Exploring Therapeutic Potential Of Invasomes, Transfersomes, Transethosomes, Oleic Acid Vesicles, And Cubosomes Adopting Topical/Transdermal Route

Q3 Engineering Micro and Nanosystems Pub Date : 2021-04-06 DOI:10.2174/1876402913666210406163452
Shivani Verma, Puneet Utreja
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引用次数: 3

Abstract

Transdermal drug delivery is considered as a better alternative to oral administration of drugs like proteins or peptides that are susceptible to extensive degradation via first pass metabolism. This delivery route also shows high patient compliance due to no use of painful injections. Conventional delivery systems like creams and gel show poor skin permeation and high dosing frequency. The objective of this work was to investigate the role of highly advanced micro and nanocarrier systems like invasomes, transfersomes, transethosomes, oleic acid vesicles, and cubosomes for transdermal drug delivery exploring literature survey. Literature survey for these advanced micro and nanocarrier systems was carried out using search engines like Pubmed and Google scholar. Results of literature investigations revealed that advanced micro and nanocarrier systems discussed earlier have the caliber to enhance skin permeation of various bioactives, show sustain release, and target particular areas of skin better compared to old nanocarriers like liposomes. Present review concludes that advanced micro and nanocarrier systems like invasomes, transfersomes, transethosomes, oleic acid vesicles, and cubosomes are better alternatives for transdermal delivery of therapeutic agents compared to old nanocarriers like liposomes and conventional delivery systems like creams and gels.
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采用局部/经皮途径探索血管内体、转运体、溶酶体、油酸囊泡和立方体的治疗潜力
经皮给药被认为是口服药物(如蛋白质或肽)的更好替代方案,这些药物易通过首过代谢进行广泛降解。由于没有使用疼痛的注射,这种输送途径也显示出高的患者依从性。传统的递送系统,如乳膏和凝胶,显示出较差的皮肤渗透性和较高的给药频率。本工作的目的是研究高度先进的微载体和纳米载体系统,如内酰胺体、转移体、穿醇体、油酸囊泡和立方体在透皮给药中的作用,探索文献调查。使用Pubmed和谷歌学者等搜索引擎对这些先进的微载体和纳米载体系统进行了文献调查。文献调查结果表明,与脂质体等旧的纳米载体相比,前面讨论的先进的微载体和纳米载体系统具有增强各种生物活性物质皮肤渗透、显示持续释放和更好地靶向皮肤特定区域的能力。目前的综述得出结论,与脂质体等旧的纳米载体和乳膏和凝胶等传统递送系统相比,先进的微载体和纳米载体系统,如内酰胺体、转移体、跨醇体、油酸囊泡和立方体,是更好的透皮递送治疗剂的替代品。
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来源期刊
Micro and Nanosystems
Micro and Nanosystems Engineering-Building and Construction
CiteScore
1.60
自引率
0.00%
发文量
50
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