Relationship between the expression of microRNA-16, microRNA-124 and microRNA-195 in peripheral blood of schizophrenic patients and their cognitive and social functions

中国基层医药 Pub Date : 2020-03-15 DOI:10.3760/CMA.J.ISSN.1008-6706.2020.06.019

Qiao Xu, Weihua Zhang, Zhenyuan Luo

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Abstract

Objective To investigate the correlation between the expression of microRNA-16, mircoRNA-124 and mircoRNA-195 in peripheral blood of schizophrenic patients and their cognitive and social functions. Methods From January 2016 to December 2018, 112 schizophrenic patients admitted to the Second People's Hospital of Taizhou were selected as observation group, and 93 healthy examinees from the Second People's Hospital of Taizhou were selected as control group.The expression of mircoRNA-16, mircoRNA 124 and mircoRNA 195 in peripheral blood was detected by real-time quantitative fluorescent PCR.The cognitive function of patients was evaluated by Chinese version of Montreal Cognitive Assessment Scale (MoCA), and the social function of inpatients with mental illness was evaluated by SSPI. Results The expression of mircoRNA-16 (0.03±0.01) and mircoRNA 195(0.08±0.03) in peripheral blood of the observation group was lower than that of the control group[(0.12±0.02) and (0.27±0.06)], while the expression of mircoRNA 124 (14.63±3.24) of the observation group was higher than that of the control group (7.45±1.39), the differences were statistically significant(t=41.763, 19.898, 29.389, all P<0.05). The score of MoCA scale in the observation group[(22.17±3.45)points]was lower than that in the control group[(28.39±1.28)points](t=16.465, P<0.05). The SSPI score of the observation group[(26.58±5.16)points]was lower than that of the control group[(45.37±3.27)points](t=30.405, P<0.05). MicroRNA-16 and microRNA-195 were positively correlated with MoCA scale score and SSPI scale score (r=0.641, 0.724, SSPI scale score: r=0.801, 0.657, all P<0.05), while microRNA-124 was negatively correlated with MoCA scale score and SSPI scale score (r=-0.738, -0.769, all P<0.05). Conclusion The expression of mircoRNA-16 and mircoRNA-195 in peripheral blood of schizophrenic patients decreased, while the expression of mircoRNA-124 increased.The expressions of mircoRNA-16 and mircoRNA-195 were positively correlated with cognitive and social functions, while mircoRNA-124 was negatively correlated with cognitive and social functions. Key words: Schizophrenia; Healthy examinees; Peripheral blood; MicroRNA-16; MicroRNA-124; MicroRNA-195; Cognitive function; Social function; Relevance

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精神分裂症患者外周血微小RNA-16、微小RNA-124和微小RNA-195的表达与认知和社会功能的关系

目的探讨精神分裂症患者外周血微小核糖核酸-16、微小核糖核酸-124和微小核糖核酸-195的表达与认知和社会功能的关系。方法选择2016年1月至2018年12月收治在台州市第二人民医院的112例精神分裂症患者作为观察组，选择台州市第三人民医院的93名健康体检者作为对照组。采用实时荧光定量PCR法检测外周血中mircoRNA-16、mircoRNA124和mircoRNA195的表达，采用中文版《蒙特利尔认知评定量表》（MoCA）评定患者的认知功能，采用SSPI评定精神病住院患者的社会功能。结果观察组外周血中mircoRNA-16（0.03±0.01）和mircoRNA195（0.08±0.03）的表达低于对照组[（0.12±0.02）和（0.27±0.06）]，而mircoRNA124（14.63±3.24）的表达高于对照组（7.45±1.39），差异有统计学意义（t=41.763，19.898，29.389，均P<0.05）。观察组MoCA量表评分[（22.17±3.45）分]低于对照组[（28.39±1.28）分]（t=16.465，P<0.05）microRNA-195与MoCA量表评分和SSPI量表评分呈正相关（r=0.641，0.724，SSPI量图评分：r=0.801，0.657，均P<0.05），而microRNA-124与MoCA评分和SSPI量表评分呈负相关（r=-0.738，-0.769，均<0.05），而mircoRNA-124的表达增加。mircoRNA-16和mircoRNA-195的表达与认知和社交功能呈正相关，而mircoRNA-124与认知和社会功能呈负相关。关键词：精神分裂症；健康的考生；外周血；MicroRNA-16；MicroRNA-124；MicroRNA-195；认知功能；社会功能；相关性

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来源期刊

中国基层医药

CiteScore

0.10

自引率

0.00%

发文量

32251

期刊介绍： Since its inception, the journal "Chinese Primary Medicine" has adhered to the development strategy of "based in China, serving the grassroots, and facing the world" as its publishing concept, reporting a large amount of the latest medical information at home and abroad, prospering the academic field of primary medicine, and is praised by readers as a medical encyclopedia that updates knowledge. It is a core journal in China's medical and health field, and its influence index (CI) ranks Q2 in China's academic journals in 2022. It was included in the American Chemical Abstracts in 2008, the World Health Organization Western Pacific Regional Medical Index (WPRIM) in 2009, and the Japan Science and Technology Agency Database (JST) and Scopus Database in 2018, and was included in the Wanfang Data-China Digital Journal Group and the China Academic Journal Comprehensive Evaluation Database.