer.Immunohistochemistry for primary tumor and axillary lymph node metastasis of breast cancer associated with axillary lymph node metastasis should routinely carried out.Based on molecular typing of primary tumor and axillary lymph node metastasis to develop individualized treatment programs, patients could benefit from it. \u0000 \u0000 \u0000Key words: \u0000Breast cancer; Primary focus; Axillary lymph node metastasis; Molecular typing; Chemotherapy; Hormonal therapy","PeriodicalId":64135,"journal":{"name":"中国临床实用医学","volume":"8 1","pages":"26-29"},"PeriodicalIF":0.0,"publicationDate":"2017-10-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"45580669","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2017-10-25DOI: 10.3760/CMA.J.ISSN.1673-8799.2017.05.009
Xian-liang Meng
Objective To investigate the changes of serum uric acid (SUA)and its relationship with short-term prognosis in patients with cerebral infarction due to different neurological deficits. Methods A retrospective study was performed on 112 cases of patients with cerebral infarction due to different neurological deficits who were admitted from February 2014 to December 2016.According to the National Institutes of Health Stroke Scale (NIHSS), patients were divided into the mild-moderate group (n=51)and the moderate-severe group (n=61). The NIHSS score was statistically analyzed after the 1st and 7th day onset of disease, respectively, the SUA level was determined, and the prognosis of the patients was assessed by the improved RANKIN scale (mRS)at the 1st and 3rd month. Results In the moderate-severe group, level of SUAday7 was significantly lower than that of SUAday1, the difference value of SUA in the moderate-severe group was significantly higher than that in the mild-moderate group, and the difference had statistical significance (P<0.05); the prognosis in the mild-moderate group was good at the 1st and 3rd month after onset, while in the moderate-severe group, 31 patients had poor prognosis at the end of the first month, 20 patients had poor prognosis at the end of the third month.The logistic regression analysis showed that ΔSUA and NIHSSday1 were the risk factors of prognosis at the end of the first posterior cerebral infarction (P<0.05), NIHSSday1 was a risk factor for prognosis at the end of 3rd month after cerebral infarction (P<0.05). Conclusion The NIHSS score is the risk factor of prognosis in the first day of cerebral infarction, while the reduction of SUA is related to the short-term prognosis. Key words: Neurological deficit; Cerebral infarction; Uric acid; Short-term prognosis
{"title":"Changes of serum uric acid in patients with cerebral infarction in different neurological deficits and their relationship with short-term prognosis","authors":"Xian-liang Meng","doi":"10.3760/CMA.J.ISSN.1673-8799.2017.05.009","DOIUrl":"https://doi.org/10.3760/CMA.J.ISSN.1673-8799.2017.05.009","url":null,"abstract":"Objective \u0000To investigate the changes of serum uric acid (SUA)and its relationship with short-term prognosis in patients with cerebral infarction due to different neurological deficits. \u0000 \u0000 \u0000Methods \u0000A retrospective study was performed on 112 cases of patients with cerebral infarction due to different neurological deficits who were admitted from February 2014 to December 2016.According to the National Institutes of Health Stroke Scale (NIHSS), patients were divided into the mild-moderate group (n=51)and the moderate-severe group (n=61). The NIHSS score was statistically analyzed after the 1st and 7th day onset of disease, respectively, the SUA level was determined, and the prognosis of the patients was assessed by the improved RANKIN scale (mRS)at the 1st and 3rd month. \u0000 \u0000 \u0000Results \u0000In the moderate-severe group, level of SUAday7 was significantly lower than that of SUAday1, the difference value of SUA in the moderate-severe group was significantly higher than that in the mild-moderate group, and the difference had statistical significance (P<0.05); the prognosis in the mild-moderate group was good at the 1st and 3rd month after onset, while in the moderate-severe group, 31 patients had poor prognosis at the end of the first month, 20 patients had poor prognosis at the end of the third month.The logistic regression analysis showed that ΔSUA and NIHSSday1 were the risk factors of prognosis at the end of the first posterior cerebral infarction (P<0.05), NIHSSday1 was a risk factor for prognosis at the end of 3rd month after cerebral infarction (P<0.05). \u0000 \u0000 \u0000Conclusion \u0000The NIHSS score is the risk factor of prognosis in the first day of cerebral infarction, while the reduction of SUA is related to the short-term prognosis. \u0000 \u0000 \u0000Key words: \u0000Neurological deficit; Cerebral infarction; Uric acid; Short-term prognosis","PeriodicalId":64135,"journal":{"name":"中国临床实用医学","volume":"8 1","pages":"35-39"},"PeriodicalIF":0.0,"publicationDate":"2017-10-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"69975458","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2017-10-25DOI: 10.3760/CMA.J.ISSN.1673-8799.2017.05.005
Hong-guang Zhu, Yu-xi Ge, G. Yan
Objective To investigate the distinct imaging features of different pathological subtypes of non-Hodgkin′s lymphomas(NHL)of the nose and pharynx and to improve its diagnostic accuracy. Methods A retrospective study was performed on the imaging materials(including CT or MRI)of 32 patients who were confirmed as NHL of the nose and pharynx by pathology.The materials were divided into two groups: NK/T cell lymphoma(NKTCL)and B cell lymphoma(BCL). The characteristics of the site, size, morphology, growth pattern, regional structure invasion of these lymphomas were evaluated and compared.The results were analyzed by Chi-quare test. Results A total of 12 cases(37.5%)were NK/T cell type, 10 cases(83.3%)mainly had nasal cavity involvement, 2 cases(16.7%)showed Waldeyer′s ring involvement, which were characterized by nasal soft tissue with mold growth.Among these, 7 cases(58.3%)had superficial ulcerations, 6 cases(50.0%)with regional structure invasion, 2 cases(16.7%)lymph node involvements.Besides, 20 cases(62.5%)were B cell type NHL.Among these, 19 cases(95.0%)had Waldeyer′s ring involvement and 1 case(5.0%)occurred in nasal cavity with pharyngeal lymphatic loop soft tissue incrassation, and 2 cases(16.7%)had regional structure involvement of pharyngeal space and bone.All cases showed cervical lymphadenopathy.Results of the Chi-square test showed that NKTCL had a higher incidence of nasal cavity involvement than B cell type NHL(χ2=20.401, P=0.000)and regional structure invasion (χ2=6.400, P=0.011), as well as superficial ulcerations (χ2=11.378, P=0.001). BCL had a higher incidence of Waldeyer′s ring involvement and creeping growth pattern(χ2=20.519, P=0.000), as well as lymphadenopathy(χ2=23.058, P=0.000)compared to NKTCL. Conclusion Primary NHLs of the nose and pharynx of different pathological subtypes has some characteristics on imaging, which may have supplementary value in the lymphoma diagnosis. Key words: Lymphoma; Pathological subtypes; MR; CT
{"title":"Distinct imaging features of different pathological subtypes of B cell non-Hodgkin′s lymphomas of the nose and pharynx ministry type NK/T cell","authors":"Hong-guang Zhu, Yu-xi Ge, G. Yan","doi":"10.3760/CMA.J.ISSN.1673-8799.2017.05.005","DOIUrl":"https://doi.org/10.3760/CMA.J.ISSN.1673-8799.2017.05.005","url":null,"abstract":"Objective \u0000To investigate the distinct imaging features of different pathological subtypes of non-Hodgkin′s lymphomas(NHL)of the nose and pharynx and to improve its diagnostic accuracy. \u0000 \u0000 \u0000Methods \u0000A retrospective study was performed on the imaging materials(including CT or MRI)of 32 patients who were confirmed as NHL of the nose and pharynx by pathology.The materials were divided into two groups: NK/T cell lymphoma(NKTCL)and B cell lymphoma(BCL). The characteristics of the site, size, morphology, growth pattern, regional structure invasion of these lymphomas were evaluated and compared.The results were analyzed by Chi-quare test. \u0000 \u0000 \u0000Results \u0000A total of 12 cases(37.5%)were NK/T cell type, 10 cases(83.3%)mainly had nasal cavity involvement, 2 cases(16.7%)showed Waldeyer′s ring involvement, which were characterized by nasal soft tissue with mold growth.Among these, 7 cases(58.3%)had superficial ulcerations, 6 cases(50.0%)with regional structure invasion, 2 cases(16.7%)lymph node involvements.Besides, 20 cases(62.5%)were B cell type NHL.Among these, 19 cases(95.0%)had Waldeyer′s ring involvement and 1 case(5.0%)occurred in nasal cavity with pharyngeal lymphatic loop soft tissue incrassation, and 2 cases(16.7%)had regional structure involvement of pharyngeal space and bone.All cases showed cervical lymphadenopathy.Results of the Chi-square test showed that NKTCL had a higher incidence of nasal cavity involvement than B cell type NHL(χ2=20.401, P=0.000)and regional structure invasion (χ2=6.400, P=0.011), as well as superficial ulcerations (χ2=11.378, P=0.001). BCL had a higher incidence of Waldeyer′s ring involvement and creeping growth pattern(χ2=20.519, P=0.000), as well as lymphadenopathy(χ2=23.058, P=0.000)compared to NKTCL. \u0000 \u0000 \u0000Conclusion \u0000Primary NHLs of the nose and pharynx of different pathological subtypes has some characteristics on imaging, which may have supplementary value in the lymphoma diagnosis. \u0000 \u0000 \u0000Key words: \u0000Lymphoma; Pathological subtypes; MR; CT","PeriodicalId":64135,"journal":{"name":"中国临床实用医学","volume":"8 1","pages":"14-19"},"PeriodicalIF":0.0,"publicationDate":"2017-10-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"45211173","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2017-10-25DOI: 10.3760/CMA.J.ISSN.1673-8799.2017.05.002
Xu-yun Sun, Z. Li, Jingqi Chen, M. Xiong
Objective To investigate the clinical value of early microsurgery of hypertensive intracerebral hematomas in the basal ganglia via transsylvian-transinsular and cortical fistula approach. Methods A retrospective study was performed on 122 cases of patients with hypertensive intracerebral hematomas in the basal ganglia who were admitted from January 2013 to December 2016.According to different surgical approaches, the patients were divided into the cortical fistula approach (CFA) group and the transsylvian-transinsular approach (TTA) group.In the CFA group, the ipsilateral left middle temporal gyrus was used as the hematoma cavity; in the TTA group, the ipsilateral lateral fissure and the upper lobe of the insular cortex reached the hematoma cavity.After the operation, the patients were examined by brain CT to determine the clearance rate of the hematoma, and the NICU admission time and the daily living ability score were compared between the two groups. Results The differences of postoperative hematoma clearance rate, NICU admission time and ADL between the two groups were statistically significant (P<0.05). Conclusion Compared with the cortical fistula approach, the transsylvian-transinsular approach has higher hematoma clearance rate, shorter NICU admission time and better prognosis, which is worth of clinical promotion. Key words: Transsylvian-transinsular approach; Cortical fistula approach; Microsurgery; Hypertension; Intracerebral hematoma; Basal ganglia
{"title":"Early microsurgery via transsylvian-transinsular approach in hypertensive intracerebral hematomas in the basal ganglia","authors":"Xu-yun Sun, Z. Li, Jingqi Chen, M. Xiong","doi":"10.3760/CMA.J.ISSN.1673-8799.2017.05.002","DOIUrl":"https://doi.org/10.3760/CMA.J.ISSN.1673-8799.2017.05.002","url":null,"abstract":"Objective \u0000To investigate the clinical value of early microsurgery of hypertensive intracerebral hematomas in the basal ganglia via transsylvian-transinsular and cortical fistula approach. \u0000 \u0000 \u0000Methods \u0000A retrospective study was performed on 122 cases of patients with hypertensive intracerebral hematomas in the basal ganglia who were admitted from January 2013 to December 2016.According to different surgical approaches, the patients were divided into the cortical fistula approach (CFA) group and the transsylvian-transinsular approach (TTA) group.In the CFA group, the ipsilateral left middle temporal gyrus was used as the hematoma cavity; in the TTA group, the ipsilateral lateral fissure and the upper lobe of the insular cortex reached the hematoma cavity.After the operation, the patients were examined by brain CT to determine the clearance rate of the hematoma, and the NICU admission time and the daily living ability score were compared between the two groups. \u0000 \u0000 \u0000Results \u0000The differences of postoperative hematoma clearance rate, NICU admission time and ADL between the two groups were statistically significant (P<0.05). \u0000 \u0000 \u0000Conclusion \u0000Compared with the cortical fistula approach, the transsylvian-transinsular approach has higher hematoma clearance rate, shorter NICU admission time and better prognosis, which is worth of clinical promotion. \u0000 \u0000 \u0000Key words: \u0000Transsylvian-transinsular approach; Cortical fistula approach; Microsurgery; Hypertension; Intracerebral hematoma; Basal ganglia","PeriodicalId":64135,"journal":{"name":"中国临床实用医学","volume":"8 1","pages":"3-5"},"PeriodicalIF":0.0,"publicationDate":"2017-10-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"48153292","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2017-10-25DOI: 10.3760/CMA.J.ISSN.1673-8799.2017.05.008
Min Qiao, Lina Dong
Objective To investigate the usefulness of serum IgG4 in distinguishing autoimmune pancreatitis(AIP)from pancreatic cancer. Methods The related studies about the usefulness of serum IgG4 in distinguishing autoimmune pancreatitis from pancreatic cancer which were published in Medline, EMBASE, Springer link, Wanfang, Weipu and CNKI before June 1, 2017 were searched.Studies were selected according to strict determined inclusion and exclusion criteria.Publication bias was analyzed by Stata 12.0 software.The quality of the literature was evaluated by the quality evaluation tool(QUADAS). Meta-Disc 1.4 statistical software was used for heterogeneity analysis and comprehensive quantitative synthesis, and the pooled sensitivity, specificity, positive likelihood and diagnostic odds ratio were calculated respectively, and summary receiver operating characteristic(SROC)curve was drawn.The subgroup analysis was performed according to the regional, diagnostic criteria and serum IgG4 detection method respectively. Results A total of 16 studies were included, the pooled sensitivity was 0.727(95%CI: 0.691 to 0.761), the pooled specificity was 0.924(95%CI: 0.907 to 0.939), the pooled positive likelihood ratio was 10.103(95%CI: 6.795 to 15.022), the pooled diagnostic odds ratio was 50.644(95%CI: 26.473 to 96.883). Subgroup analysis showed that the region was the leading source of heterogeneity.Deeks revealed no publication bias, and sensitivity analysis revealed that the results of this meta-analysis were stable. Conclusion Serum IgG4 has high efficiency in the identification of AIP and pancreatic cancer, while due to geographical differences, the regional diagnostic efficacy is inconsistent.More high-quality forward-looking articles for diagnosis of AIP are needed to provide basis. Key words: Serum IgG4; Autoimmune pancreatitis; Pancreatic cancer; Meta-analysis
{"title":"Value of serum IgG4 in distinguishing autoimmune pancreatitis from pancreatic cancer: a Meta-analysis","authors":"Min Qiao, Lina Dong","doi":"10.3760/CMA.J.ISSN.1673-8799.2017.05.008","DOIUrl":"https://doi.org/10.3760/CMA.J.ISSN.1673-8799.2017.05.008","url":null,"abstract":"Objective \u0000To investigate the usefulness of serum IgG4 in distinguishing autoimmune pancreatitis(AIP)from pancreatic cancer. \u0000 \u0000 \u0000Methods \u0000The related studies about the usefulness of serum IgG4 in distinguishing autoimmune pancreatitis from pancreatic cancer which were published in Medline, EMBASE, Springer link, Wanfang, Weipu and CNKI before June 1, 2017 were searched.Studies were selected according to strict determined inclusion and exclusion criteria.Publication bias was analyzed by Stata 12.0 software.The quality of the literature was evaluated by the quality evaluation tool(QUADAS). Meta-Disc 1.4 statistical software was used for heterogeneity analysis and comprehensive quantitative synthesis, and the pooled sensitivity, specificity, positive likelihood and diagnostic odds ratio were calculated respectively, and summary receiver operating characteristic(SROC)curve was drawn.The subgroup analysis was performed according to the regional, diagnostic criteria and serum IgG4 detection method respectively. \u0000 \u0000 \u0000Results \u0000A total of 16 studies were included, the pooled sensitivity was 0.727(95%CI: 0.691 to 0.761), the pooled specificity was 0.924(95%CI: 0.907 to 0.939), the pooled positive likelihood ratio was 10.103(95%CI: 6.795 to 15.022), the pooled diagnostic odds ratio was 50.644(95%CI: 26.473 to 96.883). Subgroup analysis showed that the region was the leading source of heterogeneity.Deeks revealed no publication bias, and sensitivity analysis revealed that the results of this meta-analysis were stable. \u0000 \u0000 \u0000Conclusion \u0000Serum IgG4 has high efficiency in the identification of AIP and pancreatic cancer, while due to geographical differences, the regional diagnostic efficacy is inconsistent.More high-quality forward-looking articles for diagnosis of AIP are needed to provide basis. \u0000 \u0000 \u0000Key words: \u0000Serum IgG4; Autoimmune pancreatitis; Pancreatic cancer; Meta-analysis","PeriodicalId":64135,"journal":{"name":"中国临床实用医学","volume":"8 1","pages":"30-34"},"PeriodicalIF":0.0,"publicationDate":"2017-10-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"47714635","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2017-10-25DOI: 10.3760/CMA.J.ISSN.1673-8799.2017.05.023
Bailu Qiao, Y. Dang, M. Wei, Shaoqing Zhang
Objective Through observing tissue metalloproteinase inhibitor-1 (TIMP-1), monocyte chemoattractant protein-1 (MCP-1)expression of the 5/6 nephrectomy rat, and observing the relationship between TIMP-1 and MCP-1 with renal fibrosis, to find the probability of TIMP-1 and MCP-1 as biomarkers in early renal fibrosis. Methods The clean grade male rats were randomly divided into the model group and the control group.The rats in the control group were only stripped the renal capsule, without resection of renal parenchyma, the others in the model group were established to be 5/6 renal failure models.Using enzyme-linked immunosorbent assay (ELISA)to detect the expression level of serum hyaluronic acid, laminin, egg white type Ⅲ collagen, type Ⅳ collagen, and using the fluorescent quantitative PCR to detect the expression level of MCP-1 and TIMP-1 mRNA in kidney tissue of two groups of rats, combined with renal pathological changes and serum creatinine and urea nitrogen levels, assessing the significance of MCP-1, TIMP-1 in renal fibrosis. Results After the modeling, the glomerular score, renal interstitial score, serum creatinine and blood urea nitrogen in the model group were higher than those in the control group, and the difference was statistically significant (P<0.05); after the modeling of 4, 8and12 weeks in the model group, the expression of MCP-1 in renal tissue was gradually elevated, the expression of TIMP-1 was gradually reduced, and the expression level born a strong resemblance with the early renal fibrosis process. Conclusion The expression level of the MCP-1 and TIMP-1 born a strong resemblance with the early renal fibrosis, it can be used as a potential biomarker for early renal fibrosis. Key words: Renal fibrosis; Tissue inhibitor of metalloproteinase-1; Monocyte chemoattractant protein-1; Nephrectomy model
{"title":"The expression of TIMP-1 and MCP-1 in 5/6 nephrectomy rats","authors":"Bailu Qiao, Y. Dang, M. Wei, Shaoqing Zhang","doi":"10.3760/CMA.J.ISSN.1673-8799.2017.05.023","DOIUrl":"https://doi.org/10.3760/CMA.J.ISSN.1673-8799.2017.05.023","url":null,"abstract":"Objective \u0000Through observing tissue metalloproteinase inhibitor-1 (TIMP-1), monocyte chemoattractant protein-1 (MCP-1)expression of the 5/6 nephrectomy rat, and observing the relationship between TIMP-1 and MCP-1 with renal fibrosis, to find the probability of TIMP-1 and MCP-1 as biomarkers in early renal fibrosis. \u0000 \u0000 \u0000Methods \u0000The clean grade male rats were randomly divided into the model group and the control group.The rats in the control group were only stripped the renal capsule, without resection of renal parenchyma, the others in the model group were established to be 5/6 renal failure models.Using enzyme-linked immunosorbent assay (ELISA)to detect the expression level of serum hyaluronic acid, laminin, egg white type Ⅲ collagen, type Ⅳ collagen, and using the fluorescent quantitative PCR to detect the expression level of MCP-1 and TIMP-1 mRNA in kidney tissue of two groups of rats, combined with renal pathological changes and serum creatinine and urea nitrogen levels, assessing the significance of MCP-1, TIMP-1 in renal fibrosis. \u0000 \u0000 \u0000Results \u0000After the modeling, the glomerular score, renal interstitial score, serum creatinine and blood urea nitrogen in the model group were higher than those in the control group, and the difference was statistically significant (P<0.05); after the modeling of 4, 8and12 weeks in the model group, the expression of MCP-1 in renal tissue was gradually elevated, the expression of TIMP-1 was gradually reduced, and the expression level born a strong resemblance with the early renal fibrosis process. \u0000 \u0000 \u0000Conclusion \u0000The expression level of the MCP-1 and TIMP-1 born a strong resemblance with the early renal fibrosis, it can be used as a potential biomarker for early renal fibrosis. \u0000 \u0000 \u0000Key words: \u0000Renal fibrosis; Tissue inhibitor of metalloproteinase-1; Monocyte chemoattractant protein-1; Nephrectomy model","PeriodicalId":64135,"journal":{"name":"中国临床实用医学","volume":"8 1","pages":"77-82"},"PeriodicalIF":0.0,"publicationDate":"2017-10-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"47481148","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2017-08-25DOI: 10.3760/CMA.J.ISSN.1673-8799.2017.04.004
Chuan Deng, Chong Zhao, Siqi Ji, Youfa Fang
Objective To evaluate the value of 3d reconstruction in liver cancer resection. Methods This study involved 36 liver cancer patients.According to three-dimensional reconstruction,detected the orientation relationship between tumor location,delimited the surgical excision line and calculation of liver volume.Sugical operation was the same with the plan assisted with preoperative three-dimensional reconstruction. Results 31 of 36 patients accepted the surgery.7 patients appeared complication.7 patients recurred.Postoperative suvival rate of 1 year was 100%.5 patients who no accepted surgery all died in one year. Conclusion The three-dimensional reconstruction technique can clearly show the internal structure of the liver,that can help doctors to formulate precise operation plan and preoperative evaluation,so as to achieve the accurate removal of liver tumor. Key words: Three-dimensional reconstruction; Liver cancer; Accurate hepatectomy; Malignancy
{"title":"Application of three-dimensional reconstruction in the liver cancer resection","authors":"Chuan Deng, Chong Zhao, Siqi Ji, Youfa Fang","doi":"10.3760/CMA.J.ISSN.1673-8799.2017.04.004","DOIUrl":"https://doi.org/10.3760/CMA.J.ISSN.1673-8799.2017.04.004","url":null,"abstract":"Objective \u0000To evaluate the value of 3d reconstruction in liver cancer resection. \u0000 \u0000 \u0000Methods \u0000This study involved 36 liver cancer patients.According to three-dimensional reconstruction,detected the orientation relationship between tumor location,delimited the surgical excision line and calculation of liver volume.Sugical operation was the same with the plan assisted with preoperative three-dimensional reconstruction. \u0000 \u0000 \u0000Results \u000031 of 36 patients accepted the surgery.7 patients appeared complication.7 patients recurred.Postoperative suvival rate of 1 year was 100%.5 patients who no accepted surgery all died in one year. \u0000 \u0000 \u0000Conclusion \u0000The three-dimensional reconstruction technique can clearly show the internal structure of the liver,that can help doctors to formulate precise operation plan and preoperative evaluation,so as to achieve the accurate removal of liver tumor. \u0000 \u0000 \u0000Key words: \u0000Three-dimensional reconstruction; Liver cancer; Accurate hepatectomy; Malignancy","PeriodicalId":64135,"journal":{"name":"中国临床实用医学","volume":"8 1","pages":"11-14"},"PeriodicalIF":0.0,"publicationDate":"2017-08-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"42913574","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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