A study of the inconsistency of molecular typing in primary tumor and axillary lymph node metastasis of breast cancer

Abstract

Objective To investigate the value of molecular typing in primary tumor and axillary lymph node metastasis of breast cancer. Methods A total of 428 cases of female patients with unilateral breast cancer with axillary lymph node metastasis were selected from January 2011 to January 2016.ER, PR, Her-2 and Ki67 were detected by immunohistochemistry in primary tumor and axillary lymph node metastasis. Results Molecular typing of primary tumor and axillary lymph node metastases was inconsistent in 31 patients (31/428), luminal A of primary tumors in 14 cases, luminal B of primary tumors in 10 cases, while 4 cases of Her-2 over-expression and 3 cases of triple negative breast cancer in axillary lymph node metastases. Conclusion There was an inconsistency in primary tumor and axillary lymph node metastasis of some breast cancer.Immunohistochemistry for primary tumor and axillary lymph node metastasis of breast cancer associated with axillary lymph node metastasis should routinely carried out.Based on molecular typing of primary tumor and axillary lymph node metastasis to develop individualized treatment programs, patients could benefit from it. Key words: Breast cancer; Primary focus; Axillary lymph node metastasis; Molecular typing; Chemotherapy; Hormonal therapy