Efficacy and safety of Yinchenhao Decoction combined with blue light irradiation in the treatment of neonatal pathological jaundice

Abstract

Objective To explore the efficacy and safety of Yinchenhao Decoction combined with blue light irradiation in the treatment of neonatal pathological jaundice. Methods From January 2018 to October 2018, a total of 94 neonates with pathological jaundice admitted to our hospital were divided into the control group and the observation group, with 47 cases in each group.On the basis of conventional treatment, the control group was given blue light irradiation treatment, while the observation group was treated with Yinchenhao Decoction on the basis of the control group.The changes of TBIL, UCB, TBA and HS-CRP levels, β-GD levels, clinical efficacy and incidence of adverse events were compared between the two groups after 7 days of treatment. Results After 7 days of treatment, the TBIL, UCB, TBA and HS-CRP levels in the observation group were (116.4±6.9)μmol/L, (153.6±8.2)μmol/L, (8.3±1.3)μmol/L, (4.9±0.6)mg/L, respectively, which were lower than those in the control group [(153.6±8.2)μmol/L, (249.3±42.3)μmol/L, (25.9±2.9)μmol/L, (18.3±0.5)mg/L] (t=15.851, 20.329, 9.624, 7.508, all P<0.05). The β-GD level reduced more significant in the observation group, which in both two groups were decreased after treatment (all P<0.05). The total effective rate of the observation group was 97.9%(46/47), which was significantly higher than that of the control group[85.1%(40/47)], and the total incidence of adverse reactions in the observation group was 4.3%(2/47), which was significantly lower than that in the control group[29.8%(17/47)], the differences were statistically significant(χ2=11.562, 14.605, all P<0.01). Conclusion Yinchenhao Decoction combined with blue light irradiation is effective in the treatment of neonatal pathological jaundice, possibly by affecting β-GD levels.In addition, it can significantly reduce the incidence of adverse reactions in children, with better efficacy and higher safety.It is worthy of clinical reference and promotion. Key words: Jaundice, neonatal; Drugs, Chinese herbal; Balneology; Color therapy; Bilirubin; Bile acids and salts; C-reactive protein; Aldehyde dehydrogenase; Comparative study